Gene/Proteome Database (LMPD)

LMPD ID
LMP013544
Gene ID
367112
Species
Rattus norvegicus (Rat)
Gene Name
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
Gene Symbol
Hmgcll1
Synonyms
RGD1565090;
Alternate Names
3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic; 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1; 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1;
Chromosome
8
Map Location
8q24
EC Number
4.1.3.4

Proteins

3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic
Refseq ID NP_001263401
Protein GI 451770389
UniProt ID D4A5C3
mRNA ID NM_001276472
Length 343
MGNLPSAAKHCLNYQQLLREHLWSGESVAGALDPAQEASQLSGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIEFINQLSQTGLSVIEVTSFVSSRWVPQMADHAEVMGGIHQYPGVRYPVLVPNLQGLQHAVAAGATEIAVFGAASESFSKKNINCSIEESMGRFEQVISSARHMNIPVRGYVSCALGCPYEGSIMPQKVTEVSKRLYSMGCYEISLGDTVGVGTPGSMKTMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGMGLNTGVDLHKVMEAGDFICKAVNKTTNSKVAQASFKARLE

Gene Information

Entrez Gene ID
367112
Gene Name
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
Gene Symbol
Hmgcll1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 ISS:UniProtKB C cytosol
GO:0005783 ISS:UniProtKB C endoplasmic reticulum
GO:0016020 ISS:UniProtKB C membrane
GO:0048471 ISS:UniProtKB C perinuclear region of cytoplasm
GO:0004419 ISS:UniProtKB F hydroxymethylglutaryl-CoA lyase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0046951 ISS:UniProtKB P ketone body biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR013785 Aldolase-type TIM barrel
IPR000891 Pyruvate carboxyltransferase

UniProt Annotations

Entry Information

Gene Name
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
Protein Entry
HMGC2_RAT
UniProt ID
D4A5C3
Species
Rat

Comments

Comment Type Description
Catalytic Activity (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl- CoA + acetoacetate.
Cofactor Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence= ; Note=Divalent metal cations. ;
Function Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues
Pathway Metabolic intermediate metabolism; (S)-3-hydroxy-3- methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3- methylglutaryl-CoA: step 1/1.
Similarity Belongs to the HMG-CoA lyase family
Subcellular Location Cytoplasm, cytosol . Endoplasmic reticulum membrane ; Peripheral membrane protein .
Tissue Specificity Present at high level in duodenum and small intestine (at protein level)

Identical and Related Proteins

Unique RefSeq proteins for LMP013544 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
451770389 RefSeq NP_001263401 343 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic

Identical Sequences to LMP013544 proteins

Reference Database Accession Length Protein Name
GI:451770389 GenBank EDL77774.1 343 similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 (predicted), isoform CRA_a [Rattus norvegicus]
GI:451770389 SwissProt D4A5C3.1 343 RecName: Full=3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic; AltName: Full=3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1 [Rattus norvegicus]

Related Sequences to LMP013544 proteins

Reference Database Accession Length Protein Name
GI:451770389 GenBank EDL77774.1 343 similar to 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 (predicted), isoform CRA_a [Rattus norvegicus]
GI:451770389 GenBank ERE76274.1 343 putative 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2 [Cricetulus griseus]
GI:451770389 RefSeq XP_007611886.1 343 PREDICTED: 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform X1 [Cricetulus griseus]
GI:451770389 SwissProt D4A5C3.1 343 RecName: Full=3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic; AltName: Full=3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1 [Rattus norvegicus]