Gene/Proteome Database (LMPD)

LMPD ID
LMP013539
Gene ID
366508
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Gene Symbol
Pik3cd
Alternate Names
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; catalytic phosphatidylinositol 3-kinase delta; phosphoinositide-3-kinase, catalytic, delta polypeptide; phosphatidylinositol 3-kinase catalytic delta polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform;
Chromosome
5
Map Location
5q36

Proteins

phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Refseq ID NP_001102448
Protein GI 157822959
UniProt ID D4A5Q1
mRNA ID NM_001108978
Length 944
MPPGVDCPMEFWTKEESQSVAVDFLLPTGVYLNFPVSRNANLSTIKQVLWHRAQYEPFFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLGWVEWLQYSFPLQLEPSARGWRAGLLHVSNRPLLVNVKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVERPEEYALQVNGRHEYLYGSYPLCHFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRVKPPPIPAKKPSSVSLWSLEQPFCIELIEGRKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISICDLPRMARLCFALYAVVEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELMNPAGTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRITEEEMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKASSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDSKMKPLWIMYSSEKAGGAGSVGIIFKNGDDLRQDMLTLQMIQLMDFLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQTLWH

Gene Information

Entrez Gene ID
366508
Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Gene Symbol
Pik3cd
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0005942 IBA:RefGenome C phosphatidylinositol 3-kinase complex
GO:0005886 IBA:RefGenome C plasma membrane
GO:0016303 IBA:RefGenome F 1-phosphatidylinositol-3-kinase activity
GO:0035005 IBA:RefGenome F 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0046934 IBA:RefGenome F phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0042113 IEA:Ensembl P B cell activation
GO:0001782 IEA:Ensembl P B cell homeostasis
GO:0007166 IEA:Ensembl P cell surface receptor signaling pathway
GO:0036092 IBA:GOC P phosphatidylinositol-3-phosphate biosynthetic process
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling

KEGG Pathway Links

KEGG Pathway ID Description
ko04152 AMPK signaling pathway
rno04152 AMPK signaling pathway
ko05221 Acute myeloid leukemia
rno05221 Acute myeloid leukemia
ko04261 Adrenergic signaling in cardiomyocytes
rno04261 Adrenergic signaling in cardiomyocytes
ko04960 Aldosterone-regulated sodium reabsorption
rno04960 Aldosterone-regulated sodium reabsorption
ko05146 Amoebiasis
rno05146 Amoebiasis
ko04210 Apoptosis
rno04210 Apoptosis
ko04662 B cell receptor signaling pathway
rno04662 B cell receptor signaling pathway
ko05100 Bacterial invasion of epithelial cells
rno05100 Bacterial invasion of epithelial cells
ko04973 Carbohydrate digestion and absorption
rno04973 Carbohydrate digestion and absorption
ko05142 Chagas disease (American trypanosomiasis)
rno05142 Chagas disease (American trypanosomiasis)
ko04062 Chemokine signaling pathway
rno04062 Chemokine signaling pathway
rno04725 Cholinergic synapse
ko05220 Chronic myeloid leukemia
rno05220 Chronic myeloid leukemia
ko05210 Colorectal cancer
rno05210 Colorectal cancer
ko05213 Endometrial cancer
rno05213 Endometrial cancer
ko05169 Epstein-Barr virus infection
rno05169 Epstein-Barr virus infection
ko04012 ErbB signaling pathway
rno04012 ErbB signaling pathway
ko04915 Estrogen signaling pathway
rno04915 Estrogen signaling pathway
ko04664 Fc epsilon RI signaling pathway
rno04664 Fc epsilon RI signaling pathway
ko04666 Fc gamma R-mediated phagocytosis
rno04666 Fc gamma R-mediated phagocytosis
ko04510 Focal adhesion
rno04510 Focal adhesion
rno04068 FoxO signaling pathway
ko05214 Glioma
rno05214 Glioma
rno04066 HIF-1 signaling pathway
ko05166 HTLV-I infection
rno05166 HTLV-I infection
rno05161 Hepatitis B
ko05160 Hepatitis C
rno05160 Hepatitis C
ko04750 Inflammatory mediator regulation of TRP channels
rno04750 Inflammatory mediator regulation of TRP channels
ko05164 Influenza A
rno05164 Influenza A
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
ko04910 Insulin signaling pathway
rno04910 Insulin signaling pathway
ko04630 Jak-STAT signaling pathway
rno04630 Jak-STAT signaling pathway
ko04670 Leukocyte transendothelial migration
rno04670 Leukocyte transendothelial migration
ko05162 Measles
rno05162 Measles
ko05218 Melanoma
rno05218 Melanoma
ko04650 Natural killer cell mediated cytotoxicity
rno04650 Natural killer cell mediated cytotoxicity
ko04722 Neurotrophin signaling pathway
rno04722 Neurotrophin signaling pathway
ko04932 Non-alcoholic fatty liver disease (NAFLD)
rno04932 Non-alcoholic fatty liver disease (NAFLD)
ko05223 Non-small cell lung cancer
rno05223 Non-small cell lung cancer
ko04380 Osteoclast differentiation
rno04380 Osteoclast differentiation
ko04921 Oxytocin signaling pathway
rno04921 Oxytocin signaling pathway
ko04151 PI3K-Akt signaling pathway
rno04151 PI3K-Akt signaling pathway
ko05212 Pancreatic cancer
rno05212 Pancreatic cancer
rno05200 Pathways in cancer
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
rno04611 Platelet activation
ko04914 Progesterone-mediated oocyte maturation
rno04914 Progesterone-mediated oocyte maturation
ko04917 Prolactin signaling pathway
rno04917 Prolactin signaling pathway
ko05215 Prostate cancer
rno05215 Prostate cancer
ko05205 Proteoglycans in cancer
rno05205 Proteoglycans in cancer
ko04015 Rap1 signaling pathway
rno04015 Rap1 signaling pathway
rno04014 Ras signaling pathway
ko04810 Regulation of actin cytoskeleton
rno04810 Regulation of actin cytoskeleton
ko05211 Renal cell carcinoma
rno05211 Renal cell carcinoma
ko04550 Signaling pathways regulating pluripotency of stem cells
rno04550 Signaling pathways regulating pluripotency of stem cells
ko05222 Small cell lung cancer
rno05222 Small cell lung cancer
ko04660 T cell receptor signaling pathway
rno04660 T cell receptor signaling pathway
ko04668 TNF signaling pathway
rno04668 TNF signaling pathway
rno04919 Thyroid hormone signaling pathway
ko04620 Toll-like receptor signaling pathway
rno04620 Toll-like receptor signaling pathway
ko05145 Toxoplasmosis
rno05145 Toxoplasmosis
ko04930 Type II diabetes mellitus
rno04930 Type II diabetes mellitus
ko04370 VEGF signaling pathway
rno04370 VEGF signaling pathway
ko05203 Viral carcinogenesis
rno05203 Viral carcinogenesis
ko04024 cAMP signaling pathway
rno04024 cAMP signaling pathway
ko04022 cGMP-PKG signaling pathway
rno04022 cGMP-PKG signaling pathway
ko04150 mTOR signaling pathway
rno04150 mTOR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5953415 Adaptive Immune System
5953413 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
5954570 Constitutive PI3K/AKT Signaling in Cancer
5953536 Cytokine Signaling in Immune system
5953408 DAP12 interactions
5953407 DAP12 signaling
5953253 Disease
5953396 Downstream signal transduction
5953994 Downstream signaling events of B Cell Receptor (BCR)
5953399 Downstream signaling of activated FGFR
5953417 Fc epsilon receptor (FCERI) signaling
5953884 GAB1 signalosome
5953410 Immune System
5953409 Innate Immune System
5954000 Interleukin receptor SHC signaling
5953534 Interleukin-2 signaling
5954001 Interleukin-3, 5 and GM-CSF signaling
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953394 NGF signalling via TRKA from the plasma membrane
5954478 PI Metabolism
5953885 PI-3K cascade
5953996 PI3K events in ERBB2 signaling
5953995 PI3K events in ERBB4 signaling
5953997 PI3K/AKT Signaling in Cancer
5953989 PI3K/AKT activation
5953993 PIP3 activates AKT signaling
5953474 Phospholipid metabolism
5954358 Regulation of signaling by CBL
5953998 Role of LAT2/NTAL/LAB on calcium mobilization
5953381 Signal Transduction
5953403 Signaling by EGFR
5953404 Signaling by EGFR in Cancer
5953406 Signaling by ERBB2
5953540 Signaling by ERBB4
5953400 Signaling by FGFR
5953401 Signaling by FGFR in disease
5953535 Signaling by Interleukins
5953397 Signaling by PDGF
5953541 Signaling by SCF-KIT
5953414 Signaling by the B Cell Receptor (BCR)
5953395 Signalling by NGF
5954499 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain
IPR029071 Ubiquitin-related domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Protein Entry
D4A5Q1_RAT
UniProt ID
D4A5Q1
Species
Rat

Comments

Comment Type Description
Similarity Contains PI3K/PI4K domain
Similarity Contains PIK helical domain

Identical and Related Proteins

Unique RefSeq proteins for LMP013539 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157822959 RefSeq NP_001102448 944 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Identical Sequences to LMP013539 proteins

Reference Database Accession Length Protein Name
GI:157822959 GenBank EDL81170.1 944 phosphatidylinositol 3-kinase catalytic delta polypeptide (predicted) [Rattus norvegicus]

Related Sequences to LMP013539 proteins

Reference Database Accession Length Protein Name
GI:157822959 GenBank AAN05615.1 1043 phosphoinositide 3 kinase P110delta [Mus musculus]
GI:157822959 GenBank EDL14872.1 1043 phosphatidylinositol 3-kinase catalytic delta polypeptide, isoform CRA_a [Mus musculus]
GI:157822959 GenBank EDL81170.1 944 phosphatidylinositol 3-kinase catalytic delta polypeptide (predicted) [Rattus norvegicus]
GI:157822959 SwissProt O35904.2 1043 RecName: Full=Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Short=PI3-kinase subunit delta; Short=PI3K-delta; Short=PI3Kdelta; Short=PtdIns-3-kinase subunit delta; AltName: Full=Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; Short=PtdIns-3-kinase subunit p110-delta; Short=p110delta [Mus musculus]