Gene/Proteome Database (LMPD)

LMPD ID
LMP013524
Gene ID
365345
Species
Rattus norvegicus (Rat)
Gene Name
cytochrome b5 reductase 2
Gene Symbol
Cyb5r2
Synonyms
RGD1308421;
Alternate Names
NADH-cytochrome b5 reductase 2; b5R.2;
Chromosome
1
Map Location
1q33
EC Number
1.6.2.2;

Proteins

NADH-cytochrome b5 reductase 2
Refseq ID NP_001014266
Protein GI 62079219
UniProt ID Q6AY12
mRNA ID NM_001014244
Length 276
MSVKKKDLITLQDPEAKYPLPLIEKEQINHNTRRFRFGLPSPDHVLGLPVGNYVHLLAQINNELVIRAYTPVSSDDDQGFVDLIIKIYFKNVHPKYPEGGKMTQYLENMKIGDTILFRGPTGRLFYNEPGTLLIKTDKTSEPEKKLVHHLGMIAGGTGITPMLQLIRHITKDTSDGTRMSLLFANQTEEDILLRKELEEVATTHQNQFSLWYTLDRPPSGWEYSSGFITADMIKEHLPPPGEATLILVCGPPPLIQEAAHPSLEQLGYTKDMIFTY

Gene Information

Entrez Gene ID
365345
Gene Name
cytochrome b5 reductase 2
Gene Symbol
Cyb5r2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IEA:Ensembl C membrane
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005634 IEA:Ensembl C nucleus
GO:0004128 IEA:UniProtKB-EC F cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0016126 IEA:UniProtKB-KW P sterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00520 Amino sugar and nucleotide sugar metabolism
rno00520 Amino sugar and nucleotide sugar metabolism

Domain Information

InterPro Annotations

Accession Description
IPR017927 Ferredoxin reductase-type FAD-binding domain
IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
IPR001834 NADH:cytochrome b5 reductase (CBR)
IPR001433 Oxidoreductase FAD/NAD(P)-binding
IPR008333 Oxidoreductase, FAD-binding domain
IPR017938 Riboflavin synthase-like beta-barrel

UniProt Annotations

Entry Information

Gene Name
cytochrome b5 reductase 2
Protein Entry
NB5R2_RAT
UniProt ID
Q6AY12
Species
Rat

Comments

Comment Type Description
Catalytic Activity NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ;
Function NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2- [4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1) (By similarity)
Similarity Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family
Similarity Contains 1 FAD-binding FR-type domain

Identical and Related Proteins

Unique RefSeq proteins for LMP013524 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
62079219 RefSeq NP_001014266 276 NADH-cytochrome b5 reductase 2

Identical Sequences to LMP013524 proteins

Reference Database Accession Length Protein Name
GI:62079219 EMBL CBX85083.1 276 unnamed protein product [Rattus norvegicus]
GI:62079219 GenBank AAH79235.1 276 Cytochrome b5 reductase 2 [Rattus norvegicus]
GI:62079219 GenBank EDM17954.1 276 cytochrome b5 reductase 2 [Rattus norvegicus]
GI:62079219 SwissProt Q6AY12.1 276 RecName: Full=NADH-cytochrome b5 reductase 2; Short=b5R.2 [Rattus norvegicus]

Related Sequences to LMP013524 proteins

Reference Database Accession Length Protein Name
GI:62079219 EMBL CBX85083.1 276 unnamed protein product [Rattus norvegicus]
GI:62079219 GenBank AAH79235.1 276 Cytochrome b5 reductase 2 [Rattus norvegicus]
GI:62079219 GenBank EDM17954.1 276 cytochrome b5 reductase 2 [Rattus norvegicus]
GI:62079219 SwissProt Q6AY12.1 276 RecName: Full=NADH-cytochrome b5 reductase 2; Short=b5R.2 [Rattus norvegicus]