Gene/Proteome Database (LMPD)

LMPD ID
LMP013467
Gene ID
362061
Species
Rattus norvegicus (Rat)
Gene Name
crystallin, zeta (quinone reductase)
Gene Symbol
Cryz
Alternate Names
quinone oxidoreductase; zeta-crystallin; NADPH:quinone reductase;
Chromosome
2
Map Location
2q45
EC Number
1.6.5.5

Proteins

quinone oxidoreductase
Refseq ID NP_001012183
Protein GI 58865938
UniProt ID Q6AYT0
mRNA ID NM_001012183
Length 329
MATGQKLMRAIRVFEFGGPEVLKLQSDVVVPAPQSHQVLIKVHACGVNPVETYIRSGTYSRKPALPYTPGSDVAGIIESVGDGVSAFKKGDRVFCFSTVSGGYAEFALSADNTTYPLPETLDFRQGAALGIPYFTACRALFHSARARAGESVLVHGASGGVGLATCQIARAHGLKVLGTAGSEEGKKLVLQNGAHEVFNHKEANYIDKIKTSAGDKGVDVIIEMLANKNLSNDLKLLSCGGRVIVVGCRGSIEINPRDTMAKETSIIGVSLFSSTKEEFQQFAGILQAGIEKGWVKPVIGSEYPLEKAAQAHEDIIHSSGKMGKMILLL

Gene Information

Entrez Gene ID
362061
Gene Name
crystallin, zeta (quinone reductase)
Gene Symbol
Cryz
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:Ensembl C Golgi apparatus
GO:0005829 ISS:UniProtKB C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0070402 ISS:UniProtKB F NADPH binding
GO:0003960 ISS:UniProtKB F NADPH:quinone reductase activity
GO:0003730 ISS:UniProtKB F mRNA 3'-UTR binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0051289 IEA:Ensembl P protein homotetramerization
GO:0042178 ISS:UniProtKB P xenobiotic catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR013154 Alcohol dehydrogenase GroES-like
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR013149 Alcohol dehydrogenase, C-terminal
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain
IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site

UniProt Annotations

Entry Information

Gene Name
crystallin, zeta (quinone reductase)
Protein Entry
QOR_RAT
UniProt ID
Q6AYT0
Species
Rat

Comments

Comment Type Description
Catalytic Activity NADPH + 2 quinone = NADP(+) + 2 semiquinone.
Function Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity)
Similarity Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily
Subcellular Location Cytoplasm .
Subunit Homotetramer

Identical and Related Proteins

Unique RefSeq proteins for LMP013467 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
58865938 RefSeq NP_001012183 329 quinone oxidoreductase

Identical Sequences to LMP013467 proteins

Reference Database Accession Length Protein Name
GI:58865938 GenBank EDL82539.1 329 rCG28670, isoform CRA_a [Rattus norvegicus]
GI:58865938 GenBank EDL82540.1 329 rCG28670, isoform CRA_a [Rattus norvegicus]
GI:58865938 RefSeq XP_006233582.1 329 PREDICTED: quinone oxidoreductase isoform X1 [Rattus norvegicus]
GI:58865938 SwissProt Q6AYT0.1 329 RecName: Full=Quinone oxidoreductase; AltName: Full=NADPH:quinone reductase; AltName: Full=Zeta-crystallin [Rattus norvegicus]

Related Sequences to LMP013467 proteins

Reference Database Accession Length Protein Name
GI:58865938 GenBank AAH78927.1 329 Crystallin, zeta [Rattus norvegicus]
GI:58865938 GenBank EDL82539.1 329 rCG28670, isoform CRA_a [Rattus norvegicus]
GI:58865938 GenBank EDL82540.1 329 rCG28670, isoform CRA_a [Rattus norvegicus]
GI:58865938 RefSeq XP_006233582.1 329 PREDICTED: quinone oxidoreductase isoform X1 [Rattus norvegicus]