Gene/Proteome Database (LMPD)

LMPD ID
LMP013456
Gene ID
361736
Species
Rattus norvegicus (Rat)
Gene Name
protein associated with topoisomerase II homolog 1 (yeast)
Gene Symbol
Patl1
Synonyms
Pat1b; RGD1305514;
Alternate Names
protein PAT1 homolog 1; PAT1-like protein 1; protein PAT1 homolog b;
Chromosome
1
Map Location
1q43

Proteins

protein PAT1 homolog 1
Refseq ID NP_001101990
Protein GI 157818115
UniProt ID B5DF93
mRNA ID NM_001108520
Length 770
MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDDDWQEAHERLAELEEKLPVAADEQTGNGERDEMDLLGDHEENLAERLSKMVIENELEDPAVMRAVQTRPVLQPQPGSLNSSIWDGSEVLRRIRGPLLAQEMPTVSVLEYALPQRPPQGPEDDRDLSERALPRRSTSPIIGSPPVRAVPIGTPPKQMAVPSFNQQILCPKPVHVRPPMPPRYPAPYGERMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPGFRAFFSAPPPATPPPQQHPPGPGPHLQNLRPQAPMFRPDTTHLHPQHRRLLHQRQLQSRNQHRNLNGTGDRGGHRVSHQDHLRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKSSAAEEMQGDGPKKERTKLITPQVARLEHAYKPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALTDERKHKIWSMYDNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMATARNLPFLIKKDAQDEVLPCLLSPFSLLLYHLPSVTVTSLLQQLMNLPQSATAPAPSNSHLTAVLQNKFGLSLLLILLSRGEDLHSSDPTVESTQNNQWTEVMFMATQELLRIPQAALAKPISIPTNLVSLFSRYVDRQKLNLLETKLQLVQGMR

Gene Information

Entrez Gene ID
361736
Gene Name
protein associated with topoisomerase II homolog 1 (yeast)
Gene Symbol
Patl1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030014 IEA:Ensembl C CCR4-NOT complex
GO:0000932 ISS:UniProtKB C cytoplasmic mRNA processing body
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0003723 ISS:UniProtKB F RNA binding
GO:0044822 IEA:Ensembl F poly(A) RNA binding
GO:0034046 IEA:Ensembl F poly(G) binding
GO:0008266 IEA:Ensembl F poly(U) RNA binding
GO:0033962 ISS:UniProtKB P cytoplasmic mRNA processing body assembly
GO:0000290 ISS:UniProtKB P deadenylation-dependent decapping of nuclear-transcribed mRNA

KEGG Pathway Links

KEGG Pathway ID Description
M00395 Decapping complex
ko03018 RNA degradation
rno03018 RNA degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
5954274 Deadenylation-dependent mRNA decay
5953330 Gene Expression
5954273 mRNA decay by 5' to 3' exoribonuclease

Domain Information

InterPro Annotations

Accession Description
IPR019167 Topo_II-assoc_PAT1

UniProt Annotations

Entry Information

Gene Name
protein associated with topoisomerase II homolog 1 (yeast)
Protein Entry
PATL1_RAT
UniProt ID
B5DF93
Species
Rat

Comments

Comment Type Description
Domain The region C, also named Pat-C, is required for RNA- binding and mediates the binding with the Lsm-containing SMN-Sm protein complex and the decapping machinery. It folds into an alpha-alpha superhelix, exposing conserved and basic residues on one side of the domain
Function RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly (By similarity)
Similarity Belongs to the PAT1 family
Subcellular Location Cytoplasm, P-body . Nucleus {ECO:0000250}. Nucleus, PML body . Nucleus speckle . Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing specklesLocalization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus (By similarity)
Subunit Interacts (via region A) with DDX6/RCK. Interacts (via region H and region C) with LSM1 and LSM4. Interacts (via region N) with DCP1A, DCP2, EDC3, EDC4 and XRN1. Interacts with the CCR4- NOT complex. Interacts with the Lsm-containing SMN-Sm protein complex (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP013456 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157818115 RefSeq NP_001101990 770 protein PAT1 homolog 1

Identical Sequences to LMP013456 proteins

Reference Database Accession Length Protein Name
GI:157818115 GenBank EDM12901.1 770 similar to expressed sequence AV312086 (predicted) [Rattus norvegicus]
GI:157818115 GenBank AAI68974.1 770 Protein associated with topoisomerase II homolog 1 (yeast) [Rattus norvegicus]
GI:157818115 SwissProt B5DF93.1 770 RecName: Full=Protein PAT1 homolog 1; AltName: Full=PAT1-like protein 1; AltName: Full=Protein PAT1 homolog b; Short=Pat1b [Rattus norvegicus]

Related Sequences to LMP013456 proteins

Reference Database Accession Length Protein Name
GI:157818115 DBBJ BAE42111.1 770 unnamed protein product [Mus musculus]
GI:157818115 GenBank EDM12901.1 770 similar to expressed sequence AV312086 (predicted) [Rattus norvegicus]
GI:157818115 GenBank AAI68974.1 770 Protein associated with topoisomerase II homolog 1 (yeast) [Rattus norvegicus]
GI:157818115 SwissProt B5DF93.1 770 RecName: Full=Protein PAT1 homolog 1; AltName: Full=PAT1-like protein 1; AltName: Full=Protein PAT1 homolog b; Short=Pat1b [Rattus norvegicus]