Gene/Proteome Database (LMPD)

LMPD ID
LMP013454
Gene ID
361722
Species
Rattus norvegicus (Rat)
Gene Name
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
Gene Symbol
Bscl2
Alternate Names
seipin; bscl2 {ECO:0000250|UniProtKB:Q96G97}; bernardinelli-Seip congenital lipodystrophy type 2 protein homolog;
Chromosome
1
Map Location
1q43

Proteins

seipin
Refseq ID NP_001012171
Protein GI 58865914
UniProt ID Q5FVJ6
mRNA ID NM_001012171
Length 377
MVNDPPVPALLWAQEVGHVLAGRARRLMLQFGVLFCTILLLLWVSVFLYGSFYYSYMPTVSHLSPVHFYYRTDCDSSTASLCSFPVANVSLTKSGRDRVLMYGQPYRVTLELELPESPVNQDLGMFLVTVSCYTRGGRIISTSSRSVMLHYRSQLLQMLDTLVFSSLLLFGFAEQKQLLEVELYSDYRENSYVPTTGAIIEVHSKRVQMYGAYLRIHAHFTGLRYLLYNFPMTCAFVGVASNFTFLSVIALFSYMQWVWGAVWPRHRFSLQVNIRQRDNSGHGAQRRISRHQPGQASTQQSDVTEDGESPEDPSGTEGQLSEEEKPEKQPLNGEGEQEPEASDGSWEDAALLTEASTSALAPETLGSLRQRQTCSSS

Gene Information

Entrez Gene ID
361722
Gene Name
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
Gene Symbol
Bscl2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030176 ISS:UniProtKB C integral component of endoplasmic reticulum membrane
GO:0045444 ISS:UniProtKB P fat cell differentiation
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0034389 ISS:UniProtKB P lipid particle organization
GO:0019915 ISS:UniProtKB P lipid storage
GO:0050995 ISS:UniProtKB P negative regulation of lipid catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR009617 Adipose-regulatory protein, Seipin

UniProt Annotations

Entry Information

Gene Name
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
Protein Entry
BSCL2_RAT
UniProt ID
Q5FVJ6
Species
Rat

Comments

Comment Type Description
Function Is a regulator of lipid catabolism essential for adipocyte differentiation. Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. May also be involved in the central regulation of energy homeostasis (By similarity)
Similarity Belongs to the seipin family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP013454 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
58865914 RefSeq NP_001012171 377 seipin

Identical Sequences to LMP013454 proteins

Reference Database Accession Length Protein Name
GI:58865914 GenBank AAH89942.1 377 Bernardinelli-Seip congenital lipodystrophy 2 homolog (human) [Rattus norvegicus]
GI:58865914 SwissProt Q5FVJ6.1 377 RecName: Full=Seipin; AltName: Full=Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog [Rattus norvegicus]

Related Sequences to LMP013454 proteins

Reference Database Accession Length Protein Name
GI:58865914 GenBank AAH89942.1 377 Bernardinelli-Seip congenital lipodystrophy 2 homolog (human) [Rattus norvegicus]
GI:58865914 GenBank EDM12733.1 437 Bernardinelli-Seip congenital lipodystrophy 2 homolog (human), isoform CRA_a [Rattus norvegicus]
GI:58865914 GenBank EDM12735.1 437 Bernardinelli-Seip congenital lipodystrophy 2 homolog (human), isoform CRA_a [Rattus norvegicus]
GI:58865914 SwissProt Q5FVJ6.1 377 RecName: Full=Seipin; AltName: Full=Bernardinelli-Seip congenital lipodystrophy type 2 protein homolog [Rattus norvegicus]