Gene/Proteome Database (LMPD)

LMPD ID
LMP013446
Gene ID
361637
Species
Rattus norvegicus (Rat)
Gene Name
acyl-CoA synthetase medium-chain family member 5
Gene Symbol
Acsm5
Synonyms
Cc1-38; Aa2-174; RGD1309578;
Alternate Names
acyl-coenzyme A synthetase ACSM5, mitochondrial;
Chromosome
1
Map Location
1q35
EC Number
6.2.1.2

Proteins

acyl-coenzyme A synthetase ACSM5, mitochondrial precursor
Refseq ID NP_001014184
Protein GI 88196780
UniProt ID Q6AYT9
mRNA ID NM_001014162
Length 578
MRLWLRGLVYQARRSSWGVFRIHTQPPPPPIPEVVATWEAISLGKRPVPEYFNFAHDVLDVWSQLEKTGHRPPNPAFWWVNGSGTEVKWTFEELGKQSRKAANILEGACGLKPGDRLMLVLPRLPEWWLTIVACMRTGVVMIPGISQLTQKDLKYRLQAARVKSIITSDALAPHVDAISADCPSLQSRLLVSDTSRPGWINFRELLRVASPEHNCLRTRSGDSMAIYFTSGTTGTPKMVEHSQCSYGLGFVASGRRLMALTESDIFWNTTDTGWVKAAWTLFSAWANGACVFVHELPQVDAQTILNTLCRFPITTICCVPTLFRLLVQEDLTRYKFQCLRHCLAGGEALNSDVRDKWKNQTGLEIHEGYGQSETVLICGNFRGSTIKSGSMGKASPPYDVQIVDEEGNVLPPGKEGNIAIRIKPTRPFCLFNCYLDNPEKTAASEQGDFYITGDRAHMDEDGYFWFVGRNDDVINSSSYRIGPVEVESALAEHPAVLESAVVSSPDPIRGEVVKAFIVLSPAYVSHDPEALTRELQEHVKTVTAPYKYPRKVAFISELPKTVSGKILRSKLRNQEWGR
transit_peptide: 1..22 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q6AYT9.1) calculated_mol_wt: 2751 peptide sequence: MRLWLRGLVYQARRSSWGVFRI mat_peptide: 23..578 product: Acyl-coenzyme A synthetase ACSM5, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q6AYT9.1) calculated_mol_wt: 61890 peptide sequence: HTQPPPPPIPEVVATWEAISLGKRPVPEYFNFAHDVLDVWSQLEKTGHRPPNPAFWWVNGSGTEVKWTFEELGKQSRKAANILEGACGLKPGDRLMLVLPRLPEWWLTIVACMRTGVVMIPGISQLTQKDLKYRLQAARVKSIITSDALAPHVDAISADCPSLQSRLLVSDTSRPGWINFRELLRVASPEHNCLRTRSGDSMAIYFTSGTTGTPKMVEHSQCSYGLGFVASGRRLMALTESDIFWNTTDTGWVKAAWTLFSAWANGACVFVHELPQVDAQTILNTLCRFPITTICCVPTLFRLLVQEDLTRYKFQCLRHCLAGGEALNSDVRDKWKNQTGLEIHEGYGQSETVLICGNFRGSTIKSGSMGKASPPYDVQIVDEEGNVLPPGKEGNIAIRIKPTRPFCLFNCYLDNPEKTAASEQGDFYITGDRAHMDEDGYFWFVGRNDDVINSSSYRIGPVEVESALAEHPAVLESAVVSSPDPIRGEVVKAFIVLSPAYVSHDPEALTRELQEHVKTVTAPYKYPRKVAFISELPKTVSGKILRSKLRNQEWGR

Gene Information

Entrez Gene ID
361637
Gene Name
acyl-CoA synthetase medium-chain family member 5
Gene Symbol
Acsm5
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0005525 IEA:UniProtKB-KW F GTP binding
GO:0047760 IEA:UniProtKB-EC F butyrate-CoA ligase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00650 Butanoate metabolism
rno00650 Butanoate metabolism
rno01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR025110 AMP-binding enzyme C-terminal domain
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase medium-chain family member 5
Protein Entry
ACSM5_RAT
UniProt ID
Q6AYT9
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ;
Function Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity)
Similarity Belongs to the ATP-dependent AMP-binding enzyme family
Subcellular Location Mitochondrion matrix .

Identical and Related Proteins

Unique RefSeq proteins for LMP013446 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
88196780 RefSeq NP_001014184 578 acyl-coenzyme A synthetase ACSM5, mitochondrial precursor

Identical Sequences to LMP013446 proteins

Reference Database Accession Length Protein Name
GI:88196780 GenBank AAH78915.1 578 Acyl-CoA synthetase medium-chain family member 5 [Rattus norvegicus]
GI:88196780 RefSeq XP_006230185.1 578 PREDICTED: acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X1 [Rattus norvegicus]
GI:88196780 RefSeq XP_006230188.1 578 PREDICTED: acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X1 [Rattus norvegicus]
GI:88196780 SwissProt Q6AYT9.1 578 RecName: Full=Acyl-coenzyme A synthetase ACSM5, mitochondrial; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013446 proteins

Reference Database Accession Length Protein Name
GI:88196780 GenBank AAH78915.1 578 Acyl-CoA synthetase medium-chain family member 5 [Rattus norvegicus]
GI:88196780 RefSeq XP_006230185.1 578 PREDICTED: acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X1 [Rattus norvegicus]
GI:88196780 RefSeq XP_006230188.1 578 PREDICTED: acyl-coenzyme A synthetase ACSM5, mitochondrial isoform X1 [Rattus norvegicus]
GI:88196780 SwissProt Q6AYT9.1 578 RecName: Full=Acyl-coenzyme A synthetase ACSM5, mitochondrial; Flags: Precursor [Rattus norvegicus]