Gene/Proteome Database (LMPD)

LMPD ID
LMP013443
Gene ID
361527
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase D family, member 3
Gene Symbol
Pld3
Alternate Names
phospholipase D3; PLD 3; choline phosphatase 3; phosphatidylcholine-hydrolyzing phospholipase D3;
Chromosome
1
Map Location
1q21
EC Number
3.1.4.4

Proteins

phospholipase D3
Refseq ID NP_001012167
Protein GI 58865906
UniProt ID Q5FVH2
mRNA ID NM_001012167
Length 488
MKPKLMYQELKVPVEEPAGELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQHPAPCYDPCEAVLVESIPEGLEFPNATTSNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEPSAQQGEEVLQQLQALAPRGVKVRIAVSKPNGPLADLQSLLQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRPFDTRYNQETPMEICLNGTPALAYLASAPPPLCPGGRTPDLKALLSVVDNARSFIYIAVMNYLPTMEFSHPRRFWPAIDDGLRRAAYERGVKVRLLISCWGHSEPSMRSFLLSLAALRDNHTHSDIQVKLFVVPADEAQARIPYARVNHNKYMVTERTTYIGTSNWSGSYFTETAGTSLLVTQNGHGGLRSQLEAVFLRDWESPYSHNLDTSADSVGNACRLL

Gene Information

Entrez Gene ID
361527
Gene Name
phospholipase D family, member 3
Gene Symbol
Pld3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0070290 IEA:UniProtKB-EC F N-acylphosphatidylethanolamine-specific phospholipase D activity
GO:0004630 IEA:UniProtKB-EC F phospholipase D activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00565 Ether lipid metabolism
rno00565 Ether lipid metabolism
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5954473 Synthesis of PG

Domain Information

InterPro Annotations

Accession Description
IPR001736 Phospholipase D/Transphosphatidylase

UniProt Annotations

Entry Information

Gene Name
phospholipase D family, member 3
Protein Entry
PLD3_RAT
UniProt ID
Q5FVH2
Species
Rat

Comments

Comment Type Description
Catalytic Activity A phosphatidylcholine + H(2)O = choline + a phosphatidate.
Function Probably involved in APP processing
Ptm Glycosylated
Similarity Belongs to the phospholipase D family
Similarity Contains 2 PLD phosphodiesterase domains
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein .
Subunit Interacts with APP

Identical and Related Proteins

Unique RefSeq proteins for LMP013443 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
58865906 RefSeq NP_001012167 488 phospholipase D3

Identical Sequences to LMP013443 proteins

Reference Database Accession Length Protein Name
GI:58865906 RefSeq XP_006228641.1 488 PREDICTED: phospholipase D3 isoform X1 [Rattus norvegicus]
GI:58865906 RefSeq XP_006228642.1 488 PREDICTED: phospholipase D3 isoform X1 [Rattus norvegicus]
GI:58865906 RefSeq XP_006228643.1 488 PREDICTED: phospholipase D3 isoform X1 [Rattus norvegicus]
GI:58865906 RefSeq XP_008757387.1 488 PREDICTED: phospholipase D3 isoform X1 [Rattus norvegicus]

Related Sequences to LMP013443 proteins

Reference Database Accession Length Protein Name
GI:58865906 RefSeq XP_006228640.1 488 PREDICTED: phospholipase D3 isoform X1 [Rattus norvegicus]
GI:58865906 RefSeq XP_006228641.1 488 PREDICTED: phospholipase D3 isoform X1 [Rattus norvegicus]
GI:58865906 RefSeq XP_006228642.1 488 PREDICTED: phospholipase D3 isoform X1 [Rattus norvegicus]
GI:58865906 RefSeq XP_006228643.1 488 PREDICTED: phospholipase D3 isoform X1 [Rattus norvegicus]