Gene/Proteome Database (LMPD)

LMPD ID
LMP013412
Gene ID
353252
Species
Rattus norvegicus (Rat)
Gene Name
retinol dehydrogenase 10 (all-trans)
Gene Symbol
Rdh10
Alternate Names
retinol dehydrogenase 10;
Chromosome
5
Map Location
5q11
EC Number
1.1.1.300;
Summary
human homolog oxidizes all-trans retinol to all-trans retinal using NADP as its prefered cofactor; involved in the photic visual cycle [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Rdh10

Proteins

retinol dehydrogenase 10
Refseq ID NP_852143
Protein GI 31324556
UniProt ID Q80ZF7
mRNA ID NM_181478
Length 341
MNIVVEFFLVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPPCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI

Gene Information

Entrez Gene ID
353252
Gene Name
retinol dehydrogenase 10 (all-trans)
Gene Symbol
Rdh10
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0044297 IDA:RGD C cell body
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0052650 IDA:RGD F NADP-retinol dehydrogenase activity
GO:0004745 IMP:RGD F retinol dehydrogenase activity
GO:0060449 IEA:Ensembl P bud elongation involved in lung branching
GO:0043583 IEA:Ensembl P ear development
GO:0031076 IEA:Ensembl P embryonic camera-type eye development
GO:0035115 IEA:Ensembl P embryonic forelimb morphogenesis
GO:0048703 IEA:Ensembl P embryonic viscerocranium morphogenesis
GO:0008406 IEA:Ensembl P gonad development
GO:0001701 IEA:Ensembl P in utero embryonic development
GO:0001656 IEA:Ensembl P metanephros development
GO:0014032 IEA:Ensembl P neural crest cell development
GO:0043584 IEA:Ensembl P nose development
GO:0060431 IEA:Ensembl P primary lung bud formation
GO:0042574 IDA:RGD P retinal metabolic process
GO:0002138 IEA:Ensembl P retinoic acid biosynthetic process
GO:0007601 IEA:Ensembl P visual perception

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00830 Retinol metabolism
rno00830 Retinol metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5953253 Disease
5953382 Diseases associated with visual transduction
5953381 Signal Transduction
5953384 The canonical retinoid cycle in rods (twilight vision)
5953380 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
retinol dehydrogenase 10 (all-trans)
Protein Entry
RDH10_RAT
UniProt ID
Q80ZF7
Species
Rat

Comments

Comment Type Description
Catalytic Activity All-trans-retinol + NADP(+) = all-trans- retinal + NADPH.
Function Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal
Pathway Cofactor metabolism; retinol metabolism.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular Location Microsome membrane ; Single- pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein .
Tissue Specificity Detected in retina, entire eyecups and in liver (at protein level)

Identical and Related Proteins

Unique RefSeq proteins for LMP013412 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31324556 RefSeq NP_852143 341 retinol dehydrogenase 10

Identical Sequences to LMP013412 proteins

Reference Database Accession Length Protein Name
GI:31324556 GenBank AAO31688.1 341 retinol dehydrogenase 10 [Rattus norvegicus]
GI:31324556 GenBank EDM11512.1 341 retinol dehydrogenase 10 (all-trans), isoform CRA_b [Rattus norvegicus]
GI:31324556 SwissProt Q80ZF7.1 341 RecName: Full=Retinol dehydrogenase 10 [Rattus norvegicus]

Related Sequences to LMP013412 proteins

Reference Database Accession Length Protein Name
GI:31324556 GenBank AAO31688.1 341 retinol dehydrogenase 10 [Rattus norvegicus]
GI:31324556 GenBank EDM11512.1 341 retinol dehydrogenase 10 (all-trans), isoform CRA_b [Rattus norvegicus]
GI:31324556 RefSeq XP_006974775.1 341 PREDICTED: retinol dehydrogenase 10 [Peromyscus maniculatus bairdii]
GI:31324556 SwissProt Q80ZF7.1 341 RecName: Full=Retinol dehydrogenase 10 [Rattus norvegicus]