Gene/Proteome Database (LMPD)

LMPD ID
LMP013408
Gene ID
317576
Species
Rattus norvegicus (Rat)
Gene Name
oculocerebrorenal syndrome of Lowe
Gene Symbol
Ocrl
Alternate Names
inositol polyphosphate 5-phosphatase OCRL-1;
Chromosome
X
Map Location
Xq35
Summary
mutation in human OCRL causes Lowe syndrome, also known as oculocerebrorenal syndrome; mouse homolog RIKEN cDNA 9530014D17 possesses an inositol polyphosphate phosphatase domain [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ocrl

Proteins

inositol polyphosphate 5-phosphatase OCRL-1
Refseq ID NP_001101726
Protein GI 294845709
UniProt ID R9PXS2
mRNA ID NM_001108256
Length 899
MEPRLPIGAQPLAMVAGLEMKGPLREPCVLTLARRNGQYELIIQLHGKEQHVQDIIPINSHFRCVQEAEETLLIDIASNSGCKIRVQGDWTRERHFEIPDEERCLKFLSEVLAAQEAQSQLLVPEQKDSSNWYQKLDTKDKPAYSGLLGFEDNFSSMNLDKKMNTQNPPTGIHREPPPPPSSNRMLPREKEALNKEQPKVTNTMRKLFAPNSQSGQREGLIKHILAKREKEYVNIQSFRFFVGTWNVNGQSPDSSLEPWLNCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWAMAVERGLPSKAKYKKVQLVRLVGMMLLVFAKKDQCQYIRDIATETVGTGIMGKMGNKGGVAMRFVFHNTTFCIVNSHLAAHVEEFERRNQDYKDICARMSFSVPNQTLPQVNIMKHDVVIWLGDLNYRLCMPDANEVKSLINKNELQKLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWRGINVNQLHYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDIVRIMDRMENDFLPSLDLSRREFMFENVKFRQLQKEKFQISNNGQVPCHFSFIPKLNDTQYCKPWLRAEPFEGYLEPNETIDISLDVYVSKDSVTILNSGEDKIEDILVLHLDRGKDYFLTISGNYLPSCFGTSLEALCRMKRPIREVPVTKLIDLEEDSFLEKEKSLLQMVPLDEGTSERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSNHSVAEALLIFLEALPEPVICYELYQRCLDSAHDPRICKQVISQLPRCHRNVFRYLMAFLRELLKFSDYNNVSTNMIATLFTSLLLRPPPNLMARQTPSDRQRAIQFLLVFLLGSEED

Gene Information

Entrez Gene ID
317576
Gene Name
oculocerebrorenal syndrome of Lowe
Gene Symbol
Ocrl
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030136 IEA:Ensembl C clathrin-coated vesicle
GO:0005769 IEA:Ensembl C early endosome
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005634 IEA:Ensembl C nucleus
GO:0001750 IEA:Ensembl C photoreceptor outer segment
GO:0005886 IEA:Ensembl C plasma membrane
GO:0005802 IEA:Ensembl C trans-Golgi network
GO:0030675 IEA:Ensembl F Rac GTPase activator activity
GO:0004439 IEA:Ensembl F phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0042384 IEA:Ensembl P cilium assembly
GO:0001701 IEA:Ensembl P in utero embryonic development
GO:0046856 IEA:Ensembl P phosphatidylinositol dephosphorylation
GO:0032314 IEA:Ensembl P regulation of Rac GTPase activity
GO:0007165 IEA:InterPro P signal transduction

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5954103 Clathrin derived vesicle budding
5954251 Golgi Associated Vesicle Biogenesis
5954515 Inositol phosphate metabolism
5953916 Membrane Trafficking
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954478 PI Metabolism
5953474 Phospholipid metabolism
5953961 Rho GTPase cycle
5953381 Signal Transduction
5953962 Signaling by Rho GTPases
5954516 Synthesis of IP2, IP, and Ins in the cytosol
5954514 Synthesis of IP3 and IP4 in the cytosol
5954502 Synthesis of PIPs at the Golgi membrane
5954104 trans-Golgi Network Vesicle Budding

Domain Information

InterPro Annotations

Accession Description
IPR005135 Endonuclease/exonuclease/phosphatase
IPR000300 Inositol polyphosphate-related phosphatase
IPR008936 Rho GTPase activation protein
IPR000198 Rho GTPase-activating protein domain

UniProt Annotations

Entry Information

Gene Name
oculocerebrorenal syndrome of Lowe
Protein Entry
R9PXS2_RAT
UniProt ID
R9PXS2
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP013408 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
294845709 RefSeq NP_001101726 899 inositol polyphosphate 5-phosphatase OCRL-1

Identical Sequences to LMP013408 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP013408 proteins

Reference Database Accession Length Protein Name
GI:294845709 DBBJ BAE20614.1 900 unnamed protein product [Mus musculus]
GI:294845709 RefSeq XP_006257590.1 886 PREDICTED: inositol polyphosphate 5-phosphatase OCRL-1 isoform X1 [Rattus norvegicus]
GI:294845709 RefSeq XP_006257591.1 878 PREDICTED: inositol polyphosphate 5-phosphatase OCRL-1 isoform X2 [Rattus norvegicus]
GI:294845709 SwissProt D3ZGS3.1 902 RecName: Full=Inositol polyphosphate 5-phosphatase OCRL-1 [Rattus norvegicus]