Gene/Proteome Database (LMPD)

LMPD ID
LMP013376
Gene ID
314438
Species
Rattus norvegicus (Rat)
Gene Name
delta(4)-desaturase, sphingolipid 2
Gene Symbol
Degs2
Synonyms
RGD1305023;
Alternate Names
sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; degs2 {ECO:0000312|EMBL:AAH98701.1}; sphingolipid C4-hydroxylase/delta 4-desaturase;
Chromosome
6
Map Location
6q32
EC Number
1.-.-.-

Proteins

sphingolipid delta(4)-desaturase/C4-hydroxylase DES2
Refseq ID NP_001017457
Protein GI 62945270
UniProt ID Q564G3
mRNA ID NM_001017457
Length 323
MGNSAARSDFEWVYSDQPHTQRRKEMLAKYPSIKALMRPDPNIKWTVLGMVLVQVLACWLVRGLSWRWLLFWAYAFGGCINHSLTLAIHDISHNTAFGTRCASRNRWFAVFANLPIGLPYATSFKKYHVDHHRYLGGDGLDVDIPTDFEGWFFCTPARKLLWLVLQPFFYSLRPLYVNPKAVTRMEILNALVQLAFNVTIFALWGIKAIVYLLASSLLGLGLHPISGHFVAEHYMFLKGHETYSYYGPLNWITFNVGYHVEHHDFPSIPGCYLPLVRMIAPEYYDHLPQHHSWVKVLWDFVFEDSLGPYSRVKRKCKLAKDQL

Gene Information

Entrez Gene ID
314438
Gene Name
delta(4)-desaturase, sphingolipid 2
Gene Symbol
Degs2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0042284 IEA:Ensembl F sphingolipid delta-4 desaturase activity
GO:0000170 IEA:Ensembl F sphingosine hydroxylase activity
GO:0046513 IEA:Ensembl P ceramide biosynthetic process
GO:0006667 IEA:Ensembl P sphinganine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
M00094 Ceramide biosynthesis
rno01100 Metabolic pathways
ko00600 Sphingolipid metabolism
rno00600 Sphingolipid metabolism
M00099 Sphingosine biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954266 Sphingolipid de novo biosynthesis
5954267 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR005804 Fatty acid desaturase, type 1
IPR011388 Sphingolipid delta4-desaturase
IPR013866 Sphingolipid delta4-desaturase, N-terminal

UniProt Annotations

Entry Information

Gene Name
delta(4)-desaturase, sphingolipid 2
Protein Entry
DEGS2_RAT
UniProt ID
Q564G3
Species
Rat

Comments

Comment Type Description
Function Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase
Pathway Membrane lipid metabolism; sphingolipid biosynthesis.
Similarity Belongs to the fatty acid desaturase family. DEGS subfamily
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP013376 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
62945270 RefSeq NP_001017457 323 sphingolipid delta(4)-desaturase/C4-hydroxylase DES2

Identical Sequences to LMP013376 proteins

Reference Database Accession Length Protein Name
GI:62945270 EMBL CAI79417.1 323 rat sphingolipid desaturase [Rattus norvegicus]
GI:62945270 GenBank AAH98701.1 323 Degenerative spermatocyte homolog 2, lipid desaturase (Drosophila) [Rattus norvegicus]
GI:62945270 SwissProt Q564G3.1 323 RecName: Full=Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; AltName: Full=Degenerative spermatocyte homolog 2 [Rattus norvegicus]

Related Sequences to LMP013376 proteins

Reference Database Accession Length Protein Name
GI:62945270 EMBL CAI79417.1 323 rat sphingolipid desaturase [Rattus norvegicus]
GI:62945270 GenBank AAH98701.1 323 Degenerative spermatocyte homolog 2, lipid desaturase (Drosophila) [Rattus norvegicus]
GI:62945270 GenBank EDL97561.1 342 degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase [Rattus norvegicus]
GI:62945270 SwissProt Q564G3.1 323 RecName: Full=Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2; AltName: Full=Degenerative spermatocyte homolog 2 [Rattus norvegicus]