Gene/Proteome Database (LMPD)

LMPD ID
LMP013367
Gene ID
313929
Species
Rattus norvegicus (Rat)
Gene Name
nuclear receptor coactivator 1
Gene Symbol
Ncoa1
Synonyms
SRC-1;
Alternate Names
nuclear receptor coactivator 1; steroid receptor coactivator 1;
Chromosome
6
Map Location
6q14

Proteins

nuclear receptor coactivator 1
Refseq ID NP_001101482
Protein GI 157819661
UniProt ID D4A3Q3
mRNA ID NM_001108012
Length 1417
MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLGTENQEACQRYEVMQCFTVSQPKSIQEDGEGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRINPSVNPGISPAHGVTRSSTLPPSNNNMVSARANRQQSTDLNSGSSHSNSSSSQGSFGCSPGNQIVASVALSQGQAGSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQANSGLATRARMSNNSFPPNIPTLSSPVGITSGACSNNNRSYSNIPVTSLQGMNEGPNNSVGFSAGSPVLRQMSSQNSPSRLSMQPAKAESKDNKEIASILNEMIQSDNSANEGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSSSASSNPSGGTCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPEKKDSASASTAMSVSGQAQGSASIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPAPVTKPAPEEVKLESQSQFSADLDQFDQLLPTLEKAAQLPGLCETDRMDGAVPGVNIKSEILPASLQPTPARSAPRLNRLPELELEAIDNQFGQPGAGDQIPWANNTVTAINQSKPEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFPPQQATPPLMMEDRPTLYPQPYSSPSPTAGLSGPFQGMVRQKPSLGTMPVQVTPPRGTFSPNMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLMHQNRQAILNQFAANAPVGMNMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQIIQQQRAMLMRHQSFGNNIPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLATRSSMVNRGMAGNMGGQFGTGISPQMQQNVFQYPGSGLVPQAEANFAPSLSPGSSMVPMPIPPQSSLLQQTPPTSGYQSPDMKAWQQGTMGNNNVFSQAVQSQPAPAQPGVYNNMSITVSMAGGNANVQNMNPMMGQMQMSSLQMPGMNTVCSEQMNDPALRHTGLYCNQLSSTDLLKTEADGNQDKKTEEFFSVQVQQLQVFADVQCTVNLKGASKPTLVLAVLLQEKAIRTNADEEHGLKTSRKKPFPQVLPSASHRPWYKQLHKNSIYSETTGL

Gene Information

Entrez Gene ID
313929
Gene Name
nuclear receptor coactivator 1
Gene Symbol
Ncoa1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:RGD C cytoplasm
GO:0043005 IDA:RGD C neuron projection
GO:0000790 IEA:Ensembl C nuclear chromatin
GO:0005634 IDA:RGD C nucleus
GO:0001012 IDA:RGD F RNA polymerase II regulatory region DNA binding
GO:0003682 IEA:Ensembl F chromatin binding
GO:0030331 IPI:RGD F estrogen receptor binding
GO:0004402 IEA:InterPro F histone acetyltransferase activity
GO:0016922 IPI:RGD F ligand-dependent nuclear receptor binding
GO:0030374 IEA:Ensembl F ligand-dependent nuclear receptor transcription coactivator activity
GO:0033142 IPI:RGD F progesterone receptor binding
GO:0032403 IPI:RGD F protein complex binding
GO:0042974 IPI:RGD F retinoic acid receptor binding
GO:0046965 IPI:RGD F retinoid X receptor binding
GO:0004871 IEA:InterPro F signal transducer activity
GO:0008134 IPI:RGD F transcription factor binding
GO:0032870 IMP:RGD P cellular response to hormone stimulus
GO:0021549 IEP:RGD P cerebellum development
GO:0021987 IEP:RGD P cerebral cortex development
GO:0021766 IEP:RGD P hippocampus development
GO:0043967 IEA:Ensembl P histone H4 acetylation
GO:0021854 IEP:RGD P hypothalamus development
GO:0060713 IEA:Ensembl P labyrinthine layer morphogenesis
GO:0007595 IEP:RGD P lactation
GO:0008584 IEP:RGD P male gonad development
GO:0060179 IMP:RGD P male mating behavior
GO:0042698 IEP:RGD P ovulation cycle
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process
GO:0045925 IMP:RGD P positive regulation of female receptivity
GO:0045666 IEA:Ensembl P positive regulation of neuron differentiation
GO:0045944 IMP:RGD P positive regulation of transcription from RNA polymerase II promoter
GO:0000435 IEA:Ensembl P positive regulation of transcription from RNA polymerase II promoter by galactose
GO:2001038 IEA:Ensembl P regulation of cellular response to drug
GO:0032355 IMP:RGD P response to estradiol
GO:0009725 IEP:RGD P response to hormone
GO:0032570 IMP:RGD P response to progesterone
GO:0032526 IMP:RGD P response to retinoic acid
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
rno04919 Thyroid hormone signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954496 Activation of gene expression by SREBF (SREBP)
5954332 BMAL1:CLOCK,NPAS2 activates circadian gene expression
5953720 Bile acid and bile salt metabolism
5953258 Biological oxidations
5954223 Circadian Clock
5953485 Cytochrome P450 - arranged by substrate type
5953533 Developmental Biology
5953932 Endogenous sterols
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953330 Gene Expression
5953833 Generic Transcription Pathway
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953600 Mitochondrial biogenesis
5953601 Organelle biogenesis and maintenance
5954333 PPARA activates gene expression
5953326 Phase 1 - Functionalization of compounds
5954224 REV-ERBA represses gene expression
5954225 RORA activates circadian gene expression
5953719 Recycling of bile acids and salts
5954497 Regulation of cholesterol biosynthesis by SREBP (SREBF)
5954222 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5953930 Synthesis of bile acids and bile salts
5953929 Synthesis of bile acids and bile salts via 27-hydroxycholesterol
5953931 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
5953599 Transcriptional activation of mitochondrial biogenesis
5954166 Transcriptional regulation of white adipocyte differentiation
5954528 YAP1- and WWTR1 (TAZ)-stimulated gene expression

Domain Information

InterPro Annotations

Accession Description
IPR010011 Domain of unknown function DUF1518
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR017426 Nuclear receptor coactivator
IPR028819 Nuclear receptor coactivator 1
IPR008955 Nuclear receptor coactivator Src-1
IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
IPR009110 Nuclear receptor coactivator, interlocking
IPR000014 PAS domain
IPR013767 PAS_fold
IPR014935 Steroid receptor coactivator

UniProt Annotations

Entry Information

Gene Name
nuclear receptor coactivator 1
Protein Entry
D4A3Q3_RAT
UniProt ID
D4A3Q3
Species
Rat

Comments

Comment Type Description
Similarity Contains 1 basic helix-loop-helix (bHLH) domain
Similarity Contains bHLH (basic helix-loop-helix) domain

Identical and Related Proteins

Unique RefSeq proteins for LMP013367 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157819661 RefSeq NP_001101482 1417 nuclear receptor coactivator 1

Identical Sequences to LMP013367 proteins

Reference Database Accession Length Protein Name
GI:157819661 GenBank EDM03032.1 1417 nuclear receptor coactivator 1 (predicted), isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP013367 proteins

Reference Database Accession Length Protein Name
GI:157819661 GenBank EDM03032.1 1417 nuclear receptor coactivator 1 (predicted), isoform CRA_a [Rattus norvegicus]
GI:157819661 RefSeq XP_006239904.1 1443 PREDICTED: nuclear receptor coactivator 1 isoform X1 [Rattus norvegicus]
GI:157819661 RefSeq XP_006239905.1 1443 PREDICTED: nuclear receptor coactivator 1 isoform X1 [Rattus norvegicus]
GI:157819661 RefSeq XP_006239906.1 1442 PREDICTED: nuclear receptor coactivator 1 isoform X2 [Rattus norvegicus]