Gene/Proteome Database (LMPD)

LMPD ID
LMP013314
Gene ID
309419
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
Gene Symbol
Pip5k1b
Synonyms
Pip5k1a;
Alternate Names
phosphatidylinositol 4-phosphate 5-kinase type-1 beta; PIP5KIbeta; PIP5K1-beta; PIP5KIalpha; ptdIns(4)P-5-kinase beta; ptdIns(4)P-5-kinase 1 beta; phosphatidylinositol 4-phosphate 5-kinase type I beta; phosphatidylinositol-4-phosphate 5-kinase type-1 beta; phosphatidylinositol 4-phosphate 5-kinase type I alpha; phosphatidylinositol-4-phosphate 5-kinase type I alpha; phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha; phosphatidylinositol-4-phosphate 5-kinase, type 1, beta;
Chromosome
1
Map Location
1q51
EC Number
2.7.1.68

Proteins

phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Refseq ID NP_001012761
Protein GI 60678264
UniProt ID Q5CZZ9
mRNA ID NM_001012743
Length 539
MSSTAENGDAVPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVVESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNPGASGSLFFLTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGGINIRIVVMNNVLPRAMRMHLTYDLKGSTYKRRASRKEREKPNPTFKDLDFLQDMHEGLYFDTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHILDHSLKDKEEEPLQNAPDAKRPGMQKVLYSTAMESIQGPGKSADGIIAENPDTMGGIPAKSHKGEKLLLFMGIIDILQSYRLMKKLEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKATSQEILSSISQEWKDEKQDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTISSSSLYVGEHYPHDRTTLYSNSKGLPSSSTFTLEEGTIYLTAEPNALETQDDASVLDVYL

Gene Information

Entrez Gene ID
309419
Gene Name
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
Gene Symbol
Pip5k1b
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0001931 IEA:Ensembl C uropod
GO:0016308 IEA:UniProtKB-EC F 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding

KEGG Pathway Links

KEGG Pathway ID Description
ko04144 Endocytosis
rno04144 Endocytosis
ko04666 Fc gamma R-mediated phagocytosis
rno04666 Fc gamma R-mediated phagocytosis
ko04510 Focal adhesion
rno04510 Focal adhesion
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
ko04810 Regulation of actin cytoskeleton
rno04810 Regulation of actin cytoskeleton

REACTOME Pathway Links

REACTOME Pathway ID Description
5953253 Disease
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954478 PI Metabolism
5953474 Phospholipid metabolism
5954027 RNF mutants show enhanced WNT signaling and proliferation
5953381 Signal Transduction
5953965 Signaling by WNT in cancer
5953803 Signaling by Wnt
5954499 Synthesis of PIPs at the plasma membrane
5954025 TCF dependent signaling in response to WNT
5954031 WNT mediated activation of DVL
5954028 XAV939 inhibits tankyrase, stabilizing AXIN
5954026 misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling

Domain Information

InterPro Annotations

Accession Description
IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
Protein Entry
PI51B_RAT
UniProt ID
Q5CZZ9
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Caution There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha
Function Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity)
Similarity Contains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
Subcellular Location Endomembrane system . Note=Associated with membranes
Subunit Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1

Identical and Related Proteins

Unique RefSeq proteins for LMP013314 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
60678264 RefSeq NP_001012761 539 phosphatidylinositol 4-phosphate 5-kinase type-1 beta

Identical Sequences to LMP013314 proteins

Reference Database Accession Length Protein Name
GI:60678264 GenBank AAC05374.1 539 type I alpha phosphatidylinositol-4-phosphate 5-kinase variant [Mus musculus]
GI:60678264 GenBank AAH90349.1 539 Phosphatidylinositol-4-phosphate 5-kinase, type I, beta [Rattus norvegicus]
GI:60678264 SwissProt Q5CZZ9.1 539 RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; Short=PIP5K1-beta; Short=PtdIns(4)P-5-kinase 1 beta; AltName: Full=Phosphatidylinositol 4-phosphate 5-kinase type I alpha; Short=PIP5KIalpha; AltName: Full=Phosphatidylinositol 4-phosphate 5-kinase type I beta; Short=PIP5KIbeta [Rattus norvegicus]

Related Sequences to LMP013314 proteins

Reference Database Accession Length Protein Name
GI:60678264 GenBank AAC05374.1 539 type I alpha phosphatidylinositol-4-phosphate 5-kinase variant [Mus musculus]
GI:60678264 GenBank AAH90349.1 539 Phosphatidylinositol-4-phosphate 5-kinase, type I, beta [Rattus norvegicus]
GI:60678264 RefSeq NP_032872.1 539 phosphatidylinositol 4-phosphate 5-kinase type-1 beta [Mus musculus]
GI:60678264 SwissProt Q5CZZ9.1 539 RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; Short=PIP5K1-beta; Short=PtdIns(4)P-5-kinase 1 beta; AltName: Full=Phosphatidylinositol 4-phosphate 5-kinase type I alpha; Short=PIP5KIalpha; AltName: Full=Phosphatidylinositol 4-phosphate 5-kinase type I beta; Short=PIP5KIbeta [Rattus norvegicus]