Gene/Proteome Database (LMPD)

LMPD ID
LMP013312
Gene ID
309262
Species
Rattus norvegicus (Rat)
Gene Name
NAD(P) dependent steroid dehydrogenase-like
Gene Symbol
Nsdhl
Alternate Names
sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating;
Chromosome
X
Map Location
chromosome:X
EC Number
1.1.1.170;

Proteins

sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
Refseq ID NP_001009399
Protein GI 57164113
UniProt ID Q5PPL3
mRNA ID NM_001009399
Length 362
MEQAVRSESKKGQVTGTDLINEVSKAKKCTVIGGSGFLGQHMVEQLLSRGYAVNVFDVRQGFDNPRVQFFIGDLCNQQDLYPALKGVSTVFHCASPPSNSNNKELFYRVNSTGTKTVIETCKEAGVQKLILTSSASVVFEGVDIKNGTEDLPYAMKPIDYYTETKILQERAVLDANDPKKNFLTAAIRPHGIFGPRDPQLVPVLIDAARKGKMKFMIGNGKNLVDFTFVENVVHGHILAAEHLSRDAGLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYRVAYYLAFLLSLLVMVLSPLIQIQTTFTPFRVALAGTFHYYSCEKAKKLIGYRPLVTMDDAVERTVQSFHHLRKDK

Gene Information

Entrez Gene ID
309262
Gene Name
NAD(P) dependent steroid dehydrogenase-like
Gene Symbol
Nsdhl
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005811 IEA:UniProtKB-KW C lipid particle
GO:0003854 IEA:InterPro F 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0047012 IEA:UniProtKB-EC F sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity
GO:0006695 IEA:UniProtKB-KW P cholesterol biosynthetic process
GO:0001942 IEA:Ensembl P hair follicle development
GO:0060716 IEA:Ensembl P labyrinthine layer blood vessel development
GO:0007224 IEA:Ensembl P smoothened signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
M00101 Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
rno01100 Metabolic pathways
ko00100 Steroid biosynthesis
rno00100 Steroid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953924 Cholesterol biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins

Domain Information

InterPro Annotations

Accession Description
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
NAD(P) dependent steroid dehydrogenase-like
Protein Entry
NSDHL_RAT
UniProt ID
Q5PPL3
Species
Rat

Comments

Comment Type Description
Catalytic Activity A 3-beta-hydroxysteroid-4-alpha-carboxylate + NAD(P)(+) = a 3-oxosteroid + CO(2) + NAD(P)H.
Function Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis
Pathway Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 4/6.
Similarity Belongs to the 3-beta-HSD family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein . Lipid droplet . Note=Trafficking through the Golgi is necessary for ER membrane localization

Identical and Related Proteins

Unique RefSeq proteins for LMP013312 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
57164113 RefSeq NP_001009399 362 sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

Identical Sequences to LMP013312 proteins

Reference Database Accession Length Protein Name
GI:57164113 GenBank AAH87626.1 362 NAD(P) dependent steroid dehydrogenase-like [Rattus norvegicus]
GI:57164113 GenBank EDL82839.1 362 NAD(P) dependent steroid dehydrogenase-like [Rattus norvegicus]
GI:57164113 RefSeq XP_006229577.1 362 PREDICTED: sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating isoform X1 [Rattus norvegicus]
GI:57164113 SwissProt Q5PPL3.1 362 RecName: Full=Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating [Rattus norvegicus]

Related Sequences to LMP013312 proteins

Reference Database Accession Length Protein Name
GI:57164113 GenBank AAH87626.1 362 NAD(P) dependent steroid dehydrogenase-like [Rattus norvegicus]
GI:57164113 GenBank EDL82839.1 362 NAD(P) dependent steroid dehydrogenase-like [Rattus norvegicus]
GI:57164113 RefSeq XP_006229577.1 362 PREDICTED: sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating isoform X1 [Rattus norvegicus]
GI:57164113 SwissProt Q5PPL3.1 362 RecName: Full=Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating [Rattus norvegicus]