Gene/Proteome Database (LMPD)

LMPD ID
LMP013310
Gene ID
309207
Species
Rattus norvegicus (Rat)
Gene Name
diacylglycerol lipase, alpha
Gene Symbol
Dagla
Synonyms
Nsddr;
Alternate Names
sn1-specific diacylglycerol lipase alpha; DGL-alpha; neural stem cell-derived dendrite regulator;
Chromosome
1
Map Location
1q43
EC Number
3.1.1.-

Proteins

sn1-specific diacylglycerol lipase alpha
Refseq ID NP_001005886
Protein GI 54312094
UniProt ID Q5YLM1
mRNA ID NM_001005886
Length 1044
MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGRGYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLTQYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTYNLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGLVLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSHEMLRYKEVCYYMLFALAAYGWPMYLMRKPTCGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLDENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVEGHRGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAILSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQLLDVLQRSTKPKWRIIVGATKCIPKSELPEDQVEVTALASTRLWTHPSDLTIALSASTPLYPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGLNKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPLPTGLALELPATEHRNSSVRSKSQSEMSLEGFSEGRLLSPVAAASAARQDPVELLLLSTQERLAAELQSRRAPLATMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRTELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSAANDEEEAAGGSEGGGVAPRGELALHNGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMMVPESPTSDYTEGPKSPSQQEILLRAQFEPNLVPKPPRLFAGSAEPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLATDKIRTSTPTGHGASPTKQDDLVISAR

Gene Information

Entrez Gene ID
309207
Gene Name
diacylglycerol lipase, alpha
Gene Symbol
Dagla
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0019369 IEA:Ensembl P arachidonic acid metabolic process
GO:0046340 IEA:Ensembl P diacylglycerol catabolic process
GO:0071926 IEA:Ensembl P endocannabinoid signaling pathway
GO:0007405 IEA:Ensembl P neuroblast proliferation
GO:0042136 IEA:Ensembl P neurotransmitter biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04723 Retrograde endocannabinoid signaling
rno04723 Retrograde endocannabinoid signaling

REACTOME Pathway Links

REACTOME Pathway ID Description
5954256 Arachidonate production from DAG
5953655 Effects of PIP2 hydrolysis
5953653 G alpha (q) signalling events
5953642 GPCR downstream signaling
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5953645 Hemostasis
5953644 Platelet activation, signaling and aggregation
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR002921 Fungal lipase-like domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol lipase, alpha
Protein Entry
DGLA_RAT
UniProt ID
Q5YLM1
Species
Rat

Comments

Comment Type Description
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ;
Function Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses (By similarity)
Similarity Belongs to the AB hydrolase superfamily. Lipase family
Subcellular Location Cell membrane ; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP013310 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
54312094 RefSeq NP_001005886 1044 sn1-specific diacylglycerol lipase alpha

Identical Sequences to LMP013310 proteins

Reference Database Accession Length Protein Name
GI:54312094 GenBank AAQ17117.1 1044 neural stem cell-derived dendrite regulator [Rattus norvegicus]
GI:54312094 RefSeq XP_008758451.1 1044 PREDICTED: sn1-specific diacylglycerol lipase alpha isoform X1 [Rattus norvegicus]
GI:54312094 RefSeq XP_008758452.1 1044 PREDICTED: sn1-specific diacylglycerol lipase alpha isoform X1 [Rattus norvegicus]
GI:54312094 SwissProt Q5YLM1.1 1044 RecName: Full=Sn1-specific diacylglycerol lipase alpha; Short=DGL-alpha; AltName: Full=Neural stem cell-derived dendrite regulator [Rattus norvegicus]

Related Sequences to LMP013310 proteins

Reference Database Accession Length Protein Name
GI:54312094 GenBank AAQ17117.1 1044 neural stem cell-derived dendrite regulator [Rattus norvegicus]
GI:54312094 RefSeq XP_008758451.1 1044 PREDICTED: sn1-specific diacylglycerol lipase alpha isoform X1 [Rattus norvegicus]
GI:54312094 RefSeq XP_008758452.1 1044 PREDICTED: sn1-specific diacylglycerol lipase alpha isoform X1 [Rattus norvegicus]
GI:54312094 SwissProt Q5YLM1.1 1044 RecName: Full=Sn1-specific diacylglycerol lipase alpha; Short=DGL-alpha; AltName: Full=Neural stem cell-derived dendrite regulator [Rattus norvegicus]