Gene/Proteome Database (LMPD)
LMPD ID
LMP013291
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
Vac14 homolog (S. cerevisiae)
Gene Symbol
Alternate Names
protein VAC14 homolog; vacuole 14 protein;
Chromosome
19
Map Location
19q12
Summary
a putative cytoskeletal interacting protein; mutation of gene may be associated with lethal communicating hydrocephalus with perinatal onset [RGD, Feb 2006]
Orthologs
Proteins
| protein VAC14 homolog | |
|---|---|
| Refseq ID | NP_808791 |
| Protein GI | 29293817 |
| UniProt ID | Q80W92 |
| mRNA ID | NM_177930 |
| Length | 783 |
| MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVRDFVAQNNTVQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESSKFDLVGFIPLLRERIYSNNQYARQFIISWILVLVSVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTTDDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEVANVCNQSLMKLVTPEDDEPDEPKSVAQKQTEPNPEDSLPKQEGTASGGASGPCDSSFGSGISVFTSASTDRAPVTLHLDGIVQVLNCHLSDTTIGMMTRIAVLKWLYHLYIKTPRKMFRHTDSLFPILLQTLSDESDEVVLKDLEVLAEIASSPAGQTDDPGAPDGPDLQVNHSELQVPTSGRANLLNPPNTKGLECSPSTPTMNSYFYKFMINLLQTFSSERKLLEARGPFIIRQLCLLLNAENIFHSMADILLREEDLKFASTMVHTLNTILLTSTELFQLRNQLKDLKTLESQNLFCCLYRSWCHNPVTTVSLCFLTQNYRHAYDLIQKFGDLEVTVDFLTEVDKLVQLIECPIFTYLRLQLLDVKNNPYLMKALYGLLMLLPQSSAFQLLSHRLQCVPNPELLQTEDCLKAAPKSQKGDSPSIDYTELLQHFEKVQKQHLEVRHQRSGRGDHLDRRVVL | |
Gene Information
Entrez Gene ID
Gene Name
Vac14 homolog (S. cerevisiae)
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0070772 | IEA:InterPro | C | PAS complex |
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0010008 | IEA:Ensembl | C | endosome membrane |
| GO:0043550 | IEA:InterPro | P | regulation of lipid kinase activity |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko05166 | HTLV-I infection |
| rno05166 | HTLV-I infection |
| ko05203 | Viral carcinogenesis |
| rno05203 | Viral carcinogenesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5953250 | Metabolism |
| 5953289 | Metabolism of lipids and lipoproteins |
| 5954478 | PI Metabolism |
| 5953474 | Phospholipid metabolism |
| 5954502 | Synthesis of PIPs at the Golgi membrane |
| 5954503 | Synthesis of PIPs at the early endosome membrane |
| 5954500 | Synthesis of PIPs at the late endosome membrane |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Developmental Stage | Expressed in embryonic brain |
| Domain | The C-terminal domain (residues 524-783) mediates homomeric interactions and is necessary for the formation and maintenance of the PI(3,5)P2 regulatory complex |
| Function | The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes (By similarity) |
| Similarity | Belongs to the VAC14 family |
| Similarity | Contains 6 HEAT repeats |
| Subcellular Location | Endosome membrane . Microsome membrane . Note=Mainly associated with membranes of the late endocytic pathway |
| Subunit | Forms homooligomers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold (By similarity). Interacts with NOS1. {ECO:0000250, ECO:0000269|PubMed:17161399}. |
| Tissue Specificity | Expressed in brain, lung, kidney and testis with highest levels in brain and testis |
Identical and Related Proteins
Unique RefSeq proteins for LMP013291 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 29293817 | RefSeq | NP_808791 | 783 | protein VAC14 homolog |
Identical Sequences to LMP013291 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:29293817 | GenBank | AAO48767.1 | 783 | VAC14 [Rattus norvegicus] |
| GI:29293817 | GenBank | EDL92542.1 | 783 | Vac14 homolog (S. cerevisiae), isoform CRA_b [Rattus norvegicus] |
| GI:29293817 | SwissProt | Q80W92.1 | 783 | RecName: Full=Protein VAC14 homolog [Rattus norvegicus] |
Related Sequences to LMP013291 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:29293817 | GenBank | AAO48767.1 | 783 | VAC14 [Rattus norvegicus] |
| GI:29293817 | GenBank | EDL92541.1 | 775 | Vac14 homolog (S. cerevisiae), isoform CRA_a [Rattus norvegicus] |
| GI:29293817 | GenBank | EDL92542.1 | 783 | Vac14 homolog (S. cerevisiae), isoform CRA_b [Rattus norvegicus] |
| GI:29293817 | SwissProt | Q80W92.1 | 783 | RecName: Full=Protein VAC14 homolog [Rattus norvegicus] |