Gene/Proteome Database (LMPD)

LMPD ID
LMP013282
Gene ID
306808
Species
Rattus norvegicus (Rat)
Gene Name
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Gene Symbol
Ippk
Synonyms
rIpk1; C9orf12; RGD1311271;
Alternate Names
inositol-pentakisphosphate 2-kinase; insP5 2-kinase; ins(1,3,4,5,6)P5 2-kinase; inositol polyphosphate kinase 1; 1,3,4,5,6-pentakisphosphate 2-kinase; inositol-1,3,4,5,6-pentakisphosphate 2-kinase;
Chromosome
17
Map Location
17p14
EC Number
2.7.1.158

Proteins

inositol-pentakisphosphate 2-kinase
Refseq ID NP_001008556
Protein GI 56676358
UniProt ID Q5PXE9
mRNA ID NM_001008556
Length 489
MEEGKMDENEWSYHGEGNKSLVVAHAQRCVVLRFLKFPPNKKKTSEEILQHLQNIVDFGKNVMKDFLGENYVHCGEVVQLPLEFVKQLCLKIQCERPESRCDKDLDTLSGYAMCLPNLTRLQTFPFAEHRPILCVEIKPKCGFIPFSNGVTHEMKHKVCRYCMHQHLKVATGKWKKISKYCPLDLYSGNKQRMHFALKSLLQEAQNNLRIFKNGELIYGCADARSPVADLKALAHHLKPFFFPSNGLASGPQCTRAVIRELVHVITRVLLSTSDKGRAGALRLGLQGARVCEASPFSRSLHHQGKNTPEHSGLPKGCLLYKTLQVQMLDQLDIEGLYPLYNRVEQYLEEFPEERKTLQIDGPYDEVFYQKLLDLSTEDDGTVAFALTKVQQYRVAMTAKDCSIMIALSPCLQGASSDQRPVIPSSRSRLAFSVSVLDLDLKPYESIPHQYKLDSKIVSYYSKTVHAKDDTVRSTRFKEHEDCTLVLHKV

Gene Information

Entrez Gene ID
306808
Gene Name
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Gene Symbol
Ippk
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0035299 ISS:HGNC F inositol pentakisphosphate 2-kinase activity
GO:0052746 ISS:BHF-UCL P inositol phosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

Domain Information

InterPro Annotations

Accession Description
IPR009286 Inositol-pentakisphosphate 2-kinase

UniProt Annotations

Entry Information

Gene Name
inositol 1,3,4,5,6-pentakisphosphate 2-kinase
Protein Entry
IPPK_RAT
UniProt ID
Q5PXE9
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate
Domain The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.
Function Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis
Similarity Belongs to the IPK1 type 2 family
Subcellular Location Cytoplasm . Nucleus .

Identical and Related Proteins

Unique RefSeq proteins for LMP013282 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
56676358 RefSeq NP_001008556 489 inositol-pentakisphosphate 2-kinase

Identical Sequences to LMP013282 proteins

Reference Database Accession Length Protein Name
GI:56676358 GenBank AAV76010.1 489 inositol polyphosphate kinase 1 [Rattus norvegicus]
GI:56676358 SwissProt Q5PXE9.1 489 RecName: Full=Inositol-pentakisphosphate 2-kinase; AltName: Full=Inositol-1,3,4,5,6-pentakisphosphate 2-kinase; AltName: Full=Ins(1,3,4,5,6)P5 2-kinase; Short=InsP5 2-kinase; Short=rIPK1 [Rattus norvegicus]

Related Sequences to LMP013282 proteins

Reference Database Accession Length Protein Name
GI:56676358 GenBank AAV76010.1 489 inositol polyphosphate kinase 1 [Rattus norvegicus]
GI:56676358 GenBank EDL98114.1 489 inositol 1,3,4,5,6-pentakisphosphate 2-kinase [Rattus norvegicus]
GI:56676358 RefSeq XP_003505388.1 489 PREDICTED: inositol-pentakisphosphate 2-kinase isoform X1 [Cricetulus griseus]
GI:56676358 SwissProt Q5PXE9.1 489 RecName: Full=Inositol-pentakisphosphate 2-kinase; AltName: Full=Inositol-1,3,4,5,6-pentakisphosphate 2-kinase; AltName: Full=Ins(1,3,4,5,6)P5 2-kinase; Short=InsP5 2-kinase; Short=rIPK1 [Rattus norvegicus]