Gene/Proteome Database (LMPD)

LMPD ID
LMP013281
Gene ID
306792
Species
Rattus norvegicus (Rat)
Gene Name
sphingosine-1-phosphate receptor 3
Gene Symbol
S1pr3
Synonyms
Edg3; lpb3; Edg3l;
Alternate Names
sphingosine 1-phosphate receptor 3; cardiac sphingosine-1-phosphate specific receptor; endothelial differentiation, sphingolipid G-protein-coupled receptor, 3;
Chromosome
17
Map Location
17p14
Summary
mouse homolog is a G-protein coupled receptor for sphingosine 1-phosphate [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for S1pr3

Proteins

sphingosine 1-phosphate receptor 3
Refseq ID NP_001258072
Protein GI 403044532
UniProt ID F1M9D3
mRNA ID NM_001271143
Length 379
MASTHAQGHPPVLGNDTLREHYDYVGKLAGRLRDPPEGSTLITTILFLVTCSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGRKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKKHRVFLLIGMCWLIAFSLGALPILGWNCLENFPDCSTILPLYSKKYIAFLISIFTAILVTIVILYARIYFLVKSSSRRVANHNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRAKECSILFKSQWFIMLAVLNSAMNPVIYTLASKEMRRAFFRLVCGCLVKGKGTQASPMQPALDPSRSKSSSSNNSSSHSPKVKEDLPHVATSSCVTDKTRSLQNGVLCK

Gene Information

Entrez Gene ID
306792
Gene Name
sphingosine-1-phosphate receptor 3
Gene Symbol
S1pr3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:Ensembl C plasma membrane
GO:0038036 IEA:InterPro F sphingosine-1-phosphate receptor activity
GO:0007193 IEA:Ensembl P adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0001816 IEA:Ensembl P cytokine production
GO:0006954 IEA:Ensembl P inflammatory response
GO:1903141 IEA:Ensembl P negative regulation of establishment of endothelial barrier
GO:0032651 IEA:Ensembl P regulation of interleukin-1 beta production

KEGG Pathway Links

KEGG Pathway ID Description
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5954152 G alpha (i) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5954244 Lysosphingolipid and LPA receptors
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR004062 EDG-3 sphingosine 1-phosphate receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR004061 Sphingosine 1-phosphate receptor

UniProt Annotations

Entry Information

Gene Name
sphingosine-1-phosphate receptor 3
Protein Entry
F1M9D3_RAT
UniProt ID
F1M9D3
Species
Rat

Comments

Comment Type Description
Caution The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data
Similarity Belongs to the G-protein coupled receptor 1 family

Identical and Related Proteins

Unique RefSeq proteins for LMP013281 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
403044532 RefSeq NP_001258072 379 sphingosine 1-phosphate receptor 3

Identical Sequences to LMP013281 proteins

Reference Database Accession Length Protein Name
GI:403044532 RefSeq XP_006253740.1 379 PREDICTED: sphingosine 1-phosphate receptor 3 isoform X1 [Rattus norvegicus]
GI:403044532 RefSeq XP_006253741.1 379 PREDICTED: sphingosine 1-phosphate receptor 3 isoform X1 [Rattus norvegicus]
GI:403044532 RefSeq XP_008769718.1 379 PREDICTED: sphingosine 1-phosphate receptor 3 isoform X1 [Rattus norvegicus]

Related Sequences to LMP013281 proteins

Reference Database Accession Length Protein Name
GI:403044532 GenBank AED03609.1 379 Sequence 29 from patent US 7871815
GI:403044532 RefSeq XP_006253740.1 379 PREDICTED: sphingosine 1-phosphate receptor 3 isoform X1 [Rattus norvegicus]
GI:403044532 RefSeq XP_006253741.1 379 PREDICTED: sphingosine 1-phosphate receptor 3 isoform X1 [Rattus norvegicus]
GI:403044532 RefSeq XP_008769718.1 379 PREDICTED: sphingosine 1-phosphate receptor 3 isoform X1 [Rattus norvegicus]