Gene/Proteome Database (LMPD)

LMPD ID
LMP013280
Gene ID
306764
Species
Rattus norvegicus (Rat)
Gene Name
nuclear receptor binding SET domain protein 1
Gene Symbol
Nsd1
Alternate Names
histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific;
Chromosome
17
Map Location
17p14

Proteins

histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
Refseq ID NP_001100807
Protein GI 157822347
UniProt ID D4AA06
mRNA ID NM_001107337
Length 2381
MCHPKKKSTPLKYEVGDLIWAKFKRRPWWPCRICSDPLINTHSKMKVANRRPYREYYVEAFGDPSEKAWVAGKAIVMFEGRHQFEELPVLRKRGKQKEKGYRHKVPQKILSKWEASVGLAEQCDVPRGPKTQKCVPSSAKLDSEEDMPFEDCANDPDSEHDLLLNGCLKSLAFDSEHSADEKEKPCAKSRVRKSSDNIKRTSVKKGLMPFEAQKEERRGKSPENLGLDFLSGGVSDKQASNELSRIANSLTGSSAAPGQFLFSSCGQNTAKTDFETPNCDSLSGLSESALISKHSGEKKKLQPGQVCSSKVQLCYVGAGDEEKRSDSVSVCTTSDDGSSDLDPTEHNSEFHKSVLEVTDALDKTENALSMHKNETKYSRYPATNRVKEKQKSLITNSHTDHLMDSTKTVEPGTAEISQVNLSDLKISSPIPKPQPEFRNDGLTTKFNAPPGIRNENSLTKGGLANQTLLPLKCRQPKFRSIKCKHKESPTAAETSATSEDLSLKCCSSDTNGSPMTSISKSGKGEGLKLLNNMHEKTRDSSDIETAVVKHVLSELKELSYRSLSEDVSDSGTSKSSKPLLFSSASSQNHIPIEPDYKFSTLLMMLKDMHDSKTKEQRLMTAQNVASYRTPDRGDCSSGSPVGTSKVLVLGGSTHNSEKPGDSTQDSVRLSPGGGDSALSGELSSSLSVLPSDKRDLPACGKIRSNCIPRRNCGRAKLSPKLRVTISTQMAKPSVNPKALKTERKRKLSRLPAVTLAANGLGNKESGGSVNGPLKGGAQDPAKEEPLQQMDLLRNEETHFDSKVKQSDPDKILEKEPSFENRKGPEVGSEINIENDEPHGVDQVVPKKRWQRLNQRRPKPGKRASRFREKENSEGAFGVLLPGDPVQKGRDDYLEQRAPPTSILEDSAADPNHVSHSESVGPRLNVCDKSSVSMGDLEKETGIPSLTPQTKIPEPAVRSEKKRLRKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSSRCEDESLLARCRSSAQNKQVDENSLISTKEEPPVLEREAPFLEGPLVQSDLGVAHAELPQLTLSVPVAPEVSPRPTLESEELLVKTPGNYEGKRQRKPTKKLLESNDLDPGFMPKKGDLGLSRKCCESGHLENGVGDSRATPHLKEFGGGTTRIFDKPRKRKRQRHGTARVHYKRVKKEDSARETPSSAEGELMIHRTAASPKEILEEGIEHDPGMSASKRLQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTEMPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVVQNKGFRCPLHICITCHAANPANVSASKGRLMRCVRCPVAYHANDFCLAAGSKILASNSIICPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWYCNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAAARFEELKAQKELRQLQEDRKNDKKPPPYKHIKVNRPIGRVQIFTADLSEIPRCNCKATDENPCGIDSECINRMLLYECHPTVCPAGGRCQNQCFSKRQYPDVEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLGVRPKNQPIVTEEKSRKFKRKPHGKRRSQGEVTKEREDECFSCGDGGQLVSCKKPGCPKVYHADCLNLTKRPAGKWECPWHQCDVCGKEAASFCEMCPSSFCKQHREGMLFISKLDGRLSCTEHDPCGPNPLEPGEIREYVPPTATLSPSPGTQQTEQSSEMGTQGPKKSDQPPTDATQMLSLSKKAVTGTCQRPLLPERPPERTDSSSHLLDRIRDLAGSGTKSQSLVSSQRPQDRPPAKEGPRPQPPDRASPVTRPSSSPSVSSLPLERPLRMTEPRLDKSIGAASPKSQAVEKPPAPTGLRLSSPDRLLNTNSPKPQISDRPPDKSHASLTQRLPPPEKVLSAVVQSLVAKEKALRPVDQNTQAKHRAAVVMDLIDLTPRQKERAASPQEVTAQADEKTPVLESSSRPTSRGLGHVPRAVEKGGVSDPLQPPGKSAAPSEHPWQAVKSLTHARFLSPPSAKAFLYESAIQASGRAPVGSEQTPGPPSPAPGLLKQVKQLSRGLTAKSGQSFRSLGKISASLPNEEKKLTTTEQSPWGLGKASPGAGLWPIVAGQTLAQACWSSGGTQTLAQNCWSLGRGQDPKPEQNAIQALNQAPSSRKCAESEQK

Gene Information

Entrez Gene ID
306764
Gene Name
nuclear receptor binding SET domain protein 1
Gene Symbol
Nsd1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0003682 IEA:Ensembl F chromatin binding
GO:0018024 IEA:InterPro F histone-lysine N-methyltransferase activity
GO:0003712 IEA:Ensembl F transcription cofactor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0001702 IEA:Ensembl P gastrulation with mouth forming second
GO:0045893 IEA:Ensembl P positive regulation of transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
ko00310 Lysine degradation
rno00310 Lysine degradation

Domain Information

InterPro Annotations

Accession Description
IPR006560 AWS domain
IPR000313 PWWP domain
IPR003616 Post-SET domain
IPR001214 SET domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger
IPR001965 Zinc finger, PHD-type
IPR019786 Zinc finger, PHD-type, conserved site
IPR001841 Zinc finger, RING-type
IPR013083 Zinc finger, RING/FYVE/PHD-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor binding SET domain protein 1
Protein Entry
D4AA06_RAT
UniProt ID
D4AA06
Species
Rat

Comments

Comment Type Description
Catalytic Activity S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]
Similarity Contains 1 SET domain
Similarity Contains 1 post-SET domain
Similarity Contains SET domain
Similarity Contains post-SET domain

Identical and Related Proteins

Unique RefSeq proteins for LMP013280 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157822347 RefSeq NP_001100807 2381 histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific

Identical Sequences to LMP013280 proteins

Reference Database Accession Length Protein Name
GI:157822347 GenBank EDL94004.1 2381 nuclear receptor binding SET domain protein 1 (predicted), isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP013280 proteins

Reference Database Accession Length Protein Name
GI:157822347 GenBank EDL94004.1 2381 nuclear receptor binding SET domain protein 1 (predicted), isoform CRA_a [Rattus norvegicus]
GI:157822347 RefSeq XP_006253682.1 2689 PREDICTED: histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X1 [Rattus norvegicus]
GI:157822347 RefSeq XP_006253683.1 2689 PREDICTED: histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X1 [Rattus norvegicus]
GI:157822347 RefSeq XP_008769714.1 2384 PREDICTED: histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X3 [Rattus norvegicus]