Gene/Proteome Database (LMPD)

LMPD ID
LMP013272
Gene ID
306257
Species
Rattus norvegicus (Rat)
Gene Name
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Gene Symbol
Bap1
Alternate Names
ubiquitin carboxyl-terminal hydrolase BAP1; BRCA1-associated protein 1; Brca1 associated protein 1;
Chromosome
16
Map Location
16p16
EC Number
3.4.19.12

Proteins

ubiquitin carboxyl-terminal hydrolase BAP1
Refseq ID NP_001100762
Protein GI 157822067
UniProt ID D3ZHS6
mRNA ID NM_001107292
Length 740
MNKGWLELESDPGLFTLLVEDFGKNPFTPDRRALAGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNSMFFAHQLIPNSCATHALLSVLLNCSNVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRVKYEARLHVLKGNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKPASSKSPFGLEAGRTPAASECTHTDGAEEVAGSCPQTTTHSPPSKSKLVVKPSGSSLNGVPPTPTPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRPQQYSDDEEDYEDEEEDVQNTSSAIRYKRKGTGKPGSLSNSSDGQLSVLQPNTINVLTEKLQESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSTRSSQGSQGSSSLEEKEVVEVTDSRDKSGLNRSSEPLSGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ

Gene Information

Entrez Gene ID
306257
Gene Name
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Gene Symbol
Bap1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0035517 ISS:UniProtKB C PR-DUB complex
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0005634 ISS:UniProtKB C nucleus
GO:0003682 ISS:UniProtKB F chromatin binding
GO:0004221 ISS:UniProtKB F ubiquitin thiolesterase activity
GO:0004843 ISS:UniProtKB F ubiquitin-specific protease activity
GO:0035522 ISS:UniProtKB P monoubiquitinated histone H2A deubiquitination
GO:0035520 ISS:UniProtKB P monoubiquitinated protein deubiquitination
GO:0071108 ISS:UniProtKB P protein K48-linked deubiquitination
GO:0016579 ISS:UniProtKB P protein deubiquitination
GO:0051726 ISS:UniProtKB P regulation of cell cycle
GO:0001558 ISS:UniProtKB P regulation of cell growth
GO:0006511 IEA:InterPro P ubiquitin-dependent protein catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR001578 Peptidase_C12_UCH

UniProt Annotations

Entry Information

Gene Name
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Protein Entry
BAP1_RAT
UniProt ID
D3ZHS6
Species
Rat

Comments

Comment Type Description
Catalytic Activity Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Function Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration. Acts as a tumor suppressor (By similarity)
Ptm Ubiquitinated: monoubiquitinated at multiple site of its nuclear localization signal (NLS) by UBE2O, leading to cytoplasmic retention. Able to mediate autodeubiquitination via intramolecular interactions to couteract cytoplasmic retention (By similarity)
Sequence Caution Sequence=EDL88955.1; Type=Erroneous gene model prediction; Evidence= ;
Similarity Belongs to the peptidase C12 family. BAP1 subfamily
Subcellular Location Cytoplasm . Nucleus . Note=Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (By similarity)
Subunit Component of the PR-DUB complex, at least composed of BAP1 and ASXL1. Interacts with BRCA1 (via the RING finger). Interacts (via HBM-like motif) with HCFC1 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP013272 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157822067 RefSeq NP_001100762 740 ubiquitin carboxyl-terminal hydrolase BAP1

Identical Sequences to LMP013272 proteins

Reference Database Accession Length Protein Name
GI:157822067 GenBank EDL88955.1 740 Brca1 associated protein 1 (predicted) [Rattus norvegicus]

Related Sequences to LMP013272 proteins

Reference Database Accession Length Protein Name
GI:157822067 GenBank EDL24803.1 768 Brca1 associated protein 1, isoform CRA_b, partial [Mus musculus]
GI:157822067 GenBank EDL88955.1 740 Brca1 associated protein 1 (predicted) [Rattus norvegicus]
GI:157822067 RefSeq XP_006252668.1 727 PREDICTED: ubiquitin carboxyl-terminal hydrolase BAP1 isoform X1 [Rattus norvegicus]
GI:157822067 SwissProt D3ZHS6.2 727 RecName: Full=Ubiquitin carboxyl-terminal hydrolase BAP1; AltName: Full=BRCA1-associated protein 1 [Rattus norvegicus]