Gene/Proteome Database (LMPD)

LMPD ID
LMP013247
Gene ID
304542
Species
Rattus norvegicus (Rat)
Gene Name
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
Gene Symbol
Coq5
Synonyms
RGD1310857;
Alternate Names
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; ubiquinone biosynthesis methyltransferase COQ5, mitochondrial;
Chromosome
12
Map Location
12q16
EC Number
2.1.1.201

Proteins

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor
Refseq ID NP_001034111
Protein GI 84781656
UniProt ID Q4G064
mRNA ID NM_001039022
Length 327
MAAPRSCVLWSYCGHGWSRLAGDCRLPGFRRSWLGATLSARSLSQEKRAAETHFGFETVSEKEKGGKVYQVFQSVARKYDLMNDMMSLGIHRAWKDLLIRKMHPLPGTQLLDVAGGTGDIAFRFLSYVQTQHERKQRRQLRTRQNLSWEEIARKYQSKEDPLGGSLVMVCDINREMLKVGKQKALARGHTAGLAWVLGDAEELPFDDDRFDVYTIAFGIRNVTHIDRALQEAHRVLKPGGRFLCLEFSQVNDPLISRLYDLYSFQVIPVIGEVIAGDWKSYQYLVESIRKFPNQEEFKDMIEDAGFQKVTYESLTSGIVAIHSGFKL
transit_peptide: 1..49 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q4G064.1) calculated_mol_wt: 5453 peptide sequence: MAAPRSCVLWSYCGHGWSRLAGDCRLPGFRRSWLGATLSARSLSQEKRA mat_peptide: 50..327 product: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q4G064.1) calculated_mol_wt: 31866 peptide sequence: AETHFGFETVSEKEKGGKVYQVFQSVARKYDLMNDMMSLGIHRAWKDLLIRKMHPLPGTQLLDVAGGTGDIAFRFLSYVQTQHERKQRRQLRTRQNLSWEEIARKYQSKEDPLGGSLVMVCDINREMLKVGKQKALARGHTAGLAWVLGDAEELPFDDDRFDVYTIAFGIRNVTHIDRALQEAHRVLKPGGRFLCLEFSQVNDPLISRLYDLYSFQVIPVIGEVIAGDWKSYQYLVESIRKFPNQEEFKDMIEDAGFQKVTYESLTSGIVAIHSGFKL

Gene Information

Entrez Gene ID
304542
Gene Name
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
Gene Symbol
Coq5
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0008168 IEA:UniProtKB-KW F methyltransferase activity
GO:0006744 IEA:UniProtKB-UniPathway P ubiquinone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00130 Ubiquinone and other terpenoid-quinone biosynthesis
rno00130 Ubiquinone and other terpenoid-quinone biosynthesis
M00128 Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone

REACTOME Pathway Links

REACTOME Pathway ID Description
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954558 Ubiquinol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
IPR004033 UbiE/COQ5 methyltransferase
IPR023576 UbiE/COQ5 methyltransferase, conserved site

UniProt Annotations

Entry Information

Gene Name
coenzyme Q5 homolog, methyltransferase (S. cerevisiae)
Protein Entry
COQ5_RAT
UniProt ID
Q4G064
Species
Rat

Comments

Comment Type Description
Catalytic Activity S-adenosyl-L-methionine + 2-methoxy-6-all- trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6- methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.
Function Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2)
Pathway Cofactor biosynthesis; ubiquinone biosynthesis.
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiE family
Subcellular Location Mitochondrion .

Identical and Related Proteins

Unique RefSeq proteins for LMP013247 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
84781656 RefSeq NP_001034111 327 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor

Identical Sequences to LMP013247 proteins

Reference Database Accession Length Protein Name
GI:84781656 GenBank AAH98719.1 327 Coenzyme Q5 homolog, methyltransferase (S. cerevisiae) [Rattus norvegicus]
GI:84781656 SwissProt Q4G064.1 327 RecName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; AltName: Full=Ubiquinone biosynthesis methyltransferase COQ5; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013247 proteins

Reference Database Accession Length Protein Name
GI:84781656 GenBank AAH98719.1 327 Coenzyme Q5 homolog, methyltransferase (S. cerevisiae) [Rattus norvegicus]
GI:84781656 RefSeq XP_005079029.1 327 PREDICTED: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial [Mesocricetus auratus]
GI:84781656 RefSeq XP_005344360.1 327 PREDICTED: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial [Microtus ochrogaster]
GI:84781656 SwissProt Q4G064.1 327 RecName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; AltName: Full=Ubiquinone biosynthesis methyltransferase COQ5; Flags: Precursor [Rattus norvegicus]