Gene/Proteome Database (LMPD)
Proteins
| sn1-specific diacylglycerol lipase beta | |
|---|---|
| Refseq ID | NP_001100590 |
| Protein GI | 157820071 |
| mRNA ID | NM_001107120 |
| Length | 668 |
| MPGMVLFGRRWSLASDDLVFPGSFELFLRVLWWIASLTLYLMHRRKLDCPGGVLLSTYLIVLLVLLAVIIGIVLAIVCVSMRGTICNPGPRKSMSKLLYIRLALFLPEMVWASLGAAWVAKGIQCDRTVVIGIIATVIVSWIVIAATMVTIVFVFDPLGGKMAPYPPCIPEHLDSNSSNHLLTGLRTAAKSVWETRVQCCCCCIGQDDNTRVAFSSTADLFSTYFSDTDLVPSDIAAGFTLLHQQQDKISHSREPSEVVTHTPGQPQETELDAEVENCHHYMPFAAAAYGWPLYIYRNPFTGLCRIGGDCCRGRDIEYDAVEGDEHHCHFASILKTTGLQYRDFIHVSFHDKVYELPFIVVLDHRKESVVVAVRGTMSLQDVLTDLSAESENLELDIELQDCVAHKGIAQAARYIYRRLVNDGILSQAFSVAPEYRLVVVGHSLGAGAAALLAIMLRGAYPQVRAYAFSPPRGLLSKSLFEYSKDFVVSLILGMDVIPRLSVANMEDLKRRILRVIANCNKPKYKILLHGCWYSVFGGSPDNFPTELDEGNQGALTQPLLGEQTLLTRCSPGYCSGDSPLDSPKYPTLYPPGRIIHLEEEGGSGRFGCCSAAQYRARWAHETEFSKILIGPKMLIDHMPDVMIRALDRVVADRTACVSCPGQGGSNVP | |
Gene Information
Entrez Gene ID
Gene Name
diacylglycerol lipase, beta
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0016787 | IEA:UniProtKB-KW | F | hydrolase activity |
| GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0006810 | IEA:InterPro | P | transport |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko04723 | Retrograde endocannabinoid signaling |
| rno04723 | Retrograde endocannabinoid signaling |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5954256 | Arachidonate production from DAG |
| 5953655 | Effects of PIP2 hydrolysis |
| 5953653 | G alpha (q) signalling events |
| 5953642 | GPCR downstream signaling |
| 5953537 | Gastrin-CREB signalling pathway via PKC and MAPK |
| 5953645 | Hemostasis |
| 5953644 | Platelet activation, signaling and aggregation |
| 5953381 | Signal Transduction |
| 5953391 | Signaling by GPCR |
Domain Information
UniProt Annotations
Entry Information
Gene Name
diacylglycerol lipase, beta
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; |
| Function | Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses (By similarity). {ECO:0000250}. |
| Similarity | Belongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in corticostriatal and hippocampal slices. Highly expressed in striatal neurons (at protein level). {ECO:0000269|PubMed:16051747}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP013241 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 157820071 | RefSeq | NP_001100590 | 668 | sn1-specific diacylglycerol lipase beta |
Identical Sequences to LMP013241 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:157820071 | GenBank | EDL89667.1 | 668 | similar to KCCR13L (predicted) [Rattus norvegicus] |
Related Sequences to LMP013241 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:157820071 | GenBank | AAH16105.2 | 669 | Diacylglycerol lipase, beta [Mus musculus] |
| GI:157820071 | GenBank | EDL89667.1 | 668 | similar to KCCR13L (predicted) [Rattus norvegicus] |
| GI:157820071 | RefSeq | XP_008767183.1 | 669 | PREDICTED: sn1-specific diacylglycerol lipase beta isoform X1 [Rattus norvegicus] |
| GI:157820071 | SwissProt | P0C1S9.1 | 668 | RecName: Full=Sn1-specific diacylglycerol lipase beta; Short=DGL-beta [Rattus norvegicus] |