Gene/Proteome Database (LMPD)

LMPD ID
LMP013077
Gene ID
291567
Species
Rattus norvegicus (Rat)
Gene Name
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Gene Symbol
Ppargc1b
Synonyms
Perc; PGC1beta;
Alternate Names
peroxisome proliferator-activated receptor gamma coactivator 1-beta; PGC-1-beta; PPARGC-1-beta; PPAR-gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; peroxisome proliferative activated receptor, gamma, coactivator 1 beta;
Chromosome
18
Map Location
18q12.1

Proteins

peroxisome proliferator-activated receptor gamma coactivator 1-beta
Refseq ID NP_788264
Protein GI 28570176
UniProt ID Q811R2
mRNA ID NM_176075
Length 990
MQGEGKGGESGEEQLCADLPELDLSQLDASDFDSATCFGELQWCPETSETEPSQYSPDDSEFFQIDSENEALLAALTKTLDDIPEDDVGLAAFPGLDEGDTPSCTPASPAPLSVPPSPALERLLSPVSEVDELSLLQKLLLATSSPTASSDALKDGATWSQTSLSSRSQRPCVKVDGTQDKKTPMLRSQSRPCTELHKHLTSVLPCPRGKACSPPPHPSPQLLSKEDEEVGEDCPSPWPAPASPQDSLGQDTANPNSAQVPKDDVRAMVQLIRYMHTYCLPQRKLPQRASEPIPQSCSSPLRKVPPRSRQTPKAFWTEFSILRELLAQDILCDVSKPYRLATPVYASLTPQSRTRPPKDSQASPAHSAMAEEVRITASPKSTGPRPSLRPLRLEVKRDVNKPARQKREEDEEEEEEEEEEEEKEDEEEEWGRKRPGRGLPWTKLGRKMDSSVCPVRRSRRLNPELGPWLTFTDEPLGALPSMCLATETHDLEEELGGLTDSSQGQQLPLGSQIPTLESPCESGCGDTDEDPSCPRPPSRDSPRCLMLALSQSDPLGKKSFEESLTVELCGTAGLTPPTTPPYKPMEEDPFKQDTKHSPGQDTAPSLPSPETLQLTATPGASHKLPKRHPERSELLSHLQHATTQPVSQAGQKRPFSCSFGDHDYCQVIRPEAALQRKVLRSWEPIKVHLEDLAHQGATLPVETKTPRREADQNCDPTPKDSMQLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLLEEEEEEGGEEDDEGEDSGVSPPCSDHCPYQSPPSKASRQLCSRSRSSSGSSSCSSWSPATRKNFRLESRGPCSDGTPSARHAKKRREKAIGEGRVVYIRNLSGDMSSRELKKRFEVFGEIVECQVLRRSKRGQKHGFITFRCSEHAALSVRNGATLRKRNEPSFHLSYGGLRHFRWPRYTDYDPTSEESLPSSGKSKYEAMDFDSLLKEAQQSLH

Gene Information

Entrez Gene ID
291567
Gene Name
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Gene Symbol
Ppargc1b
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016592 IEA:Ensembl C mediator complex
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005634 ISS:UniProtKB C nucleus
GO:0050682 ISS:UniProtKB F AF-2 domain binding
GO:0003723 IEA:UniProtKB-KW F RNA binding
GO:0001104 IEA:Ensembl F RNA polymerase II transcription cofactor activity
GO:0030374 ISS:UniProtKB F ligand-dependent nuclear receptor transcription coactivator activity
GO:0000166 IEA:InterPro F nucleotide binding
GO:0030546 IEA:Ensembl F receptor activator activity
GO:0007015 IEA:Ensembl P actin filament organization
GO:0060346 IEA:Ensembl P bone trabecula formation
GO:0034614 IEA:Ensembl P cellular response to reactive oxygen species
GO:0030520 ISS:UniProtKB P intracellular estrogen receptor signaling pathway
GO:0045892 IEA:Ensembl P negative regulation of transcription, DNA-templated
GO:0001503 IEA:Ensembl P ossification
GO:0010694 IEA:Ensembl P positive regulation of alkaline phosphatase activity
GO:0045780 IEA:Ensembl P positive regulation of bone resorption
GO:0045672 IEA:Ensembl P positive regulation of osteoclast differentiation
GO:0042327 IEA:Ensembl P positive regulation of phosphorylation
GO:0045944 ISS:UniProtKB P positive regulation of transcription from RNA polymerase II promoter
GO:0006355 ISS:UniProtKB P regulation of transcription, DNA-templated
GO:0051591 IEP:RGD P response to cAMP
GO:0051384 IEP:RGD P response to glucocorticoid
GO:0006390 IEA:Ensembl P transcription from mitochondrial promoter

REACTOME Pathway Links

REACTOME Pathway ID Description
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953600 Mitochondrial biogenesis
5953601 Organelle biogenesis and maintenance
5954333 PPARA activates gene expression
5954222 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5953599 Transcriptional activation of mitochondrial biogenesis

Domain Information

InterPro Annotations

Accession Description
IPR012677 Nucleotide-binding alpha-beta plait domain
IPR000504 RNA recognition motif domain

UniProt Annotations

Entry Information

Gene Name
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Protein Entry
PRGC2_RAT
UniProt ID
Q811R2
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PGC1beta-1a; IsoId=Q811R2-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; Synonyms=PGC1beta-2a; IsoId=Q811R2-2; Sequence=VSP_019303;
Domain Contains 3 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors
Function Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta- oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner
Induction Induced by combination of forskolin and dexamethasone in primary hepatocytes.
Similarity Contains 1 RRM (RNA recognition motif) domain
Subcellular Location Nucleus .
Subunit Interacts with estrogen receptor alpha/ESR1. Interacts with Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with Estrogen-related receptor gamma/ESRRG and alpha/ESRRA. Interacts with PRDM16 (By similarity)
Tissue Specificity Ubiquitous with higher expression in heart, brown adipose tissue

Identical and Related Proteins

Unique RefSeq proteins for LMP013077 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
28570176 RefSeq NP_788264 990 peroxisome proliferator-activated receptor gamma coactivator 1-beta

Identical Sequences to LMP013077 proteins

Reference Database Accession Length Protein Name
GI:28570176 GenBank AAO40026.1 990 peroxisome proliferator-activated receptor gamma coactivator 1beta-2a [Rattus norvegicus]
GI:28570176 GenBank ABY15215.1 990 Sequence 10 from patent US 7306922

Related Sequences to LMP013077 proteins

Reference Database Accession Length Protein Name
GI:28570176 GenBank AAO40026.1 990 peroxisome proliferator-activated receptor gamma coactivator 1beta-2a [Rattus norvegicus]
GI:28570176 GenBank EDM14599.1 1010 peroxisome proliferative activated receptor, gamma, coactivator 1 beta, isoform CRA_b [Rattus norvegicus]
GI:28570176 GenBank ABY15215.1 990 Sequence 10 from patent US 7306922
GI:28570176 SwissProt Q811R2.2 1010 RecName: Full=Peroxisome proliferator-activated receptor gamma coactivator 1-beta; Short=PGC-1-beta; Short=PPAR-gamma coactivator 1-beta; Short=PPARGC-1-beta [Rattus norvegicus]