Gene/Proteome Database (LMPD)

LMPD ID
LMP013072
Gene ID
291437
Species
Rattus norvegicus (Rat)
Gene Name
lipase, endothelial
Gene Symbol
Lipg
Synonyms
lipase;
Alternate Names
endothelial lipase; EDL; lipase G; endothelial-derived lipase;
Chromosome
18
Map Location
18q12.3
EC Number
3.1.1.3

Proteins

endothelial lipase precursor
Refseq ID NP_001012759
Protein GI 60678260
UniProt ID Q8VBX1
mRNA ID NM_001012741
Length 493
MRDPVFLLGFWSLYCCFPAGSLTTLRPQGSLRDEHHKPTGVPVTITTKPSVTFNIRTSKDPEHEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQTREKEANVVVVDWLPLAHQLYIDAVSNTRVVGRRVAGMLNWLQEKGEFSLGDVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHIDIYPNGGDFQPGCGFNDVMGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDPNRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFRVYHYQLKVHMFSYKNSGDIQPDLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEYLGDLFKIRLTWEGVSSSWYNLWNEFRSYLSQPSSPSRELHIRRIRVKSGETQRKVAFCVQDPMKNSISPGQELWFYKCQNDCRVKN
sig_peptide: 1..23 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q8VBX1.2) calculated_mol_wt: 2624 peptide sequence: MRDPVFLLGFWSLYCCFPAGSLT mat_peptide: 24..493 product: Endothelial lipase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8VBX1.2) calculated_mol_wt: 53318 peptide sequence: TLRPQGSLRDEHHKPTGVPVTITTKPSVTFNIRTSKDPEHEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQTREKEANVVVVDWLPLAHQLYIDAVSNTRVVGRRVAGMLNWLQEKGEFSLGDVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHIDIYPNGGDFQPGCGFNDVMGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDPNRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFRVYHYQLKVHMFSYKNSGDIQPDLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEYLGDLFKIRLTWEGVSSSWYNLWNEFRSYLSQPSSPSRELHIRRIRVKSGETQRKVAFCVQDPMKNSISPGQELWFYKCQNDCRVKN

Gene Information

Entrez Gene ID
291437
Gene Name
lipase, endothelial
Gene Symbol
Lipg
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IDA:RGD C extracellular space
GO:0008201 IEA:UniProtKB-KW F heparin binding
GO:0004465 IEA:InterPro F lipoprotein lipase activity
GO:0008970 IEA:Ensembl F phosphatidylcholine 1-acylhydrolase activity
GO:0008283 IDA:RGD P cell proliferation
GO:0042632 IEA:Ensembl P cholesterol homeostasis
GO:0034375 IEA:Ensembl P high-density lipoprotein particle remodeling
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0055091 IEA:Ensembl P phospholipid homeostasis
GO:0032376 IEA:Ensembl P positive regulation of cholesterol transport
GO:0010983 IEA:Ensembl P positive regulation of high-density lipoprotein particle clearance
GO:0050746 IEA:Ensembl P regulation of lipoprotein metabolic process
GO:0007584 IEP:RGD P response to nutrient
GO:0043691 IEA:Ensembl P reverse cholesterol transport

KEGG Pathway Links

KEGG Pathway ID Description
M00098 Acylglycerol degradation
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
rno01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR013818 Lipase, N-terminal
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR002330 Lipoprotein lipase
IPR016272 Lipoprotein_lipase_LIPH
IPR001024 PLAT/LH2 domain
IPR000734 Triacylglycerol lipase family

UniProt Annotations

Entry Information

Gene Name
lipase, endothelial
Protein Entry
LIPE_RAT
UniProt ID
Q8VBX1
Species
Rat

Comments

Comment Type Description
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Function Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin (By similarity)
Miscellaneous It is termed endothelial lipase due to the fact that it is synthesized in endothelial cells, a characteristic that distinguishes it from other members of the family. However, this protein is also expressed in other cell types.
Similarity Belongs to the AB hydrolase superfamily. Lipase family
Similarity Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular Location Secreted .
Subunit Head to tail Homodimer. Interacts with apolipoprotein C-2 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP013072 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
60678260 RefSeq NP_001012759 493 endothelial lipase precursor

Identical Sequences to LMP013072 proteins

Reference Database Accession Length Protein Name
GI:60678260 GenBank AAX11354.1 493 endothelial lipase [Rattus norvegicus]
GI:60678260 GenBank EDL82874.1 493 rCG41727 [Rattus norvegicus]
GI:60678260 SwissProt Q8VBX1.2 493 RecName: Full=Endothelial lipase; AltName: Full=Endothelial-derived lipase; Short=EDL; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP013072 proteins

Reference Database Accession Length Protein Name
GI:60678260 GenBank AAX11354.1 493 endothelial lipase [Rattus norvegicus]
GI:60678260 GenBank EDL82874.1 493 rCG41727 [Rattus norvegicus]
GI:60678260 SwissProt Q8VBX1.2 493 RecName: Full=Endothelial lipase; AltName: Full=Endothelial-derived lipase; Short=EDL; Flags: Precursor [Rattus norvegicus]
GI:60678260 SwissProt Q9WVG5.3 500 RecName: Full=Endothelial lipase; AltName: Full=Endothelial cell-derived lipase; Short=EDL; Flags: Precursor [Mus musculus]