Gene/Proteome Database (LMPD)

LMPD ID
LMP013067
Gene ID
291211
Species
Rattus norvegicus (Rat)
Gene Name
geranylgeranyl diphosphate synthase 1
Gene Symbol
Ggps1
Synonyms
Crlf3; rGGPS1a; rGGPS1a1; rGGPS1a2; rGGPS1a3;
Alternate Names
geranylgeranyl pyrophosphate synthase; GGPPSase; GGPP synthase; GGPP synthetase; geranyltranstransferase; farnesyltranstransferase; dimethylallyltranstransferase; farnesyl diphosphate synthase; (2E,6E)-farnesyl diphosphate synthase; geranylgeranyl pyrophosphate synthetase;
Chromosome
17
Map Location
17q12.1
EC Number
2.5.1.-

Proteins

geranylgeranyl pyrophosphate synthase
Refseq ID NP_001007627
Protein GI 56090562
UniProt ID Q6F596
mRNA ID NM_001007626
Length 300
MEKTKEKAERILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDSSKLRRGFPVAHSIYGVPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDTYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLDTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVQYLEDVGSFEYTRYTLRELEAKAYKQIEACGGNPSLVALVKHLSKMFTEENE

Gene Information

Entrez Gene ID
291211
Gene Name
geranylgeranyl diphosphate synthase 1
Gene Symbol
Ggps1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0004161 IEA:UniProtKB-EC F dimethylallyltranstransferase activity
GO:0004311 ISS:UniProtKB F farnesyltranstransferase activity
GO:0004337 IEA:UniProtKB-EC F geranyltranstransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0045337 IEA:UniProtKB-UniPathway P farnesyl diphosphate biosynthetic process
GO:0033384 IEA:UniProtKB-UniPathway P geranyl diphosphate biosynthetic process
GO:0033386 IEA:UniProtKB-UniPathway P geranylgeranyl diphosphate biosynthetic process
GO:0006720 ISS:UniProtKB P isoprenoid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00900 Terpenoid backbone biosynthesis
rno00900 Terpenoid backbone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5954496 Activation of gene expression by SREBF (SREBP)
5953924 Cholesterol biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954497 Regulation of cholesterol biosynthesis by SREBP (SREBF)

Domain Information

InterPro Annotations

Accession Description
IPR008949 Isoprenoid synthase domain
IPR000092 Polyprenyl synthetase
IPR017446 Polyprenyl synthetase-related

UniProt Annotations

Entry Information

Gene Name
geranylgeranyl diphosphate synthase 1
Protein Entry
GGPPS_RAT
UniProt ID
Q6F596
Species
Rat

Comments

Comment Type Description
Catalytic Activity (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
Catalytic Activity Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Catalytic Activity Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Note=Binds 3 Mg(2+) ions per subunit. ;
Function Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
Pathway Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
Pathway Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
Pathway Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.
Similarity Belongs to the FPP/GGPP synthase family
Subcellular Location Cytoplasm .
Subunit Homohexamer; trimer of homodimers

Identical and Related Proteins

Unique RefSeq proteins for LMP013067 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
56090562 RefSeq NP_001007627 300 geranylgeranyl pyrophosphate synthase

Identical Sequences to LMP013067 proteins

Reference Database Accession Length Protein Name
GI:56090562 DBBJ BAD30053.1 300 geranylgeranyl diphosphate synthase1 [Rattus norvegicus]
GI:56090562 DBBJ BAD30054.1 300 geranylgeranyl diphosphate synthase1 [Rattus norvegicus]
GI:56090562 GenBank AAH90327.1 300 Geranylgeranyl diphosphate synthase 1 [Rattus norvegicus]
GI:56090562 SwissProt Q6F596.1 300 RecName: Full=Geranylgeranyl pyrophosphate synthase; Short=GGPP synthase; Short=GGPPSase; AltName: Full=(2E,6E)-farnesyl diphosphate synthase; AltName: Full=Dimethylallyltranstransferase; AltName: Full=Farnesyl diphosphate synthase; AltName: Full=Farnesyltranstransferase; AltName: Full=Geranylgeranyl diphosphate synthase; AltName: Full=Geranyltranstransferase [Rattus norvegicus]

Related Sequences to LMP013067 proteins

Reference Database Accession Length Protein Name
GI:56090562 DBBJ BAD30051.1 300 geranylgeranyl diphosphate synthase1 [Rattus norvegicus]
GI:56090562 DBBJ BAD30052.1 300 geranylgeranyl diphosphate synthase1 [Rattus norvegicus]
GI:56090562 DBBJ BAD30053.1 300 geranylgeranyl diphosphate synthase1 [Rattus norvegicus]
GI:56090562 SwissProt Q6F596.1 300 RecName: Full=Geranylgeranyl pyrophosphate synthase; Short=GGPP synthase; Short=GGPPSase; AltName: Full=(2E,6E)-farnesyl diphosphate synthase; AltName: Full=Dimethylallyltranstransferase; AltName: Full=Farnesyl diphosphate synthase; AltName: Full=Farnesyltranstransferase; AltName: Full=Geranylgeranyl diphosphate synthase; AltName: Full=Geranyltranstransferase [Rattus norvegicus]