Gene/Proteome Database (LMPD)

LMPD ID
LMP013066
Gene ID
291132
Species
Rattus norvegicus (Rat)
Gene Name
glycosylphosphatidylinositol specific phospholipase D1
Gene Symbol
Gpld1
Alternate Names
phosphatidylinositol-glycan-specific phospholipase D; GPI-PLD; PI-G PLD; GPI-specific phospholipase D; glycoprotein phospholipase D; glycosylphosphatidylinositol phospholipase D; glycosyl-phosphatidylinositol-specific phospholipase D;
Chromosome
17
Map Location
17p11
EC Number
3.1.4.50
Summary
an enzyme that is involved in insulin signaling pathways and is regulated by insulin [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Gpld1

Proteins

phosphatidylinositol-glycan-specific phospholipase D precursor
Refseq ID NP_001093982
Protein GI 213688382
UniProt ID Q8R2H5
mRNA ID NM_001100512
Length 843
MSVGRLWSGLLLLLLFFCSRSSSCGLSTHVEIGHRALQFLQLQDGRINYKELLLEHQDAYQAGTVFPDAFYPSICKQGKFHEVSESTHWTPFLNASIHYIRENYPLPWEKDTEKLVAFLFGVTSHMVADVSWHSLGIEQGFLRTMGAIDFYDSYSEAHSAGDFGGDVLSQFEFNFNYLSRRWYVPIQDLLRIYDNLYGRKVITKNVIVDCTYLQFLEMHGEMLAVSKLYSTYSTKSPFLVEQFQDYFLGGLDDMAFWSTNIYRLTSFMLENGTSDCNLPENPLFISCDGRKNHTLSSSKVQKNDFHRNLTMFISKDIRKNLNYTERGVFYSTGSWAPESVTFMYQTLERNLRMMFTGNSQTALKHVSSPSASYTLSVPYARLGWVMASADLNQDGHGDLVVGAPGYSHPGRFQIGRVYIIYGNDLGLPPIDLDLDKEAHGVLEGFQPSGRFGSALAVLDFNKDGLPDLAVGAPSVGSGQLTYNGSVYVYYGSQQGRLSSSPNITISCKDTYCNLGWALLAADADGDGQHDLVISSPFAPGGGKQRGIVAAFYSHPRRNDKESLTLDEADWKVNGEEDFSWFGYSLHGVTVANRSLLLIGSPTWKNISRMARSSHQKNQEKKSLGRVYGYFPPNRQREITISGDKAMGKLGTSLSSGYVRVNGTLTQVLLVGAPTHDDVSKMAFLTMTLHQGGATRMYELAPEKTQPALLSTFSGDRRFSRFGSVLHLTDLDDDGLDEIIMAAPLRITDVTSGLLGGEDGRVYIYNGMHTTLGDVTGKCKSWMTPCPEEKAQYVLISPEASSRFGSSLVSVRSKERNQVVVAAGRSSWGARLSGALHVYSFSSD
sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2573 peptide sequence: MSVGRLWSGLLLLLLFFCSRSSS mat_peptide: 24..843 product: Phosphatidylinositol-glycan-specific phospholipase D experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8R2H5.1) calculated_mol_wt: 91112 peptide sequence: CGLSTHVEIGHRALQFLQLQDGRINYKELLLEHQDAYQAGTVFPDAFYPSICKQGKFHEVSESTHWTPFLNASIHYIRENYPLPWEKDTEKLVAFLFGVTSHMVADVSWHSLGIEQGFLRTMGAIDFYDSYSEAHSAGDFGGDVLSQFEFNFNYLSRRWYVPIQDLLRIYDNLYGRKVITKNVIVDCTYLQFLEMHGEMLAVSKLYSTYSTKSPFLVEQFQDYFLGGLDDMAFWSTNIYRLTSFMLENGTSDCNLPENPLFISCDGRKNHTLSSSKVQKNDFHRNLTMFISKDIRKNLNYTERGVFYSTGSWAPESVTFMYQTLERNLRMMFTGNSQTALKHVSSPSASYTLSVPYARLGWVMASADLNQDGHGDLVVGAPGYSHPGRFQIGRVYIIYGNDLGLPPIDLDLDKEAHGVLEGFQPSGRFGSALAVLDFNKDGLPDLAVGAPSVGSGQLTYNGSVYVYYGSQQGRLSSSPNITISCKDTYCNLGWALLAADADGDGQHDLVISSPFAPGGGKQRGIVAAFYSHPRRNDKESLTLDEADWKVNGEEDFSWFGYSLHGVTVANRSLLLIGSPTWKNISRMARSSHQKNQEKKSLGRVYGYFPPNRQREITISGDKAMGKLGTSLSSGYVRVNGTLTQVLLVGAPTHDDVSKMAFLTMTLHQGGATRMYELAPEKTQPALLSTFSGDRRFSRFGSVLHLTDLDDDGLDEIIMAAPLRITDVTSGLLGGEDGRVYIYNGMHTTLGDVTGKCKSWMTPCPEEKAQYVLISPEASSRFGSSLVSVRSKERNQVVVAAGRSSWGARLSGALHVYSFSSD

Gene Information

Entrez Gene ID
291132
Gene Name
glycosylphosphatidylinositol specific phospholipase D1
Gene Symbol
Gpld1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0005615 IDA:UniProtKB C extracellular space
GO:0034364 IEA:UniProtKB-KW C high-density lipoprotein particle
GO:0043231 ISS:UniProtKB C intracellular membrane-bounded organelle
GO:0005578 ISS:UniProtKB C proteinaceous extracellular matrix
GO:0004621 IDA:UniProtKB F glycosylphosphatidylinositol phospholipase D activity
GO:0017080 ISS:UniProtKB F sodium channel regulator activity
GO:0006507 ISS:UniProtKB P GPI anchor release
GO:0002042 ISS:UniProtKB P cell migration involved in sprouting angiogenesis
GO:0071277 IDA:UniProtKB P cellular response to calcium ion
GO:0071397 ISS:UniProtKB P cellular response to cholesterol
GO:0035690 ISS:UniProtKB P cellular response to drug
GO:0071241 IDA:UniProtKB P cellular response to inorganic substance
GO:0032869 ISS:UniProtKB P cellular response to insulin stimulus
GO:0071282 IDA:UniProtKB P cellular response to iron(II) ion
GO:0071467 ISS:UniProtKB P cellular response to pH
GO:0071401 ISS:UniProtKB P cellular response to triglyceride
GO:0002062 ISS:UniProtKB P chondrocyte differentiation
GO:0002430 ISS:UniProtKB P complement receptor mediated signaling pathway
GO:0008286 ISS:UniProtKB P insulin receptor signaling pathway
GO:0008285 ISS:UniProtKB P negative regulation of cell proliferation
GO:0010897 ISS:UniProtKB P negative regulation of triglyceride catabolic process
GO:0001503 ISS:UniProtKB P ossification
GO:0046470 ISS:UniProtKB P phosphatidylcholine metabolic process
GO:0010694 ISS:UniProtKB P positive regulation of alkaline phosphatase activity
GO:0043065 ISS:UniProtKB P positive regulation of apoptotic process
GO:0045919 ISS:UniProtKB P positive regulation of cytolysis
GO:0010595 ISS:UniProtKB P positive regulation of endothelial cell migration
GO:0010907 ISS:UniProtKB P positive regulation of glucose metabolic process
GO:0010983 ISS:UniProtKB P positive regulation of high-density lipoprotein particle clearance
GO:0035774 ISS:UniProtKB P positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0051044 ISS:UniProtKB P positive regulation of membrane protein ectodomain proteolysis
GO:0051047 ISS:UniProtKB P positive regulation of secretion
GO:0010867 ISS:UniProtKB P positive regulation of triglyceride biosynthetic process
GO:1900076 ISS:UniProtKB P regulation of cellular response to insulin stimulus
GO:0009749 ISS:UniProtKB P response to glucose
GO:0070633 ISS:UniProtKB P transepithelial transport

KEGG Pathway Links

KEGG Pathway ID Description
ko00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
rno00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR013517 FG-GAP repeat
IPR001028 Glycoprotein phospholipase D
IPR013519 Integrin alpha beta-propellor
IPR029002 Phospholipase C/D

UniProt Annotations

Entry Information

Gene Name
glycosylphosphatidylinositol specific phospholipase D1
Protein Entry
PHLD_RAT
UniProt ID
Q8R2H5
Species
Rat

Comments

Comment Type Description
Catalytic Activity 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D- myo-inositol + H(2)O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + phosphatidate.
Function This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.
Ptm Glycosylated
Similarity Belongs to the GPLD1 family
Similarity Contains 7 FG-GAP repeats
Subcellular Location Secreted. Note=Associated with the High- Density Lipoproteins (HDL)
Subunit Monomer

Identical and Related Proteins

Unique RefSeq proteins for LMP013066 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
213688382 RefSeq NP_001093982 843 phosphatidylinositol-glycan-specific phospholipase D precursor

Identical Sequences to LMP013066 proteins

Reference Database Accession Length Protein Name
GI:213688382 RefSeq XP_008769852.1 843 PREDICTED: phosphatidylinositol-glycan-specific phospholipase D isoform X1 [Rattus norvegicus]
GI:213688382 RefSeq XP_008769853.1 843 PREDICTED: phosphatidylinositol-glycan-specific phospholipase D isoform X1 [Rattus norvegicus]
GI:213688382 RefSeq XP_008769854.1 843 PREDICTED: phosphatidylinositol-glycan-specific phospholipase D isoform X1 [Rattus norvegicus]
GI:213688382 RefSeq XP_008769856.1 843 PREDICTED: phosphatidylinositol-glycan-specific phospholipase D isoform X1 [Rattus norvegicus]

Related Sequences to LMP013066 proteins

Reference Database Accession Length Protein Name
GI:213688382 RefSeq XP_008769850.1 843 PREDICTED: phosphatidylinositol-glycan-specific phospholipase D isoform X1 [Rattus norvegicus]
GI:213688382 RefSeq XP_008769851.1 843 PREDICTED: phosphatidylinositol-glycan-specific phospholipase D isoform X2 [Rattus norvegicus]
GI:213688382 RefSeq XP_008769852.1 843 PREDICTED: phosphatidylinositol-glycan-specific phospholipase D isoform X1 [Rattus norvegicus]
GI:213688382 RefSeq XP_008769853.1 843 PREDICTED: phosphatidylinositol-glycan-specific phospholipase D isoform X1 [Rattus norvegicus]