Gene/Proteome Database (LMPD)

LMPD ID
LMP013055
Gene ID
290567
Species
Rattus norvegicus (Rat)
Gene Name
choline O-acetyltransferase
Gene Symbol
Chat
Alternate Names
choline O-acetyltransferase; CHOACTase; choline acetylase; choline acetyltransferase;
Chromosome
16
Map Location
16p16

Proteins

choline O-acetyltransferase
Refseq ID NP_001164064
Protein GI 282154809
mRNA ID NM_001170593
Length 644
MPILEKAPQKMPVKASSWEELDLPKLPVPPLQQTLATYLQCMQHLVPEEQFRKSQAIVKRFGAPGGLGETLQEKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFQDTNDQLRFAACLISGVLSYKTLLDSHSLPTDWAKGQLSGQPLCMKQYYRLFSSYRLPGHTQDTLVAQKSSIMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLPPIGLLTSDGRSEWAKARTVLLKDSTNRDSLDMIERCICLVCLDGPGTGELSDTHRALQLLHGGGCSLNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMMTSNKKLVRADSVSELPAPRRLRWKCSPETQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKYSPDGFIQVALQLAYYRLYQRLVPTYESASIRRFQEGRVDNIRSATPEALAFVQAMTDHKAAMPASEKLQLLQTAMQAQTEYTVMAITGMAIDNHLLALRELARDLCKEPPEMFMDETYLMSNRFVLSTSQVPTTMEMFCCYGPVVPNGYGACYNPQPEAITFCISSFHSCKETSSVEFAEAVGASLVDMRDLCSSRQPADSKPPAPKEKARGPTKPSNLDSSH

Gene Information

Entrez Gene ID
290567
Gene Name
choline O-acetyltransferase
Gene Symbol
Chat
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043005 IDA:RGD C neuron projection
GO:0004102 IDA:RGD F choline O-acetyltransferase activity
GO:0033265 IDA:RGD F choline binding
GO:0008292 IDA:RGD P acetylcholine biosynthetic process
GO:0001547 IEP:RGD P antral ovarian follicle growth
GO:0007613 IMP:RGD P memory
GO:0042136 TAS:RGD P neurotransmitter biosynthetic process
GO:0042493 IEP:RGD P response to drug
GO:0045471 IEP:RGD P response to ethanol
GO:0001666 IEP:RGD P response to hypoxia
GO:0007584 IEP:RGD P response to nutrient

KEGG Pathway Links

KEGG Pathway ID Description
rno04725 Cholinergic synapse
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR000542 Acyltransferase ChoActase/COT/CPT

UniProt Annotations

Entry Information

Gene Name
choline O-acetyltransferase
Species
Rat

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + choline = CoA + O-acetylcholine.
Function Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Similarity Belongs to the carnitine/choline acetyltransferase family. {ECO:0000305}.
Subunit Monomer. {ECO:0000269|PubMed:15131697, ECO:0000269|PubMed:15477102}.

Identical and Related Proteins

Unique RefSeq proteins for LMP013055 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
282154809 RefSeq NP_001164064 644 choline O-acetyltransferase

Identical Sequences to LMP013055 proteins

Reference Database Accession Length Protein Name
GI:282154809 PDB 1Q6X 644 Chain A, Crystal Structure Of Rat Choline Acetyltransferase
GI:282154809 PDB 1Q6X 644 Chain B, Crystal Structure Of Rat Choline Acetyltransferase

Related Sequences to LMP013055 proteins

Reference Database Accession Length Protein Name
GI:282154809 PDB 1Q6X 644 Chain A, Crystal Structure Of Rat Choline Acetyltransferase
GI:282154809 PDB 1Q6X 644 Chain B, Crystal Structure Of Rat Choline Acetyltransferase
GI:282154809 PDB 1T1U 639 Chain A, Structural Insights And Functional Implications Of Choline Acetyltransferase
GI:282154809 PRF - 640 choline acetyltransferase [Rattus norvegicus]