Gene/Proteome Database (LMPD)

LMPD ID
LMP013050
Gene ID
290277
Species
Rattus norvegicus (Rat)
Gene Name
crystallin, lambda 1
Gene Symbol
Cryl1
Alternate Names
lambda-crystallin homolog; gul3DH; crystallin, lamda 1; L-gulonate 3-dehydrogenase;
Chromosome
15
Map Location
15p12
EC Number
1.1.1.45
Summary
human homolog is a putative enzyme-crystallin that is downregulated in cancer tissues [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Cryl1

Proteins

lambda-crystallin homolog
Refseq ID NP_786933
Protein GI 28461157
UniProt ID Q811X6
mRNA ID NM_175757
Length 319
MASPAAGGVVIIGSGLIGRSWAMLFASGGFKVKLYDIEQQQITNALESIRKEMKSLEQSGSLKGSLGAEQQLSLISGCGNLAEAVEGAMHIQECVPENLELKKKIFAQLDRIVDDQVILSSSSSCLLPSKLFTGLAHVKQCIVAHPVNPPYYVPLVELVPHPETAPATMDRTYALMKKIRQTPVRVLKEIDGFVLNRLQYAIISEAWRLVEEGIVSPNDLDLVMSDGLGMRYAFIGPLETMHLNAEGMVSYCDRYSEGMKRVLKTFGPVPEFSGDTVEKVNQDMCMKVPDDPEHLAARRHWRDDCLMQLSKLKHQMQPQ

Gene Information

Entrez Gene ID
290277
Gene Name
crystallin, lambda 1
Gene Symbol
Cryl1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 ISS:UniProtKB C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0003857 IEA:InterPro F 3-hydroxyacyl-CoA dehydrogenase activity
GO:0050104 ISS:UniProtKB F L-gulonate 3-dehydrogenase activity
GO:0070403 ISS:UniProtKB F NAD+ binding
GO:0006631 IEA:InterPro P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
M00014 Glucuronate pathway (uronate pathway)
rno01100 Metabolic pathways
ko00040 Pentose and glucuronate interconversions
rno00040 Pentose and glucuronate interconversions

Domain Information

InterPro Annotations

Accession Description
IPR022694 3-hydroxyacyl-CoA dehydrogenase
IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal
IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding
IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved site
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR013328 Dehydrogenase, multihelical
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
crystallin, lambda 1
Protein Entry
CRYL1_RAT
UniProt ID
Q811X6
Species
Rat

Comments

Comment Type Description
Catalytic Activity L-gulonate + NAD(+) = 3-dehydro-L-gulonate + NADH.
Similarity Belongs to the 3-hydroxyacyl-CoA dehydrogenase family
Subcellular Location Cytoplasm .
Subunit Homodimer

Identical and Related Proteins

Unique RefSeq proteins for LMP013050 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
28461157 RefSeq NP_786933 319 lambda-crystallin homolog

Identical Sequences to LMP013050 proteins

Reference Database Accession Length Protein Name
GI:28461157 GenBank AAK72608.1 319 CRY [Rattus norvegicus]
GI:28461157 GenBank AAH78685.1 319 Crystallin, lambda 1 [Rattus norvegicus]
GI:28461157 SwissProt Q811X6.3 319 RecName: Full=Lambda-crystallin homolog; AltName: Full=L-gulonate 3-dehydrogenase; Short=Gul3DH [Rattus norvegicus]

Related Sequences to LMP013050 proteins

Reference Database Accession Length Protein Name
GI:28461157 GenBank AAK72608.1 319 CRY [Rattus norvegicus]
GI:28461157 GenBank AAH78685.1 319 Crystallin, lambda 1 [Rattus norvegicus]
GI:28461157 RefSeq XP_006988491.1 319 PREDICTED: lambda-crystallin homolog [Peromyscus maniculatus bairdii]
GI:28461157 SwissProt Q811X6.3 319 RecName: Full=Lambda-crystallin homolog; AltName: Full=L-gulonate 3-dehydrogenase; Short=Gul3DH [Rattus norvegicus]