Gene/Proteome Database (LMPD)

LMPD ID
LMP013016
Gene ID
287745
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase C, delta 3
Gene Symbol
Plcd3
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3;
Chromosome
10
Map Location
10q32.1
EC Number
3.1.4.11

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
Refseq ID NP_001099315
Protein GI 164518912
UniProt ID D4A978
mRNA ID NM_001105845
Length 788
MLCGGWRRSRRSPEEPRVSAQVAAPLAFLPSPASSDSSTKRPGLRALKKMGLTEDEDVQAMLRGSKLLKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAASQHIFFVQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLAKLRARLDAMSQRERLDHAHTWIHSYLHRADSDQDSKMSFKEIKSLLRMVNVDMNDMYAYRLFKECDHSNNERLEGAEIEAFLRRLLKRPELEEIFRRYSGEDRVLSASELLEFLEDQGEDGATLACAQKLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALNVAHTCVFQDMGQPLAHYFISSSHNTYLTDSQIGGTSSTEAYIRAFTQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVIQAVRDHAFTLSPYPVILSLENHCGLEQQIVMARHLRNILGDMLVTQALDSQNPEELPSPEQLKCRVLVKGKKLPAARNEDGRILSDREDEDEDEEEAEEALETAEQRKRAKQISPELSALVVYCCATRLRTLEPSPGPPQPCKIGSLSERKARKFTREAGTSFVRHNTQQLTRVYPLGLRMTSANYNPQEMWNSGCQLVALNFQTPGYEMDLNTGRFLINGQCGYVLKPAYLRQLNTTFDPECPGPPRTTLTVQVLTAQQLPKLNVEKPNSIVDPLVRVEIYGVPEDCAHKETDYVLNNGFNPCWEQTLQFQLRAPELVLVRFVVEDYDTTSPNDFVGQFTLPLNSLKQGYRHIHLLSKDGASLSPATLFVHIRIENS

Gene Information

Entrez Gene ID
287745
Gene Name
phospholipase C, delta 3
Gene Symbol
Plcd3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:RGD C cytosol
GO:0016020 IDA:RGD C membrane
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0001525 IEA:Ensembl P angiogenesis
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0060716 IEA:Ensembl P labyrinthine layer blood vessel development
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0042127 IEA:Ensembl P regulation of cell proliferation

KEGG Pathway Links

KEGG Pathway ID Description
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
rno04919 Thyroid hormone signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954515 Inositol phosphate metabolism
5953250 Metabolism
5954514 Synthesis of IP3 and IP4 in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR028406 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, delta 3
Protein Entry
D4A978_RAT
UniProt ID
D4A978
Species
Rat

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Caution The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data
Similarity Contains 1 C2 domain
Similarity Contains 1 PH domain
Similarity Contains 1 PI-PLC X-box domain
Similarity Contains 1 PI-PLC Y-box domain
Similarity Contains C2 domain
Similarity Contains Cdomain
Similarity Contains PH domain
Similarity Contains PI-PLC X-box domain
Similarity Contains PI-PLC Y-box domain

Identical and Related Proteins

Unique RefSeq proteins for LMP013016 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
164518912 RefSeq NP_001099315 788 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

Identical Sequences to LMP013016 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP013016 proteins

Reference Database Accession Length Protein Name
GI:164518912 EMBL CBU87815.1 785 unnamed protein product [Mus musculus]
GI:164518912 EMBL CBU96762.1 785 unnamed protein product [Mus musculus]
GI:164518912 GenBank AAH31392.1 785 Phospholipase C, delta 3 [Mus musculus]
GI:164518912 RefSeq XP_006247556.1 785 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [Rattus norvegicus]