Gene/Proteome Database (LMPD)

LMPD ID
LMP012990
Gene ID
266607
Species
Rattus norvegicus (Rat)
Gene Name
free fatty acid receptor 1
Gene Symbol
Ffar1
Synonyms
Gpr40;
Alternate Names
free fatty acid receptor 1; G protein-coupled receptor 40; G-protein coupled receptor 40;
Chromosome
1
Map Location
1q21
Summary
orphan G-protein coupled receptor family that is activated by medium and long chain fatty acids; may mediate physiological changes in pancreatic islets [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ffar1

Proteins

free fatty acid receptor 1
Refseq ID NP_695216
Protein GI 23463291
UniProt ID Q8K3T4
mRNA ID NM_153304
Length 300
MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLACSDLLLAITLPLKAVEALASGVWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPCYSWGVCVAIWALVLCHLGLALGLEAPRGWVDNTTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVHSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLEGSWRKLGLITGAWSVVLNPLVTGYLGTGPGQGTICVTRTPRGTIQK

Gene Information

Entrez Gene ID
266607
Gene Name
free fatty acid receptor 1
Gene Symbol
Ffar1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004930 IEA:UniProtKB-KW F G-protein coupled receptor activity
GO:0005504 IDA:RGD F fatty acid binding
GO:0007186 IDA:RGD P G-protein coupled receptor signaling pathway
GO:0010524 IMP:RGD P positive regulation of calcium ion transport into cytosol
GO:0032024 IMP:RGD P positive regulation of insulin secretion

KEGG Pathway Links

KEGG Pathway ID Description
rno04911 Insulin secretion

Domain Information

InterPro Annotations

Accession Description
IPR013312 G protein-coupled receptor 40-related receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR013313 GPR40 receptor fatty acid

UniProt Annotations

Entry Information

Gene Name
free fatty acid receptor 1
Protein Entry
FFAR1_RAT
UniProt ID
Q8K3T4
Species
Rat

Comments

Comment Type Description
Function G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)- mediated pathway. {ECO:0000250|UniProtKB:O14842, ECO:0000250|UniProtKB:Q76JU9}.
Similarity Belongs to the G-protein coupled receptor 1 family
Subcellular Location Cell membrane ; Multi-pass membrane protein .
Tissue Specificity Expressed abundantly in pancreatic beta cells

Identical and Related Proteins

Unique RefSeq proteins for LMP012990 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
23463291 RefSeq NP_695216 300 free fatty acid receptor 1

Identical Sequences to LMP012990 proteins

Reference Database Accession Length Protein Name
GI:23463291 DBBJ BAC82554.1 300 GPR40 [Rattus norvegicus]
GI:23463291 GenBank AEI20901.1 300 Sequence 3 from patent US 7960369
GI:23463291 GenBank AFQ84288.1 300 Sequence 6 from patent US 8252521
GI:23463291 SwissProt Q8K3T4.1 300 RecName: Full=Free fatty acid receptor 1; AltName: Full=G-protein coupled receptor 40 [Rattus norvegicus]

Related Sequences to LMP012990 proteins

Reference Database Accession Length Protein Name
GI:23463291 DBBJ BAC82554.1 300 GPR40 [Rattus norvegicus]
GI:23463291 GenBank AEI20901.1 300 Sequence 3 from patent US 7960369
GI:23463291 GenBank AFQ84288.1 300 Sequence 6 from patent US 8252521
GI:23463291 SwissProt Q8K3T4.1 300 RecName: Full=Free fatty acid receptor 1; AltName: Full=G-protein coupled receptor 40 [Rattus norvegicus]