Gene/Proteome Database (LMPD)

LMPD ID
LMP012987
Gene ID
260321
Species
Rattus norvegicus (Rat)
Gene Name
FK506 binding protein 4
Gene Symbol
Fkbp4
Synonyms
p59; FKBP-4; FKBP-52;
Alternate Names
peptidyl-prolyl cis-trans isomerase FKBP4; HBI; FKBP59; rotamase; 52 kDa FKBP; PPIase FKBP4; FKBP52 protein; 59 kDa immunophilin; immunophilin FKBP52; FK506-binding protein 4; FK506 binding protein 52; HSP-binding immunophilin; 52 kDa FK506-binding protein;
Chromosome
4
Map Location
4q42
EC Number
5.2.1.8

Proteins

peptidyl-prolyl cis-trans isomerase FKBP4
Refseq ID NP_001178792
Protein GI 300797999
UniProt ID Q9QVC8
mRNA ID NM_001191863
Length 458
MTAEEMKVAENGAQSAPLPLEGVDISPKQDEGVLKVIKREGTGTETAMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEDEDGGIIRRIRTRGEGYARPNDGAMVEVALEGYYNDRLFDQRELCFEVGEGESLDLPCGLEEAIQRMEKGEHSIVYLKPSYAFGSVGKERFQIPPHAELRYEVHLKSFEKAKASWEMNSEEKLEQSNIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSGEEMQKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHKAKTEVAAGDHPTDAEMKGEPNNVAGNQAQVKTEA

Gene Information

Entrez Gene ID
260321
Gene Name
FK506 binding protein 4
Gene Symbol
Fkbp4
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0044295 IDA:UniProtKB C axonal growth cone
GO:0005829 IDA:UniProtKB C cytosol
GO:0005789 IBA:RefGenome C endoplasmic reticulum membrane
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005874 IEA:UniProtKB-KW C microtubule
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0043005 IDA:RGD C neuron projection
GO:0043025 IDA:RGD C neuronal cell body
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0048471 IDA:RGD C perinuclear region of cytoplasm
GO:0043234 IDA:RGD C protein complex
GO:0005524 IEA:Ensembl F ATP binding
GO:0005528 IBA:RefGenome F FK506 binding
GO:0005525 IEA:Ensembl F GTP binding
GO:0032767 IPI:RGD F copper-dependent protein binding
GO:0003755 ISS:UniProtKB F peptidyl-prolyl cis-trans isomerase activity
GO:0044822 IEA:Ensembl F poly(A) RNA binding
GO:0048156 IPI:UniProtKB F tau protein binding
GO:0030521 IEA:Ensembl P androgen receptor signaling pathway
GO:0061077 ISS:UniProtKB P chaperone-mediated protein folding
GO:0006825 IMP:RGD P copper ion transport
GO:0007566 IEA:Ensembl P embryo implantation
GO:0046661 IEA:Ensembl P male sex differentiation
GO:0031115 IMP:RGD P negative regulation of microtubule polymerization
GO:0031111 ISS:UniProtKB P negative regulation of microtubule polymerization or depolymerization
GO:0010977 ISS:UniProtKB P negative regulation of neuron projection development
GO:0030850 IEA:Ensembl P prostate gland development
GO:0031503 IEA:Ensembl P protein complex localization
GO:0000413 IBA:RefGenome P protein peptidyl-prolyl isomerization
GO:0006463 IEA:Ensembl P steroid hormone receptor complex assembly

KEGG Pathway Links

KEGG Pathway ID Description
ko04915 Estrogen signaling pathway
rno04915 Estrogen signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954623 Attenuation phase
5954621 Cellular response to heat stress
5953238 Cellular responses to stress
5954624 HSF1-dependent transactivation

Domain Information

InterPro Annotations

Accession Description
IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
IPR001440 Tetratricopeptide TPR1
IPR019734 Tetratricopeptide repeat
IPR013026 Tetratricopeptide repeat-containing domain
IPR011990 Tetratricopeptide-like helical domain

UniProt Annotations

Entry Information

Gene Name
FK506 binding protein 4
Protein Entry
FKBP4_RAT
UniProt ID
Q9QVC8
Species
Rat

Comments

Comment Type Description
Catalytic Activity Peptidylproline (omega=180) = peptidylproline (omega=0).
Domain The C-terminal region (AA 375-458) is required to prevent tubulin polymerization.
Domain The PPIase activity is mainly due to the fisrt PPIase FKBP-type domain (1-138 AA)
Domain The TPR repeats mediate mitochondrial localization
Domain The chaperone activity resides in the C-terminal region, mainly between amino acids 264 and 400
Enzyme Regulation Inhibited by FK506
Function Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) (By similarity). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. May have a protective role against oxidative stress in mitochondria (By similarity). Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. The PPIase activity controls neuronal growth cones via regulation of TRPC1 channel opening. {ECO:0000250, ECO:0000269|PubMed:17435176, ECO:0000269|PubMed:20133804}.
Ptm Phosphorylation by CK2 results in loss of HSP90 binding activity.
Similarity Contains 2 PPIase FKBP-type domains
Similarity Contains 3 TPR repeats. {ECO:0000255|PROSITE- ProRule:PRU00339}.
Subcellular Location Cytoplasm, cytosol . Mitochondrion {ECO:0000250}. Nucleus . Cytoplasm, cytoskeleton . Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (By similarity). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons
Subunit Homodimer (By similarity). Associates (via TPR domains) with HSP90 and HSP70 in unactivated steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha- hydroxylase (PHYH) (By similarity). Interacts with NR3C1 and dynein. Interacts with HSF1 in the HSP90 complex (By similarity). Associates with tubulin (By similarity). Interacts with MAPT/TAU; the interaction is enhanced for phosphorylated MAPT/TAU. Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent (By similarity). Interaction with S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction (By similarity)
Tissue Specificity Widely detected in the brain (at protein level)
Web Resource Name=Protein Spotlight; Note=A mind astray - Issue 118 of June 2010; URL="http://web.expasy.org/spotlight/back_issues/118";

Identical and Related Proteins

Unique RefSeq proteins for LMP012987 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
300797999 RefSeq NP_001178792 458 peptidyl-prolyl cis-trans isomerase FKBP4

Identical Sequences to LMP012987 proteins

Reference Database Accession Length Protein Name
GI:300797999 GenBank EDM01775.1 458 FK506 binding protein 4 [Rattus norvegicus]
GI:300797999 SwissProt Q9QVC8.3 458 RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP4; Short=PPIase FKBP4; AltName: Full=52 kDa FK506-binding protein; Short=52 kDa FKBP; Short=FKBP-52; AltName: Full=59 kDa immunophilin; Short=p59; AltName: Full=FK506-binding protein 4; Short=FKBP-4; AltName: Full=FKBP59; AltName: Full=HSP-binding immunophilin; Short=HBI; AltName: Full=Immunophilin FKBP52; AltName: Full=Rotamase; Contains: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed [Rattus norvegicus]

Related Sequences to LMP012987 proteins

Reference Database Accession Length Protein Name
GI:300797999 GenBank EDM01775.1 458 FK506 binding protein 4 [Rattus norvegicus]
GI:300797999 RefSeq XP_007644424.1 458 PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP4 isoform X1 [Cricetulus griseus]
GI:300797999 SwissProt P30416.5 458 RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP4; Short=PPIase FKBP4; AltName: Full=52 kDa FK506-binding protein; Short=52 kDa FKBP; Short=FKBP-52; AltName: Full=59 kDa immunophilin; Short=p59; AltName: Full=FK506-binding protein 4; Short=FKBP-4; AltName: Full=FKBP59; AltName: Full=HSP-binding immunophilin; Short=HBI; AltName: Full=Immunophilin FKBP52; AltName: Full=Rotamase; Contains: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed [Mus musculus]
GI:300797999 SwissProt Q9QVC8.3 458 RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP4; Short=PPIase FKBP4; AltName: Full=52 kDa FK506-binding protein; Short=52 kDa FKBP; Short=FKBP-52; AltName: Full=59 kDa immunophilin; Short=p59; AltName: Full=FK506-binding protein 4; Short=FKBP-4; AltName: Full=FKBP59; AltName: Full=HSP-binding immunophilin; Short=HBI; AltName: Full=Immunophilin FKBP52; AltName: Full=Rotamase; Contains: RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed [Rattus norvegicus]