Gene/Proteome Database (LMPD)

LMPD ID
LMP012975
Gene ID
246298
Species
Rattus norvegicus (Rat)
Gene Name
retinol saturase (all trans retinol 13,14 reductase)
Gene Symbol
Retsat
Synonyms
Rmt7;
Alternate Names
all-trans-retinol 13,14-reductase; RMT-7; hypothetical protein RMT-7; all-trans-13,14-dihydroretinol saturase; PPAR-alpha-regulated and starvation-induced gene protein;
Chromosome
4
Map Location
4q33
EC Number
1.3.99.23
Summary
mRNA displays differential expression in methylnitrosourea-induced mammary carcinomas [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Retsat

Proteins

all-trans-retinol 13,14-reductase precursor
Refseq ID NP_659552
Protein GI 21489985
UniProt ID Q8VHE9
mRNA ID NM_145084
Length 609
MWITALLLVVLLLVVVHRVYVGLFTGSSPNPFAEDVKRPPEPLVTDKEARKKVLKQAFSVSRVPEKLDAVVIGSGIGGLASAAVLAKAGKRVLVLEQHTKAGGCCHTFGENGLEFDTGIHYIGRMREGNIGRFILDQITEGQLDWAPMASPFDLMILEGPNGRKEFPMYSGRKEYIQGLKEKFPKEEAVIDKYMELVKVVAHGVSHAILLKFLPLPLTQLLNKFGLLTRFSPFCRASTQSLAEVLKQLGASPELQAVLSYILPTYGVTPSHTTFSLHALLVDHYIQGAYYPRRGSSEIAFHTIPLIQRAGGAVLTRATVQSVLLDSAGRACGVSVKKGQELVNIYCPVVISNAGMFNTYQHLLPESVRYLPDVKKQLTMVKPGLSMLSIFICLKGTKEELKLQSTNYYVYFDTDMDKAMECYVSMPKEKAPEHIPLLFIPFPSSKDPTWEDRFPDRSTMTVLVPTAFEWFEEWQEEPKGKRGVDYETLKNTFREASMSVIMKLFPQLEGKVESVTGGSPLTNQYYLAAHRGATYGADHDLARLHPHAMASLRAQTPIPNLYLTGQDIFTCGLMGALQGALLCSSAILKRNLYSDLQALGSKVRAQKKKK
sig_peptide: 1..21 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q8VHE9.1) calculated_mol_wt: 2450 peptide sequence: MWITALLLVVLLLVVVHRVYV mat_peptide: 22..609 product: All-trans-retinol 13,14-reductase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8VHE9.1) calculated_mol_wt: 65099 peptide sequence: GLFTGSSPNPFAEDVKRPPEPLVTDKEARKKVLKQAFSVSRVPEKLDAVVIGSGIGGLASAAVLAKAGKRVLVLEQHTKAGGCCHTFGENGLEFDTGIHYIGRMREGNIGRFILDQITEGQLDWAPMASPFDLMILEGPNGRKEFPMYSGRKEYIQGLKEKFPKEEAVIDKYMELVKVVAHGVSHAILLKFLPLPLTQLLNKFGLLTRFSPFCRASTQSLAEVLKQLGASPELQAVLSYILPTYGVTPSHTTFSLHALLVDHYIQGAYYPRRGSSEIAFHTIPLIQRAGGAVLTRATVQSVLLDSAGRACGVSVKKGQELVNIYCPVVISNAGMFNTYQHLLPESVRYLPDVKKQLTMVKPGLSMLSIFICLKGTKEELKLQSTNYYVYFDTDMDKAMECYVSMPKEKAPEHIPLLFIPFPSSKDPTWEDRFPDRSTMTVLVPTAFEWFEEWQEEPKGKRGVDYETLKNTFREASMSVIMKLFPQLEGKVESVTGGSPLTNQYYLAAHRGATYGADHDLARLHPHAMASLRAQTPIPNLYLTGQDIFTCGLMGALQGALLCSSAILKRNLYSDLQALGSKVRAQKKKK

Gene Information

Entrez Gene ID
246298
Gene Name
retinol saturase (all trans retinol 13,14 reductase)
Gene Symbol
Retsat
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 ISS:HGNC C endoplasmic reticulum membrane
GO:0031965 ISS:HGNC C nuclear membrane
GO:0005640 ISS:HGNC C nuclear outer membrane
GO:0051786 ISS:HGNC F all-trans-retinol 13,14-reductase activity
GO:0016491 ISS:HGNC F oxidoreductase activity
GO:0055114 ISS:HGNC P oxidation-reduction process
GO:0042572 ISS:HGNC P retinol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00830 Retinol metabolism
rno00830 Retinol metabolism

Domain Information

InterPro Annotations

Accession Description

UniProt Annotations

Entry Information

Gene Name
retinol saturase (all trans retinol 13,14 reductase)
Protein Entry
RETST_RAT
UniProt ID
Q8VHE9
Species
Rat

Comments

Comment Type Description
Catalytic Activity All-trans-13,14-dihydroretinol + acceptor = all-trans-retinol + reduced acceptor.
Cofactor Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence= ; Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence= ; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence= ;
Cofactor Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250}; Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence={ECO:0000250}; Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Function Retinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity)
Function Retinol saturase carrying out the saturation of the 13- 14 double bond of all-trans-retinol to produce all-trans-13,14- dihydroretinol. Has activity toward all-trans-retinol as substrate. Does not use all-trans-retinoic acid nor 9-cis, 11-cis or 13-cis-retinol isomers as substrates. May play a role in the metabolism of vitamin A (By similarity). {ECO:0000250}.
Induction Down-regulated in mammary adenocarcinomas
Induction Down-regulated in mammary adenocarcinomas. {ECO:0000269|PubMed:11753649}.
Similarity Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily
Similarity Belongs to the carotenoid/retinoid oxidoreductase family. CrtISO subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein .
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity Highly expressed in liver, kidney and heart
Tissue Specificity Highly expressed in liver, kidney and heart. {ECO:0000269|PubMed:11753649}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012975 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
21489985 RefSeq NP_659552 609 all-trans-retinol 13,14-reductase precursor

Identical Sequences to LMP012975 proteins

Reference Database Accession Length Protein Name
GI:21489985 GenBank AAL73494.1 609 hypothetical protein RMT-7 [Rattus norvegicus]
GI:21489985 SwissProt Q8VHE9.1 609 RecName: Full=All-trans-retinol 13,14-reductase; AltName: Full=All-trans-13,14-dihydroretinol saturase; Short=RetSat; AltName: Full=PPAR-alpha-regulated and starvation-induced gene protein; AltName: Full=RMT-7; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012975 proteins

Reference Database Accession Length Protein Name
GI:21489985 DBBJ BAE25708.1 609 unnamed protein product [Mus musculus]
GI:21489985 GenBank AAL73494.1 609 hypothetical protein RMT-7 [Rattus norvegicus]
GI:21489985 GenBank EDL91048.1 609 all-trans-13,14-dihydroretinol saturase, isoform CRA_b [Rattus norvegicus]
GI:21489985 SwissProt Q8VHE9.1 609 RecName: Full=All-trans-retinol 13,14-reductase; AltName: Full=All-trans-13,14-dihydroretinol saturase; Short=RetSat; AltName: Full=PPAR-alpha-regulated and starvation-induced gene protein; AltName: Full=RMT-7; Flags: Precursor [Rattus norvegicus]