Gene/Proteome Database (LMPD)

LMPD ID
LMP012961
Gene ID
192260
Species
Rattus norvegicus (Rat)
Gene Name
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Gene Symbol
Cdipt
Synonyms
Pis; Pis1;
Alternate Names
CDP-diacylglycerol--inositol 3-phosphatidyltransferase; PI synthase; ptdIns synthase; phosphatidylinositol synthase; CDP-diacylglycerol-inositol 3-phosphatidyltransferase;
Chromosome
1
Map Location
1q36
EC Number
2.7.8.11
Summary
catalyzes the formation of phosphatidylinositol and CMP from CDP-diacylglycerol and myo-inositol [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Cdipt

Proteins

CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Refseq ID NP_620254
Protein GI 20302093
UniProt ID P70500
mRNA ID NM_138899
Length 213
MPEENIFLFVPNLIGYARIVFAIISFYFMPCCPFTASSFYLLSGLLDAFDGHAARALNQGTRFGAMLDMLTDRCATMCLLVNLALLYPRATLLFQLSMSLDVASHWLHLHSSVVRGSESHKMIDLSGNPVLRIYYTSRPALFTLCAGNELFYCLLYLFNFSEGPLVGSVGLFRMGLWITAPIALLKSIISVIHLVTAARNMAALDAADRAKKK

Gene Information

Entrez Gene ID
192260
Gene Name
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Gene Symbol
Cdipt
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 ISS:UniProtKB C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0003881 IDA:RGD F CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
GO:0043178 IPI:RGD F alcohol binding
GO:0030246 IPI:RGD F carbohydrate binding
GO:0019992 IPI:RGD F diacylglycerol binding
GO:0030145 IDA:RGD F manganese ion binding
GO:0046341 IDA:RGD P CDP-diacylglycerol metabolic process
GO:0006661 IDA:RGD P phosphatidylinositol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5954475 Synthesis of PI

Domain Information

InterPro Annotations

Accession Description
IPR000462 CDP-alcohol phosphatidyltransferase
IPR014387 CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote

UniProt Annotations

Entry Information

Gene Name
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Protein Entry
CDIPT_RAT
UniProt ID
P70500
Species
Rat

Comments

Comment Type Description
Catalytic Activity CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol. {ECO:0000269|PubMed:3032971, ECO:0000269|PubMed:7998949}.
Cofactor Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:3032971, ECO:0000269|PubMed:7998949}; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:3032971, ECO:0000269|PubMed:7998949}; Note=Divalent metal cations; Mn(2+) or Mg(2+) (PubMed:3032971). According to PubMed:7998949 the cofactor is Mn(2+), while Mg(2+) is much less effective. {ECO:0000269|PubMed:3032971, ECO:0000269|PubMed:7998949};
Function Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme
Induction Inhibited by PtdIns (product inhibition).
Similarity Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Membrane.
Tissue Specificity Detected in liver (at protein level). Widely expressed. Highly expressed in the brain and kidney; lower levels in heart, spleen, lung, liver, skeletal muscle and testis

Identical and Related Proteins

Unique RefSeq proteins for LMP012961 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
20302093 RefSeq NP_620254 213 CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Identical Sequences to LMP012961 proteins

Reference Database Accession Length Protein Name
GI:20302093 GenBank AAH70876.1 213 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) [Rattus norvegicus]
GI:20302093 GenBank EDM17333.1 213 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase), isoform CRA_a [Rattus norvegicus]
GI:20302093 GenBank EDM17334.1 213 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase), isoform CRA_a [Rattus norvegicus]
GI:20302093 RefSeq XP_006230270.1 213 PREDICTED: CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1 [Rattus norvegicus]

Related Sequences to LMP012961 proteins

Reference Database Accession Length Protein Name
GI:20302093 DBBJ BAA82112.1 213 phosphatidylinositol synthase [Rattus norvegicus]
GI:20302093 GenBank AAQ80838.1 213 Sequence 3 from patent US 6395468
GI:20302093 RefSeq XP_006230270.1 213 PREDICTED: CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1 [Rattus norvegicus]
GI:20302093 SwissProt P70500.1 213 RecName: Full=CDP-diacylglycerol--inositol 3-phosphatidyltransferase; AltName: Full=Phosphatidylinositol synthase; Short=PI synthase; Short=PtdIns synthase [Rattus norvegicus]