Gene/Proteome Database (LMPD)

LMPD ID
LMP012933
Gene ID
171088
Species
Rattus norvegicus (Rat)
Gene Name
inositol polyphosphate-5-phosphatase J
Gene Symbol
Inpp5j
Synonyms
Inpp; Pipp; Pib5pa;
Alternate Names
phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; inositol polyphosphate 5-phosphatase J; proline-rich inositol polyphosphate 5-phosphatase; phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A;
Chromosome
14
Map Location
14q21
EC Number
3.1.3.56
Summary
hydrolyzes phosphate at the D-5 position of inositol or phosphatidylinositol polyphosphates; may mediate the level of inositol and phosphatidylinositol polyphosphates at membrane ruffles [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Inpp5j

Proteins

phosphatidylinositol 4,5-bisphosphate 5-phosphatase A
Refseq ID NP_598246
Protein GI 19424246
UniProt ID Q9JMC1
mRNA ID NM_133562
Length 1001
MEGQSRSGSAKSGTRTGLGPLPGTHGALQTGTPSKKVNSSFQLPAKNTGPTPSEPRLALAPVGPRAAVSPPSERPRLALSSPRPILAPLSTAGEQKRPPPHRSSKPAPTSVGQLVVSAAAGPKPPPVASVSILAPKSLGQLVISASAMPRPTPAPLGPILSPTSRDQKQLSPTSVGPKPALATSGLSLALASQEQPPQSPSSPSPVPSPVLSPSQESHLAPATVTSTPASERQLPARQKDTAVRRPIPPADGCLHTPVQAAGLATSPPRAQTSSDPRLSPSFRARPEAPRHSPEDPVLPPPPQTLPLDVSSGLPESGTRSPGLLSPTFRPGIPSNQTVPPPLPKPPRSPSRSPSRSPNRSPCVPPAPEVALPRPVTQGAGPGKCPSPNLQTQESPVATATSPTSSWSAQPTCKSDPGFRITVVTWNVGTAMPPDDVTSLLHLGGGHDSDGADMIAIGLQEVNSMINKRLKDALFTDQWSELFMDALGPFNFVLVSTVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAHGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSNQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPSGGPSPSGRESHRLQVTQHSYRSHMEYTVSDHKPVAARFLLQFAFRDDVPLVRLEVADEWARPEQAVVRYRVETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKHEEVDGNIYQVTFSEESLPKGHGDFILGYYSHHHSILIGVTEPFQISLPTSESASSSTDSSGTSSEGEDDSTLELLAPKSRSPSPGKSKRHRSRSPGLARFPSLALRPSSRERRGGSRSPSPQSRQLPRVAPDRGHSSGSRGSSEEGPSGPPGPWAFPPAVPRSLGLLPALRLETVDPGGGGSWGPDQEAPDPNSLSPSPQGRLGLEDGGLGP

Gene Information

Entrez Gene ID
171088
Gene Name
inositol polyphosphate-5-phosphatase J
Gene Symbol
Inpp5j
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:RGD C cytoplasm
GO:0043198 IEA:Ensembl C dendritic shaft
GO:0030426 IDA:RGD C growth cone
GO:0005886 IEA:Ensembl C plasma membrane
GO:0001726 IDA:RGD C ruffle
GO:0052659 IEA:UniProtKB-EC F inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO:0052658 IEA:UniProtKB-EC F inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0004445 IDA:RGD F inositol-polyphosphate 5-phosphatase activity
GO:0034485 IEA:Ensembl F phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0031115 IMP:RGD P negative regulation of microtubule polymerization
GO:0010977 IMP:RGD P negative regulation of neuron projection development
GO:0033137 IEA:Ensembl P negative regulation of peptidyl-serine phosphorylation
GO:0046856 IEA:InterPro P phosphatidylinositol dephosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00131 Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5954515 Inositol phosphate metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954478 PI Metabolism
5953474 Phospholipid metabolism
5954516 Synthesis of IP2, IP, and Ins in the cytosol
5954514 Synthesis of IP3 and IP4 in the cytosol
5954499 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR005135 Endonuclease/exonuclease/phosphatase
IPR000300 Inositol polyphosphate-related phosphatase

UniProt Annotations

Entry Information

Gene Name
inositol polyphosphate-5-phosphatase J
Protein Entry
PI5PA_RAT
UniProt ID
Q9JMC1
Species
Rat

Comments

Comment Type Description
Catalytic Activity 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate
Catalytic Activity D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate
Domain The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein.
Function Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate- binding proteins that are present at membranes ruffles.
Ptm Phosphorylated on Ser/Thr residues.
Similarity Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type II family
Subcellular Location Cytoplasm . Note=Predominantly localized to membrane ruffles.
Tissue Specificity Expressed in heart, brain, kidney, stomach, small intestine and lung. Not expressed in spleen, thymus, skeletal muscle, testis and skin

Identical and Related Proteins

Unique RefSeq proteins for LMP012933 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
19424246 RefSeq NP_598246 1001 phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

Identical Sequences to LMP012933 proteins

Reference Database Accession Length Protein Name
GI:19424246 DBBJ BAA90553.1 1001 proline-rich inositol polyphosphate 5-phosphatase [Rattus norvegicus]
GI:19424246 GenBank ABA09102.1 1001 Sequence 3 from patent US 6908743
GI:19424246 GenBank EDM00181.1 1001 phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A [Rattus norvegicus]
GI:19424246 SwissProt Q9JMC1.1 1001 RecName: Full=Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; AltName: Full=Inositol polyphosphate 5-phosphatase J; AltName: Full=Proline-rich inositol polyphosphate 5-phosphatase [Rattus norvegicus]

Related Sequences to LMP012933 proteins

Reference Database Accession Length Protein Name
GI:19424246 DBBJ BAA90553.1 1001 proline-rich inositol polyphosphate 5-phosphatase [Rattus norvegicus]
GI:19424246 GenBank ABA09102.1 1001 Sequence 3 from patent US 6908743
GI:19424246 GenBank EDM00181.1 1001 phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A [Rattus norvegicus]
GI:19424246 SwissProt Q9JMC1.1 1001 RecName: Full=Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; AltName: Full=Inositol polyphosphate 5-phosphatase J; AltName: Full=Proline-rich inositol polyphosphate 5-phosphatase [Rattus norvegicus]