Gene/Proteome Database (LMPD)

LMPD ID
LMP012924
Gene ID
170897
Species
Rattus norvegicus (Rat)
Gene Name
sphingosine kinase 1
Gene Symbol
Sphk1
Alternate Names
sphingosine kinase 1; SK 1; SPK 1;
Chromosome
10
Map Location
10q32.3
EC Number
2.7.1.91;
Summary
catalyzes the conversion of sphingosine to sphingosine 1 phosphate, which plays a role in cell proliferation and differentiation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Sphk1

Proteins

sphingosine kinase 1 isoform a
Refseq ID NP_001257740
Protein GI 399154142
UniProt ID Q91V26
mRNA ID NM_001270811
Length 458
MQLDSPPTSKDLAASGNDEGALTAQGGGEGEPHGQSPDTRLGNTDKQLHTGAAVTSSSAGAASVAPCQREPRDLAMQPADCPRGLLPRPCRVLVLLNPRGGKGKALKLFQSRVRPLLEEAEVSFKLMLTERQNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMERPDWESAIQKPLCSLPGGSGNALAASLNYYAGHEQVTNEDLLINCTLLLCCRQLSPMNLLSLHTASGRQLYSVLSLSWGFVADVDLESEKYRSLGEIRFTVGTFFRLASLRIYQGQLAYLPVGKAASKIPASSLAQKGPANTYLVPLEEPVPPHWTVVPEQDFVLVLVLLHTHLSTEMFAAPMGRCEAGVMHLFYIRAGVSRAMLLRLFLAMQKGKHMDLDCPYLVHVPVVAFRLEPRNQRGVFSVDGELMVCEAVQGQVHPNYLWMVSGSSDSPSGRDSQRRPPPEEPI
sphingosine kinase 1 isoform b
Refseq ID NP_001257736
Protein GI 399154133
UniProt ID Q91V26
mRNA ID NM_001270807
Length 383
MQPADCPRGLLPRPCRVLVLLNPRGGKGKALKLFQSRVRPLLEEAEVSFKLMLTERQNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMERPDWESAIQKPLCSLPGGSGNALAASLNYYAGHEQVTNEDLLINCTLLLCCRQLSPMNLLSLHTASGRQLYSVLSLSWGFVADVDLESEKYRSLGEIRFTVGTFFRLASLRIYQGQLAYLPVGKAASKIPASSLAQKGPANTYLVPLEEPVPPHWTVVPEQDFVLVLVLLHTHLSTEMFAAPMGRCEAGVMHLFYIRAGVSRAMLLRLFLAMQKGKHMDLDCPYLVHVPVVAFRLEPRNQRGVFSVDGELMVCEAVQGQVHPNYLWMVSGSSDSPSGRDSQRRPPPEEPI
sphingosine kinase 1 isoform b
Refseq ID NP_001257737
Protein GI 399154135
UniProt ID Q91V26
mRNA ID NM_001270808
Length 383
Protein sequence is identical to GI:399154133 (mRNA isoform)
sphingosine kinase 1 isoform b
Refseq ID NP_001257739
Protein GI 399154139
UniProt ID Q91V26
mRNA ID NM_001270810
Length 383
Protein sequence is identical to GI:399154133 (mRNA isoform)
sphingosine kinase 1 isoform b
Refseq ID NP_596877
Protein GI 52345437
UniProt ID Q91V26
mRNA ID NM_133386
Length 383
Protein sequence is identical to GI:399154133 (mRNA isoform)
sphingosine kinase 1 isoform b
Refseq ID NP_001257738
Protein GI 399154137
UniProt ID Q91V26
mRNA ID NM_001270809
Length 383
Protein sequence is identical to GI:399154133 (mRNA isoform)

Gene Information

Entrez Gene ID
170897
Gene Name
sphingosine kinase 1
Gene Symbol
Sphk1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030424 IDA:RGD C axon
GO:0005737 ISS:UniProtKB C cytoplasm
GO:0005829 IDA:RGD C cytosol
GO:0043005 IDA:RGD C neuron projection
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005886 IDA:RGD C plasma membrane
GO:0008021 IDA:RGD C synaptic vesicle
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0017050 ISS:UniProtKB F D-erythro-sphingosine kinase activity
GO:0003677 IEA:Ensembl F DNA binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0004143 IEA:InterPro F diacylglycerol kinase activity
GO:0000287 ISS:UniProtKB F magnesium ion binding
GO:0008481 IEA:UniProtKB-EC F sphinganine kinase activity
GO:0001568 IEA:Ensembl P blood vessel development
GO:0007420 IEA:Ensembl P brain development
GO:0019722 IEA:Ensembl P calcium-mediated signaling
GO:0071363 IEP:RGD P cellular response to growth factor stimulus
GO:0070301 IEP:RGD P cellular response to hydrogen peroxide
GO:0009267 IEP:RGD P cellular response to starvation
GO:0019371 IDA:RGD P cyclooxygenase pathway
GO:0007565 IEP:RGD P female pregnancy
GO:0006954 IEA:Ensembl P inflammatory response
GO:0043066 IMP:RGD P negative regulation of apoptotic process
GO:0042346 ISS:UniProtKB P positive regulation of NF-kappaB import into nucleus
GO:0051092 ISS:UniProtKB P positive regulation of NF-kappaB transcription factor activity
GO:0045766 IEA:Ensembl P positive regulation of angiogenesis
GO:0030307 IEA:Ensembl P positive regulation of cell growth
GO:0030335 IMP:RGD P positive regulation of cell migration
GO:0048146 IEA:Ensembl P positive regulation of fibroblast proliferation
GO:0045931 IEA:Ensembl P positive regulation of mitotic cell cycle
GO:0010976 IMP:RGD P positive regulation of neuron projection development
GO:0001956 IMP:RGD P positive regulation of neurotransmitter secretion
GO:0001934 IMP:RGD P positive regulation of protein phosphorylation
GO:0031398 ISS:UniProtKB P positive regulation of protein ubiquitination
GO:0045987 IEA:Ensembl P positive regulation of smooth muscle contraction
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0032651 IEA:Ensembl P regulation of interleukin-1 beta production
GO:0010803 ISS:UniProtKB P regulation of tumor necrosis factor-mediated signaling pathway
GO:0033198 IEP:RGD P response to ATP
GO:0014075 IEP:RGD P response to amine
GO:0070555 IEP:RGD P response to interleukin-1
GO:0032026 IEP:RGD P response to magnesium ion
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0032570 IEP:RGD P response to progesterone
GO:0006670 ISS:UniProtKB P sphingosine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko04666 Fc gamma R-mediated phagocytosis
rno04666 Fc gamma R-mediated phagocytosis
rno01100 Metabolic pathways
ko00600 Sphingolipid metabolism
rno00600 Sphingolipid metabolism
M00100 Sphingosine degradation
ko05152 Tuberculosis
rno05152 Tuberculosis
ko04370 VEGF signaling pathway
rno04370 VEGF signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954190 Association of TriC/CCT with target proteins during biosynthesis
5954184 Chaperonin-mediated protein folding
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953345 Metabolism of proteins
5954185 Protein folding
5953381 Signal Transduction
5953420 Signaling by VEGF
5954266 Sphingolipid de novo biosynthesis
5954267 Sphingolipid metabolism
5953419 VEGFA-VEGFR2 Pathway
5953418 VEGFR2 mediated cell proliferation

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR001206 Diacylglycerol kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
sphingosine kinase 1
Protein Entry
SPHK1_RAT
UniProt ID
Q91V26
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + sphinganine = ADP + sphinganine 1- phosphate.
Catalytic Activity ATP + sphingosine = ADP + sphingosine 1- phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ;
Function Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol (By similarity)
Miscellaneous Sphingosine 1-phosphate stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling
Similarity Contains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Subcellular Location Cytoplasm . Nucleus . Cell membrane. Note=Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner
Subunit Interacts with CIB1, the interaction occurs in a calcium- dependent manner (By similarity). Binds to calmodulin. Interacts with SPHKAP. Interacts with ACY1

Identical and Related Proteins

Unique RefSeq proteins for LMP012924 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
399154142 RefSeq NP_001257740 458 sphingosine kinase 1 isoform a
399154133 RefSeq NP_001257736 383 sphingosine kinase 1 isoform b

Identical Sequences to LMP012924 proteins

Reference Database Accession Length Protein Name
GI:399154135 RefSeq NP_001257736.1 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:399154137 RefSeq NP_001257736.1 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:399154139 RefSeq NP_001257736.1 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:52345437 RefSeq NP_001257737.1 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:399154133 RefSeq NP_001257737.1 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:399154137 RefSeq NP_001257737.1 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:399154139 RefSeq NP_001257737.1 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:52345437 RefSeq NP_001257738.1 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:399154133 RefSeq NP_001257738.1 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:399154135 RefSeq NP_001257738.1 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:399154139 RefSeq NP_001257738.1 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:52345437 RefSeq NP_001257739.1 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:399154133 RefSeq NP_001257739.1 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:399154135 RefSeq NP_001257739.1 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:399154137 RefSeq NP_001257739.1 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:52345437 RefSeq XP_006247850.1 383 PREDICTED: sphingosine kinase 1 isoform X1 [Rattus norvegicus]
GI:399154133 RefSeq XP_006247850.1 383 PREDICTED: sphingosine kinase 1 isoform X1 [Rattus norvegicus]
GI:399154135 RefSeq XP_006247850.1 383 PREDICTED: sphingosine kinase 1 isoform X1 [Rattus norvegicus]
GI:399154137 RefSeq XP_006247850.1 383 PREDICTED: sphingosine kinase 1 isoform X1 [Rattus norvegicus]
GI:399154139 RefSeq XP_006247850.1 383 PREDICTED: sphingosine kinase 1 isoform X1 [Rattus norvegicus]

Related Sequences to LMP012924 proteins

Reference Database Accession Length Protein Name
GI:399154142 GenBank ABF30968.1 458 sphingosine kinase 1 long isoform [Rattus norvegicus]
GI:399154142 GenBank EDL34583.1 505 sphingosine kinase 1, isoform CRA_c, partial [Mus musculus]
GI:399154139 GenBank EDM06676.1 383 sphingosine kinase 1, isoform CRA_a [Rattus norvegicus]
GI:399154133 GenBank EDM06676.1 383 sphingosine kinase 1, isoform CRA_a [Rattus norvegicus]
GI:399154135 GenBank EDM06676.1 383 sphingosine kinase 1, isoform CRA_a [Rattus norvegicus]
GI:52345437 GenBank EDM06676.1 383 sphingosine kinase 1, isoform CRA_a [Rattus norvegicus]
GI:399154137 GenBank EDM06676.1 383 sphingosine kinase 1, isoform CRA_a [Rattus norvegicus]
GI:399154139 GenBank EDM06677.1 383 sphingosine kinase 1, isoform CRA_a [Rattus norvegicus]
GI:399154135 GenBank EDM06677.1 383 sphingosine kinase 1, isoform CRA_a [Rattus norvegicus]
GI:399154137 GenBank EDM06677.1 383 sphingosine kinase 1, isoform CRA_a [Rattus norvegicus]
GI:399154133 GenBank EDM06677.1 383 sphingosine kinase 1, isoform CRA_a [Rattus norvegicus]
GI:52345437 GenBank EDM06677.1 383 sphingosine kinase 1, isoform CRA_a [Rattus norvegicus]
GI:399154133 GenBank EDM06678.1 383 sphingosine kinase 1, isoform CRA_a [Rattus norvegicus]
GI:399154137 GenBank EDM06678.1 383 sphingosine kinase 1, isoform CRA_a [Rattus norvegicus]
GI:399154135 GenBank EDM06678.1 383 sphingosine kinase 1, isoform CRA_a [Rattus norvegicus]
GI:399154139 GenBank EDM06678.1 383 sphingosine kinase 1, isoform CRA_a [Rattus norvegicus]
GI:52345437 GenBank EDM06678.1 383 sphingosine kinase 1, isoform CRA_a [Rattus norvegicus]
GI:399154137 RefSeq NP_596877.2 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:399154133 RefSeq NP_596877.2 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:399154135 RefSeq NP_596877.2 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:399154139 RefSeq NP_596877.2 383 sphingosine kinase 1 isoform b [Rattus norvegicus]
GI:399154142 RefSeq XP_006532731.1 512 PREDICTED: sphingosine kinase 1 isoform X1 [Mus musculus]