Gene/Proteome Database (LMPD)

LMPD ID
LMP012923
Gene ID
170818
Species
Rattus norvegicus (Rat)
Gene Name
isoprenylcysteine carboxyl methyltransferase
Gene Symbol
Icmt
Synonyms
fcmt;
Alternate Names
protein-S-isoprenylcysteine O-methyltransferase; PPMT; pcCMT; prenylcysteine carboxyl methlytransferase; prenylcysteine carboxyl methyltransferase; farnesyl cysteine carboxyl methyltransferase; prenylated protein carboxyl methyltransferase;
Chromosome
5
Map Location
5q36
Summary
mouse homolog is an enzyme necessary for carboxyl methylation; required for isoprenylation of Ras [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Icmt

Proteins

protein-S-isoprenylcysteine O-methyltransferase
Refseq ID NP_579844
Protein GI 158138563
UniProt ID G3V7G5
mRNA ID NM_133310
Length 284
MAGCAARVPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGVLLSFSQSSWNHFGWYVCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWIEFTLENIFWPELKQITWLSAAGLLMVIFGECLRKVAMFTAGSNFNHVVQSEKSDTHTLVTSGVYAWCRHPSYVGWFYWSIGTQVMLCNPICGVVYALTVWRFFRDRTEEEEISLIHFFGEEYLDYKKRVPTGLPFIKGVKVGL

Gene Information

Entrez Gene ID
170818
Gene Name
isoprenylcysteine carboxyl methyltransferase
Gene Symbol
Icmt
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:Ensembl C endoplasmic reticulum
GO:0016021 IEA:InterPro C integral component of membrane
GO:0008140 IEA:Ensembl F cAMP response element binding protein binding
GO:0004671 IEA:Ensembl F protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
GO:0001701 IEA:Ensembl P in utero embryonic development
GO:0001889 IEA:Ensembl P liver development
GO:0035264 IEA:Ensembl P multicellular organism growth
GO:0008284 IEA:Ensembl P positive regulation of cell proliferation
GO:0008104 IEA:Ensembl P protein localization
GO:0046578 IEA:Ensembl P regulation of Ras protein signal transduction

KEGG Pathway Links

KEGG Pathway ID Description
ko00900 Terpenoid backbone biosynthesis
rno00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR007269 Isoprenylcysteine carboxyl methyltransferase
IPR025770 Protein-S-isoprenylcysteine O-methyltransferase

UniProt Annotations

Entry Information

Gene Name
isoprenylcysteine carboxyl methyltransferase
Protein Entry
G3V7G5_RAT
UniProt ID
G3V7G5
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012923 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158138563 RefSeq NP_579844 284 protein-S-isoprenylcysteine O-methyltransferase

Identical Sequences to LMP012923 proteins

Reference Database Accession Length Protein Name
GI:158138563 GenBank EDL81231.1 284 isoprenylcysteine carboxyl methyltransferase [Rattus norvegicus]

Related Sequences to LMP012923 proteins

Reference Database Accession Length Protein Name
GI:158138563 DBBJ BAE32399.1 284 unnamed protein product [Mus musculus]
GI:158138563 GenBank AAI10696.1 284 Icmt protein [Mus musculus]
GI:158138563 GenBank EDL81231.1 284 isoprenylcysteine carboxyl methyltransferase [Rattus norvegicus]