Gene/Proteome Database (LMPD)

LMPD ID
LMP012903
Gene ID
140544
Species
Rattus norvegicus (Rat)
Gene Name
phosphate cytidylyltransferase 1, choline, alpha
Gene Symbol
Pcyt1a
Synonyms
CTP; CCT-alpha;
Alternate Names
choline-phosphate cytidylyltransferase A; CT A; CCT A; phosphorylcholine transferase A; CTP:phosphocholine cytidylyl transferase; CTP:phosphocholine cytidylyltransferase A; CTP:phosphocholine cytidylyltransferase alpha; choline phosphate cytidylyltransferase 1 alpha; phosphate cytidylyltransferase 1, choline, alpha isoform;
Chromosome
11
Map Location
11q22
EC Number
2.7.7.15
Summary
catalyzes rate-limiting synthesis of phosphotidylcholine; plays a key role in cell membrane synthesis and in supply of lipid second messenger [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pcyt1a

Proteins

choline-phosphate cytidylyltransferase A
Refseq ID NP_511177
Protein GI 53828922
UniProt ID P19836
mRNA ID NM_078622
Length 367
MDAQSSAKVNSRKRRKEVPGPNGATEEDGIPSKVQRCAVGLRQPAPFSDEIEVDFSKPYVRVTMEEACRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTHERSPSPSFRWPFSGKTSPSSSPASLSRCKAVTCDISEDEED

Gene Information

Entrez Gene ID
140544
Gene Name
phosphate cytidylyltransferase 1, choline, alpha
Gene Symbol
Pcyt1a
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:Ensembl C endoplasmic reticulum membrane
GO:0019898 NAS:RGD C extrinsic component of membrane
GO:0042587 IEA:Ensembl C glycogen granule
GO:0004105 IDA:UniProtKB F choline-phosphate cytidylyltransferase activity
GO:0008289 IMP:RGD F lipid binding
GO:0042803 IPI:UniProtKB F protein homodimerization activity
GO:0006657 IDA:UniProtKB P CDP-choline pathway
GO:0006656 TAS:RGD P phosphatidylcholine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways
M00090 Phosphatidylcholine (PC) biosynthesis, choline => PC

REACTOME Pathway Links

REACTOME Pathway ID Description
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5954091 Synthesis of PC

Domain Information

InterPro Annotations

Accession Description
IPR004821 Cytidyltransferase-like domain
IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

UniProt Annotations

Entry Information

Gene Name
phosphate cytidylyltransferase 1, choline, alpha
Protein Entry
PCY1A_RAT
UniProt ID
P19836
Species
Rat

Comments

Comment Type Description
Catalytic Activity CTP + phosphocholine = diphosphate + CDP- choline. {ECO:0000269|PubMed:12718547, ECO:0000269|PubMed:19783652}.
Enzyme Regulation By phosphorylation.
Function Controls phosphatidylcholine synthesis.
Miscellaneous The cytidylyltransferase may interact with membranes through its amphipathic helix.
Pathway Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.
Ptm Monoubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation
Ptm The N-terminus is blocked.
Ptm The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation
Similarity Belongs to the cytidylyltransferase family
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:639816}. Membrane ; Peripheral membrane protein . Note=It can interconvert between an inactive cytosolic form and an active membrane-bound form.
Subunit Homodimer

Identical and Related Proteins

Unique RefSeq proteins for LMP012903 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
53828922 RefSeq NP_511177 367 choline-phosphate cytidylyltransferase A

Identical Sequences to LMP012903 proteins

Reference Database Accession Length Protein Name
GI:53828922 GenBank EDM11415.1 367 phosphate cytidylyltransferase 1, choline, alpha isoform, isoform CRA_a [Rattus norvegicus]
GI:53828922 GenBank EDM11416.1 367 phosphate cytidylyltransferase 1, choline, alpha isoform, isoform CRA_a [Rattus norvegicus]
GI:53828922 RefSeq XP_006248506.1 367 PREDICTED: choline-phosphate cytidylyltransferase A isoform X1 [Rattus norvegicus]
GI:53828922 RefSeq XP_008766916.1 367 PREDICTED: choline-phosphate cytidylyltransferase A isoform X1 [Rattus norvegicus]

Related Sequences to LMP012903 proteins

Reference Database Accession Length Protein Name
GI:53828922 GenBank AAB59683.1 367 CTP:phosphocholine cytidylyltransferase, partial [Rattus norvegicus]
GI:53828922 RefSeq XP_008766916.1 367 PREDICTED: choline-phosphate cytidylyltransferase A isoform X1 [Rattus norvegicus]
GI:53828922 SwissProt P19836.2 367 RecName: Full=Choline-phosphate cytidylyltransferase A; AltName: Full=CCT-alpha; AltName: Full=CTP:phosphocholine cytidylyltransferase A; Short=CCT A; Short=CT A; AltName: Full=Phosphorylcholine transferase A [Rattus norvegicus]