Gene/Proteome Database (LMPD)

LMPD ID
LMP012900
Gene ID
117543
Species
Rattus norvegicus (Rat)
Gene Name
2,4-dienoyl CoA reductase 1, mitochondrial
Gene Symbol
Decr1
Alternate Names
2,4-dienoyl-CoA reductase, mitochondrial; 4-enoyl-CoA reductase;
Chromosome
5
Map Location
5q13
EC Number
1.3.1.34
Summary
catalyzes the conversion of trans-2,3-didehydroacyl-CoA and NADP(+) to trans,trans-2,3,4,5-tetradehydroacyl-CoA and NADPH [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Decr1

Proteins

2,4-dienoyl-CoA reductase, mitochondrial precursor
Refseq ID NP_476545
Protein GI 292781228
UniProt ID Q64591
mRNA ID NM_057197
Length 335
MALLARAFFAGVSRLPCDPGPQRFFSFGTKTLYQSIDAPQSKFFPPILKPMLPPNAFQGKVAFITGGGTGLGKAMTTFLSSLGAQCVIASRNIDVLKATAEEITSKTGNKVYAIRCDVRDPDMVHNTVLELIKVAGHPDVVINNAAGNFISPSERLSPNGWKTITDIVLNGTAYVTLEIGKQLIKAQKGAAFLAITTIYAESGSGFVMPSSSAKSGVEAMNKSLAAEWGRYGMRFNIIQPGPIKTKGAFSRLDPTGKFEKDMIERIPCGRLGTVEELANLATFLCSDYASWINGAVIRFDGGEEVFLSGEFNSLKKVTKEEWDVIEGLIRKTKGS
transit_peptide: 1..34 calculated_mol_wt: 3794 peptide sequence: MALLARAFFAGVSRLPCDPGPQRFFSFGTKTLYQ mat_peptide: 35..335 product: 2,4-dienoyl-CoA reductase, mitochondrial calculated_mol_wt: 32356 peptide sequence: SIDAPQSKFFPPILKPMLPPNAFQGKVAFITGGGTGLGKAMTTFLSSLGAQCVIASRNIDVLKATAEEITSKTGNKVYAIRCDVRDPDMVHNTVLELIKVAGHPDVVINNAAGNFISPSERLSPNGWKTITDIVLNGTAYVTLEIGKQLIKAQKGAAFLAITTIYAESGSGFVMPSSSAKSGVEAMNKSLAAEWGRYGMRFNIIQPGPIKTKGAFSRLDPTGKFEKDMIERIPCGRLGTVEELANLATFLCSDYASWINGAVIRFDGGEEVFLSGEFNSLKKVTKEEWDVIEGLIRKTKGS

Gene Information

Entrez Gene ID
117543
Gene Name
2,4-dienoyl CoA reductase 1, mitochondrial
Gene Symbol
Decr1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0008670 ISS:UniProtKB F 2,4-dienoyl-CoA reductase (NADPH) activity
GO:0006635 ISS:UniProtKB P fatty acid beta-oxidation

REACTOME Pathway Links

REACTOME Pathway ID Description
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953287 Mitochondrial Fatty Acid Beta-Oxidation
5953518 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
2,4-dienoyl CoA reductase 1, mitochondrial
Protein Entry
DECR_RAT
UniProt ID
Q64591
Species
Rat

Comments

Comment Type Description
Catalytic Activity Trans-2,3-didehydroacyl-CoA + NADP(+) = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH.
Function Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily
Subcellular Location Mitochondrion.
Subunit Homotetramer

Identical and Related Proteins

Unique RefSeq proteins for LMP012900 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
292781228 RefSeq NP_476545 335 2,4-dienoyl-CoA reductase, mitochondrial precursor

Identical Sequences to LMP012900 proteins

Reference Database Accession Length Protein Name
GI:292781228 GenBank EDL98478.1 335 2,4-dienoyl CoA reductase 1, mitochondrial, isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP012900 proteins

Reference Database Accession Length Protein Name
GI:292781228 GenBank AAO99136.1 335 Sequence 7 from patent US 6511833
GI:292781228 GenBank EDL98478.1 335 2,4-dienoyl CoA reductase 1, mitochondrial, isoform CRA_a [Rattus norvegicus]
GI:292781228 SwissProt Q64591.2 335 RecName: Full=2,4-dienoyl-CoA reductase, mitochondrial; AltName: Full=2,4-dienoyl-CoA reductase [NADPH]; Short=4-enoyl-CoA reductase [NADPH]; Flags: Precursor [Rattus norvegicus]