Gene/Proteome Database (LMPD)

LMPD ID
LMP012892
Gene ID
117185
Species
Rattus norvegicus (Rat)
Gene Name
sialidase 3 (membrane sialidase)
Gene Symbol
Neu3
Alternate Names
sialidase-3; neuraminidase 3; membrane sialidase; ganglioside sialidase; N-acetyl-alpha-neuraminidase 3;
Chromosome
1
Map Location
1q32
EC Number
3.2.1.18
Summary
enzyme that cleaves sialic acid from glycoproteins and glycolipids [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Neu3

Proteins

sialidase-3
Refseq ID NP_446462
Protein GI 16758932
UniProt ID Q99PW5
mRNA ID NM_054010
Length 418
MEEVSSCSLRSTLFQQEEQNRITYRIPALLYIPPTHTFLAFAEMRTSSRDEDAVYLVFRRGVMKGCSVEWGPQQPLMEATLPGHRTMSPCPVWEKNTGRVYLFFICVQGHVSERWQLLWGRNAARLCFLYSEDSGCSWGEVKDLTEEVVGSEMKHWATFAVGPGHGIQLQSGRLLIPAYAYLISCWFLCFPCSVKPHSLMFYSDDLGVTWHCGKFIKPQVTGECQVAEVPGKAGNLVLYCSARTPNKFRAEAFSTDSGDCFQKPTLNQQLCEPRGGCQGSVVSTRPLKMPYTCQDSSGKDVPSTQKCPLMDRSLEVEEGAGAPSGTWLLYSHPTNKKKRMNLGIYYNQNPLEVNYWSRPWILNRGPSGYSDLAVVEGQGLFACLFECGERHEDEKIDFCLFSDQEVLSCDDCTSPSSN

Gene Information

Entrez Gene ID
117185
Gene Name
sialidase 3 (membrane sialidase)
Gene Symbol
Neu3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005886 ISS:UniProtKB C plasma membrane
GO:0052794 ISS:UniProtKB F exo-alpha-(2->3)-sialidase activity
GO:0052795 IEA:UniProtKB-EC F exo-alpha-(2->6)-sialidase activity
GO:0052796 ISS:UniProtKB F exo-alpha-(2->8)-sialidase activity
GO:0006689 ISS:UniProtKB P ganglioside catabolic process
GO:0009313 IEA:Ensembl P oligosaccharide catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00511 Other glycan degradation
rno00511 Other glycan degradation
ko00600 Sphingolipid metabolism
rno00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5953739 Asparagine N-linked glycosylation
5953738 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
5954485 Glycosphingolipid metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953345 Metabolism of proteins
5953728 Post-translational protein modification
5954270 Sialic acid metabolism
5954267 Sphingolipid metabolism
5953737 Synthesis of substrates in N-glycan biosythesis

Domain Information

InterPro Annotations

Accession Description
IPR026856 Sialidase family
IPR026944 Sialidase-3
IPR011040 Sialidases

UniProt Annotations

Entry Information

Gene Name
sialidase 3 (membrane sialidase)
Protein Entry
NEUR3_RAT
UniProt ID
Q99PW5
Species
Rat

Comments

Comment Type Description
Catalytic Activity Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Function Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates
Similarity Belongs to the glycosyl hydrolase 33 family
Similarity Contains 3 BNR repeats
Subcellular Location Cell membrane ; Peripheral membrane protein .
Tissue Specificity Expressed in brain, cardiac muscle and weakly in liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP012892 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16758932 RefSeq NP_446462 418 sialidase-3

Identical Sequences to LMP012892 proteins

Reference Database Accession Length Protein Name
GI:16758932 GenBank AAI00626.1 418 Sialidase 3 (membrane sialidase) [Rattus norvegicus]
GI:16758932 GenBank EDM18376.1 418 neuraminidase 3 [Rattus norvegicus]
GI:16758932 RefSeq XP_008757887.1 418 PREDICTED: sialidase-3 isoform X1 [Rattus norvegicus]
GI:16758932 SwissProt Q99PW5.1 418 RecName: Full=Sialidase-3; AltName: Full=Ganglioside sialidase; AltName: Full=Membrane sialidase; AltName: Full=N-acetyl-alpha-neuraminidase 3 [Rattus norvegicus]

Related Sequences to LMP012892 proteins

Reference Database Accession Length Protein Name
GI:16758932 DBBJ BAB32440.1 418 sialidase [Rattus norvegicus]
GI:16758932 GenBank AAI00626.1 418 Sialidase 3 (membrane sialidase) [Rattus norvegicus]
GI:16758932 GenBank EDM18376.1 418 neuraminidase 3 [Rattus norvegicus]