Gene/Proteome Database (LMPD)

LMPD ID
LMP012890
Gene ID
117039
Species
Rattus norvegicus (Rat)
Gene Name
G protein pathway suppressor 1
Gene Symbol
Gps1
Synonyms
MFH;
Alternate Names
COP9 signalosome complex subunit 1; SGN1; GPS-1; MFH protein; signalosome subunit 1; JAB1-containing signalosome subunit 1;
Chromosome
10
Map Location
chromosome:10
Summary
human homolg suppresses G-protein and mitogen-activated protein kinase mediated signal transduction [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Gps1

Proteins

COP9 signalosome complex subunit 1
Refseq ID NP_446421
Protein GI 400153471
UniProt ID P97834
mRNA ID NM_053969
Length 526
MRGSPAPSSASSSASDLSRSPAHSRSDLRPGTSGDYSLSASLSACTLLSEGAVEPMQIDVDPQEDPQNAPDVNYVVENPTLDLEQYAASYSGLMRIERLQFIADRCPPLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAIPESGVEPPPLDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHKMAAAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMILRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM
COP9 signalosome complex subunit 1 isoform 2
Refseq ID NP_001257868
Protein GI 400153475
UniProt ID P97834
mRNA ID NM_001270939
Length 487
MPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENPTLDLEQYAASYSGLMRIERLQFIADRCPPLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAIPESGVEPPPLDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHKMAAAFNTTVAALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMILRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM

Gene Information

Entrez Gene ID
117039
Gene Name
G protein pathway suppressor 1
Gene Symbol
Gps1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0008180 IEA:UniProtKB-KW C COP9 signalosome
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0010388 IEA:Ensembl P cullin deneddylation

Domain Information

InterPro Annotations

Accession Description
IPR019585 26S_proteasome_reg_su-Rpn7
IPR000717 PCI_dom
IPR011990 Tetratricopeptide-like helical domain
IPR011991 Winged helix-turn-helix DNA-binding domain

UniProt Annotations

Entry Information

Gene Name
G protein pathway suppressor 1
Protein Entry
CSN1_RAT
UniProt ID
P97834
Species
Rat

Comments

Comment Type Description
Domain The N-terminal part (1-196), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression
Domain The PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8 (By similarity)
Function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction (By similarity)
Similarity Belongs to the CSN1 family
Similarity Contains 1 PCI domain
Subcellular Location Cytoplasm . Nucleus .
Subunit Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS2, COPS3, COPS4 and CSN5. Interacts directly with inositol kinase ITPK1. Interacts with CAPN8 (By similarity)
Tissue Specificity Widely expressed. Highly expressed in testis

Identical and Related Proteins

Unique RefSeq proteins for LMP012890 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
400153471 RefSeq NP_446421 526 COP9 signalosome complex subunit 1
400153475 RefSeq NP_001257868 487 COP9 signalosome complex subunit 1 isoform 2

Identical Sequences to LMP012890 proteins

Reference Database Accession Length Protein Name
GI:400153475 GenBank AAI03783.1 487 G protein pathway suppressor 1 [Mus musculus]
GI:400153475 RefSeq NP_001171345.1 487 COP9 signalosome complex subunit 1 isoform 2 [Mus musculus]
GI:400153475 RefSeq XP_005069848.1 487 PREDICTED: COP9 signalosome complex subunit 1 isoform X4 [Mesocricetus auratus]
GI:400153471 RefSeq XP_006987713.1 526 PREDICTED: COP9 signalosome complex subunit 1 isoform X1 [Peromyscus maniculatus bairdii]
GI:400153475 RefSeq XP_006987715.1 487 PREDICTED: COP9 signalosome complex subunit 1 isoform X3 [Peromyscus maniculatus bairdii]

Related Sequences to LMP012890 proteins

Reference Database Accession Length Protein Name
GI:400153471 GenBank EDL34805.1 526 mCG2137, isoform CRA_b [Mus musculus]
GI:400153475 RefSeq NP_001171345.1 487 COP9 signalosome complex subunit 1 isoform 2 [Mus musculus]
GI:400153475 RefSeq XP_005069848.1 487 PREDICTED: COP9 signalosome complex subunit 1 isoform X4 [Mesocricetus auratus]
GI:400153471 RefSeq XP_005350956.1 526 PREDICTED: COP9 signalosome complex subunit 1 isoform X1 [Microtus ochrogaster]
GI:400153471 RefSeq XP_006987713.1 526 PREDICTED: COP9 signalosome complex subunit 1 isoform X1 [Peromyscus maniculatus bairdii]
GI:400153475 RefSeq XP_006987715.1 487 PREDICTED: COP9 signalosome complex subunit 1 isoform X3 [Peromyscus maniculatus bairdii]