LIPID MAPS

LMPD ID

LMP012886

Gene ID

116723

Species

Rattus norvegicus (Rat)

Gene Name

phosphatidylinositol-5-phosphate 4-kinase, type II, alpha

Gene Symbol

Pip4k2a

Synonyms

Pip5k2a;

Alternate Names

phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; PIPK2 alpha; PIP4KII-alpha; PI(5)P 4-kinase type II alpha; diphosphoinositide kinase 2-alpha; ptdIns(5)P-4-kinase isoform 2-alpha; 1-phosphatidylinositol-5-phosphate 4-kinase A; 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha; phosphatidylinositol-5-phosphate 4-kinase type-2 alpha; phosphatidylinositol 5-phosphate 4-kinase type II alpha; phosphatidylinositol-4-phosphate 5-kinase, type II, alpha;

Chromosome

17

Map Location

17q12.3

EC Number

2.7.1.149

Summary

mouse homolog is kinase which catalyzes the synthesis of phosphatidylinositol 4, 5-bisphosphate, an essential lipid molecule in various cellular processes [RGD, Feb 2006]

Orthologs

View orthologs and multiple alignments for Pip4k2a

phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Refseq ID	NP_446378
Protein GI	16758974
UniProt ID	Q9R0I8
mRNA ID	NM_053926
Length	406
MATPSNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYVIKTITSEDVAEMHNILKKYHQYIVECHGVTLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDSNKKIFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENEGEEEGESDGAHPIGTPPDSPGNTLNSSPPLAPGEFDPNIDVYAIKCHENAPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT

Entrez Gene ID

116723

Gene Name

phosphatidylinositol-5-phosphate 4-kinase, type II, alpha

Gene Symbol

Pip4k2a

Species

Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IEA:UniProtKB-KW	C	cytoplasm
GO:0005634	IEA:UniProtKB-KW	C	nucleus
GO:0005886	IEA:UniProtKB-KW	C	plasma membrane
GO:0016309	IEA:UniProtKB-EC	F	1-phosphatidylinositol-5-phosphate 4-kinase activity
GO:0005524	IEA:UniProtKB-KW	F	ATP binding

KEGG Pathway Links

KEGG Pathway ID	Description
ko00562	Inositol phosphate metabolism
rno00562	Inositol phosphate metabolism
ko04070	Phosphatidylinositol signaling system
rno04070	Phosphatidylinositol signaling system
ko04810	Regulation of actin cytoskeleton
rno04810	Regulation of actin cytoskeleton

InterPro Annotations

Accession	Description
IPR023610	Phosphatidylinositol-4-phosphate 5-kinase
IPR027483	Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
IPR027484	Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
IPR002498	Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034	Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup

Entry Information

Gene Name

phosphatidylinositol-5-phosphate 4-kinase, type II, alpha

Protein Entry

PI42A_RAT

UniProt ID

Q9R0I8

Species

Rat

Comments

Comment Type	Description
Catalytic Activity	ATP + 1-phosphatidyl-1D-myo-inositol 5- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Function	Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May be involved in thrombopoiesis and the terminal maturation of megakaryocytes and regulation of their size (By similarity). May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. {ECO:0000250, ECO:0000269\|PubMed:21847559}.
Similarity	Contains 1 PIPK domain. {ECO:0000255\|PROSITE- ProRule:PRU00781}.
Subcellular Location	Nucleus . Cytoplasm {ECO:0000250}. Cell membrane . Note=Localization to the nucleus is modulated by the interaction with PIP4K2B. May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light
Subunit	Homodimer. Interacts with PIP4K2B. Interaction with PIP4K2B may modulate localization to the nucleus (By similarity)

Unique RefSeq proteins for LMP012886 (as displayed in Record Overview)

Protein GI	Database	Accession	Length	Protein Name
16758974	RefSeq	NP_446378	406	phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

Identical Sequences to LMP012886 proteins

Reference	Database	Accession	Length	Protein Name
GI:16758974	DBBJ	BAA85160.1	406	phosphatidylinositol 5-phosphate 4-kinase alpha [Rattus norvegicus]
GI:16758974	SwissProt	Q9R0I8.1	406	RecName: Full=Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; AltName: Full=1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; AltName: Full=Diphosphoinositide kinase 2-alpha; AltName: Full=PIPK2 alpha; AltName: Full=Phosphatidylinositol 5-phosphate 4-kinase type II alpha; Short=PI(5)P 4-kinase type II alpha; Short=PIP4KII-alpha; AltName: Full=PtdIns(5)P-4-kinase isoform 2-alpha [Rattus norvegicus]

Related Sequences to LMP012886 proteins

Reference	Database	Accession	Length	Protein Name
GI:16758974	DBBJ	BAA85160.1	406	phosphatidylinositol 5-phosphate 4-kinase alpha [Rattus norvegicus]
GI:16758974	RefSeq	XP_004800344.1	406	PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X2 [Mustela putorius furo]
GI:16758974	SwissProt	Q9R0I8.1	406	RecName: Full=Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; AltName: Full=1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; AltName: Full=Diphosphoinositide kinase 2-alpha; AltName: Full=PIPK2 alpha; AltName: Full=Phosphatidylinositol 5-phosphate 4-kinase type II alpha; Short=PI(5)P 4-kinase type II alpha; Short=PIP4KII-alpha; AltName: Full=PtdIns(5)P-4-kinase isoform 2-alpha [Rattus norvegicus]