Gene/Proteome Database (LMPD)

LMPD ID
LMP012884
Gene ID
116719
Species
Rattus norvegicus (Rat)
Gene Name
acetyl-CoA carboxylase beta
Gene Symbol
Acacb
Synonyms
Acc2;
Alternate Names
acetyl-CoA carboxylase 2; acetyl-Coenzyme A carboxylase 2; acetyl-Coenzyme A carboxylase beta;
Chromosome
12
Map Location
12q16
Summary
catalyzes the carboxylation of acetyl-CoA to malonyl-CoA during fatty acid biosynthesis; involved in fatty acid oxidation and insulin secretion signaling [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acacb

Proteins

acetyl-CoA carboxylase 2
Refseq ID NP_446374
Protein GI 16758804
UniProt ID O70151
mRNA ID NM_053922
Length 2456
MVLLLFLTYLVFSCLTISWLKIWGKMTDSRPLSNSKVDASLLPSKEESFASDQSEEHGDCSCPLTTPDQEELASHGGPVDASQQRNSVPTSHQKPPRNPLSSNDTCSSPELQTNGVAAPGSEVPEANGLPFPARPQTQRTGSPTREDKKQAPIKRQLMTSFILGSLDDNSSDEDPSSNSFQTSSRKGSRDSLGTCSQEAALNTADPESHTPTMRPSMSGLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGNRVIETVLIANNGIAAVKWMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYYKMADPVLPVPGGPNNNNYANVELIIDIAKRIPVQAVWAGWGHASENPKLPELLCKHGIAFLGPRVRPMLGLGDRLSSTIVAQTLQIPTLPWSGSGLTVEWTEDSQHQGKCISVTEDVYEQGCVRDVDEGLQAAEKVGFPLMIKASEGGGGKGIRQAESAEDFPCFFRQVQSEIPGSPIFLMKLAQNARHLEVQVLADQYGNAVSLFGRDCSIQRRHQKIIEEAPANIAAPAVFEFMEQCAVLLAKTVVYVSAGTVGYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLLYGESPWGVTPVSFETPLSPPIARGHVIAARITSENPDEAFKPSSGTVQELNFRSNKNVWGYFSVAAAGGLHEFPISQFGHCFSWGENQEEAISNMVVALKELSIRGDFRTTVEYLVNLLETESLQNNDIDTGWLDHLIAQRVQAEKPDIMLGVVFGALNVADAMFRTCITEFLHSLERGQVLPADSLLNIVDVELIYGGIKYVLKVARQSLTMFVLIMNGCHIEIDAHRPNDGGLLLSYNGSSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSPSAGKLMQYTVEDGQHVEVGSSYAEMEVMKMIMTLNVQESGRVNYIKRPGAVLEAGCVVAKLELDDPSKVHAAQPFTGELPAQQTLPILGERLHQVFHSVLENLTNVMNGYCLPEPFFSMKLKDWVEKPMMTLRHPSLPLLELQEIMTSVADRIPVPVEKAVRRVFAQDASNITSVLCQFPSQQIATILDCHAATLQRKVDREAFFMNTQSIVQLIQRYRSGTRGIMKAVVLDLLRRYLNVEHHFQQAHYDKCVINLREQFKADMTRVLDCIFSHSQVAKKNQLVTMLIDELCGPDPTLSEELTSILKELTQLSRSEHCKVALRARQVLIASHLPSYELRHNQVESSSCQPLTCNGHQFCPENLKKLILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRELPDGTCVVEFQFMLPSSHPNRMAMPINVSDPDLLRHSKELFMDSGFSPLCHQRMGAMVAFRRFEEFTRNFDEVISCFANVPTDTPLFSKACTSLYSEEDSKSLQEEPIHILNVAIQCADHMEDERLVPVFRAFVQSKKHILVDYGLRRITFLIAQEKEFPKFFTFRARDEFAEDRIYRHLEPGLAFQLELSRMRNFDLTAVPCANHKMHLYLGAAKVKEGLEVTDHRFFIRAIIRHSDLITKEASFEYLQNEGERLLLEAMDELEVAFNNTSVRTDCNHIFLNFVAHVIMDPLKIEESVRAMVMRYGSRLWKLRVLQAQVKINIRQTTSDCAVPIRLFITNESGYYLDISLYKEVTDSRSGNIMFHSFGNKQGSLHGMLINTPYVTKDLLQAKRFQAQSLGTTYVYDFPEMFRQALFKLWGSPEKYGPDILTYTELVLDSQGQLVEMNRLPGCNEVGMVVFKMRFKTPEYPEGRDTIVIGNDITFQIGSFGIGEDFLYLRASEMARTEGIPQIYLAANSGAVLGLSEEIKQIFQVAWVDPEDPYKGFRYLYLYLTPQDYTQISSQNSVHCKHIEDEGESGIIVDVIGKDSSLGVENLRGSGMIAGEASLAYEKNVTISMVDCRAIGIGAYLVRLGQRVIQVENSHIILTGAGALNKVLGREVYTSNNQLGGVQIMHTNGVSHVTVPDDFEGVCTILEWLSYIPKDNQSPVPIITPSDPIDREIEFTPTKAPYDPRWLLAGRPHPTLKGTWQSGFFDHGSFKEIMAPWDQTVVTGRARLGGIPVGVIAVETRSVEVAVPAHPANLDSEAKIIQQAGQVWFPDSAFKTAQVIRDFNQEHLLLMIFANWRGFSGGMKDMSEQMLKFGAYIVDSLRLSKQPVLIYIPPGAELRGGSWVVLDSSINPLCIEMYADKESRGGVLEPEGTVEIKFRKKDLVKTIRRIDPVCKKLLEPAGDTQLPDKDRKELESQLKAREDLLLPIYHQVAVQFADLHDTPGHMLKKGIISDVLEWKTTRTYFYWRLRRLLLEAQVKQEILRASPELSHEHTQSMLRRWFVETEGAVKAYLWDSNQVVVQWLEQHWSARDNLRSTIRENLNYLKRDSVLKTIQSLVQEHPEATMGLCGYLSQHLTPAEQMQVVQLLSTTESPASH

Gene Information

Entrez Gene ID
116719
Gene Name
acetyl-CoA carboxylase beta
Gene Symbol
Acacb
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:RGD C mitochondrion
GO:0005524 IDA:RGD F ATP binding
GO:0003989 IDA:RGD F acetyl-CoA carboxylase activity
GO:0009374 IMP:RGD F biotin binding
GO:0004075 IEA:InterPro F biotin carboxylase activity
GO:0046872 IEA:InterPro F metal ion binding
GO:0006084 IDA:RGD P acetyl-CoA metabolic process
GO:0006633 IEA:InterPro P fatty acid biosynthetic process
GO:0042493 IEP:RGD P response to drug
GO:0014070 IMP:RGD P response to organic cyclic compound

KEGG Pathway Links

KEGG Pathway ID Description
ko04152 AMPK signaling pathway
rno04152 AMPK signaling pathway
ko04920 Adipocytokine signaling pathway
rno04920 Adipocytokine signaling pathway
ko00061 Fatty acid biosynthesis
rno00061 Fatty acid biosynthesis
M00082 Fatty acid biosynthesis, initiation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
ko04910 Insulin signaling pathway
rno04910 Insulin signaling pathway
rno01100 Metabolic pathways
ko00640 Propanoate metabolism
rno00640 Propanoate metabolism
ko00620 Pyruvate metabolism
rno00620 Pyruvate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR011761 ATP-grasp fold
IPR013815 ATP-grasp fold, subdomain 1
IPR013816 ATP-grasp fold, subdomain 2
IPR013537 Acetyl-CoA carboxylase, central domain
IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal
IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal
IPR005482 Biotin carboxylase, C-terminal
IPR011764 Biotin carboxylation domain
IPR000089 Biotin/lipoyl attachment
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR000022 Carboxyl transferase
IPR029045 ClpP/crotonase-like domain
IPR016185 Pre-ATP-grasp domain
IPR011054 Rudiment single hybrid motif
IPR011053 Single hybrid motif

UniProt Annotations

Entry Information

Gene Name
acetyl-CoA carboxylase beta
Protein Entry
O70151_RAT
UniProt ID
O70151
Species
Rat

Comments

Comment Type Description
Cofactor Note=Biotin. ;
Similarity Contains ATP-grasp domain
Similarity Contains biotin carboxylation domain
Similarity Contains biotinyl-binding domain

Identical and Related Proteins

Unique RefSeq proteins for LMP012884 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16758804 RefSeq NP_446374 2456 acetyl-CoA carboxylase 2

Identical Sequences to LMP012884 proteins

Reference Database Accession Length Protein Name
GI:16758804 GenBank AGX53765.1 2456 Sequence 7880 from patent US 8541208
GI:16758804 GenBank AGX56032.1 2456 Sequence 12390 from patent US 8541208
GI:16758804 GenBank AGX60447.1 2456 Sequence 21125 from patent US 8541208
GI:16758804 GenBank AGX77080.1 2456 Sequence 53934 from patent US 8541208

Related Sequences to LMP012884 proteins

Reference Database Accession Length Protein Name
GI:16758804 GenBank AGX52829.1 2456 Sequence 6009 from patent US 8541208
GI:16758804 GenBank AGX53765.1 2456 Sequence 7880 from patent US 8541208
GI:16758804 GenBank AGX56032.1 2456 Sequence 12390 from patent US 8541208