Gene/Proteome Database (LMPD)

LMPD ID
LMP012872
Gene ID
116551
Species
Rattus norvegicus (Rat)
Gene Name
pyruvate dehydrogenase kinase, isozyme 1
Gene Symbol
Pdk1
Alternate Names
pyruvate dehydrogenase kinase, isozyme 1; PDK p48; PDH kinase 1; pyruvate dehydrogenase kinase 1; pyruvate dehydrogenase kinase, isoenzyme 1; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial;
Chromosome
3
Map Location
3q22
Summary
catalyzes the phosphorylation and inactivation of the pyruvate dehydrogenase complex [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pdk1

Proteins

pyruvate dehydrogenase kinase, isozyme 1 precursor
Refseq ID NP_446278
Protein GI 59709473
UniProt ID Q5FVT5
mRNA ID NM_053826
Length 434
MRLARLLRGGTSVRPLCAVPCASRSLASDSASGSGPASESGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKTIYEFTDTVIRIRNRHNDVIPTMAQGVTEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGSPSHRKHIGSINPNCDVVEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHADKGVYPPIQVHVTLGEEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTESIERLPVYNKAAWKHYRTNHEADDWCVPSREPKDMTTFRSS
transit_peptide: 1..26 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q63065.1) calculated_mol_wt: 2784 peptide sequence: MRLARLLRGGTSVRPLCAVPCASRSL

Gene Information

Entrez Gene ID
116551
Gene Name
pyruvate dehydrogenase kinase, isozyme 1
Gene Symbol
Pdk1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016301 IEA:UniProtKB-KW F kinase activity

KEGG Pathway Links

KEGG Pathway ID Description
rno04066 HIF-1 signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR005467 Signal transduction histidine kinase, core

UniProt Annotations

Entry Information

Gene Name
pyruvate dehydrogenase kinase, isozyme 1
Protein Entry
Q5FVT5_RAT
UniProt ID
Q5FVT5
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012872 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
59709473 RefSeq NP_446278 434 pyruvate dehydrogenase kinase, isozyme 1 precursor

Identical Sequences to LMP012872 proteins

Reference Database Accession Length Protein Name
GI:59709473 GenBank AAH89783.1 434 Pyruvate dehydrogenase kinase, isozyme 1 [Rattus norvegicus]

Related Sequences to LMP012872 proteins

Reference Database Accession Length Protein Name
GI:59709473 GenBank AAA62851.1 434 pyruvate dehydrogenase kinase kinase [Rattus norvegicus]
GI:59709473 GenBank AAH89783.1 434 Pyruvate dehydrogenase kinase, isozyme 1 [Rattus norvegicus]
GI:59709473 SwissProt Q63065.1 434 RecName: Full=[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; AltName: Full=PDK p48; AltName: Full=Pyruvate dehydrogenase kinase isoform 1; Short=PDH kinase 1; Flags: Precursor [Rattus norvegicus]