Gene/Proteome Database (LMPD)

LMPD ID
LMP012846
Gene ID
113956
Species
Rattus norvegicus (Rat)
Gene Name
peroxisomal trans-2-enoyl-CoA reductase
Gene Symbol
Pecr
Synonyms
TERP;
Alternate Names
peroxisomal trans-2-enoyl-CoA reductase; RLF98; PX-2,4-DCR1; perosisomal 2-enoyl-CoA reductase; peroxisomal 2,4-dienoyl-CoA reductase;
Chromosome
9
Map Location
9q33
EC Number
1.3.1.38
Summary
member of the short-chain dehydrogenase/reductase (SDR) family [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pecr

Proteins

peroxisomal trans-2-enoyl-CoA reductase
Refseq ID NP_579833
Protein GI 18959236
UniProt ID Q9WVK3
mRNA ID NM_133299
Length 303
MGSWKSGQSYLAAGLLQNQVAVVTGGATGIGKAISRELLHLGCNVVIASRKLDRLTAAVDELRASQPPSSSTQVTAIQCNIRKEEEVNNLVKSTLAKYGKINFLVNNAGGQFMAPAEDITAKGWQAVIETNLTGTFYMCKAVYNSWMKDHGGSIVNIIVLLNNGFPTAAHSGAARAGVYNLTKTMALTWASSGVRINCVAPGTIYSQTAVDNYGELGQTMFEMAFENIPAKRVGLPEEISPLVCFLLSPAASFITGQLINVDGGQALYTRNFTIPDHDNWPVGAGDSSFIKKVKESLKKQARL

Gene Information

Entrez Gene ID
113956
Gene Name
peroxisomal trans-2-enoyl-CoA reductase
Gene Symbol
Pecr
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043231 ISS:UniProtKB C intracellular membrane-bounded organelle
GO:0005739 ISS:UniProtKB C mitochondrion
GO:0005778 ISS:UniProtKB C peroxisomal membrane
GO:0005777 IDA:HGNC C peroxisome
GO:0019166 ISS:UniProtKB F trans-2-enoyl-CoA reductase (NADPH) activity
GO:0006633 IEA:UniProtKB-UniPathway P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko01040 Biosynthesis of unsaturated fatty acids
rno01040 Biosynthesis of unsaturated fatty acids
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
rno01100 Metabolic pathways
ko04146 Peroxisome
rno04146 Peroxisome

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
peroxisomal trans-2-enoyl-CoA reductase
Protein Entry
PECR_RAT
UniProt ID
Q9WVK3
Species
Rat

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
Function Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity (By similarity)
Induction Up-regulated by fasting
Pathway Lipid metabolism; fatty acid biosynthesis.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family
Subcellular Location Peroxisome .
Subunit Interacts with PEX5, probably required to target it into peroxisomes
Tissue Specificity Highly expressed in liver and kidney. Weakly expressed in other tissues

Identical and Related Proteins

Unique RefSeq proteins for LMP012846 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18959236 RefSeq NP_579833 303 peroxisomal trans-2-enoyl-CoA reductase

Identical Sequences to LMP012846 proteins

Reference Database Accession Length Protein Name
GI:18959236 GenBank ABH81983.1 303 Sequence 13 from patent US 7045325
GI:18959236 GenBank EDL75248.1 303 peroxisomal trans-2-enoyl-CoA reductase, isoform CRA_b [Rattus norvegicus]
GI:18959236 GenBank ACP59667.1 303 Sequence 13 from patent US 7494793
GI:18959236 SwissProt Q9WVK3.1 303 RecName: Full=Peroxisomal trans-2-enoyl-CoA reductase; Short=TERP; AltName: Full=PX-2,4-DCR1; AltName: Full=Peroxisomal 2,4-dienoyl-CoA reductase; AltName: Full=RLF98 [Rattus norvegicus]

Related Sequences to LMP012846 proteins

Reference Database Accession Length Protein Name
GI:18959236 GenBank AAO99156.1 303 Sequence 25 from patent US 6511834
GI:18959236 GenBank AAR55669.1 303 Sequence 13 from patent US 6613555
GI:18959236 GenBank AAR64126.1 303 Sequence 13 from patent US 6627423