LIPID MAPS

LMPD ID

LMP012845

Gene ID

113919

Species

Rattus norvegicus (Rat)

Gene Name

glutathione peroxidase 5

Gene Symbol

Gpx5

Alternate Names

epididymal secretory glutathione peroxidase; EGLP; GPx-5; GSHPx-5; epididymis-specific glutathione peroxidase-like protein;

Chromosome

17

Map Location

17q11

EC Number

1.11.1.9

Summary

enzyme that catalyzes the reduction of lipid peroxides; has a role in the hydrogen peroxide scavenging system found within the epididymis [RGD, Feb 2006]

Orthologs

View orthologs and multiple alignments for Gpx5

epididymal secretory glutathione peroxidase precursor
Refseq ID	NP_001099208
Protein GI	157786758
UniProt ID	P30710
mRNA ID	NM_001105738
Length	221
MAIQLRVFYLVPLLLASYVQTTPRLEKMKMDCYKDVKGTIYNYEALSLNGKERIPFKQYAGKHVLFVNVATYCGLTIQYPELNALQDDLKQFGLVILGFPCNQFGKQEPGDNTEILPGLKYVRPGKGFLPNFQLFAKGDVNGEKEQEIFTFLKRSCPHPSETVVTSKHTFWEPIKVHDIRWNFEKFLVGPNGVPVMRWFHQAPVSTVKSDILAYLNQFKTI
sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2439 peptide sequence: MAIQLRVFYLVPLLLASYVQT mat_peptide: 22..221 product: Epididymal secretory glutathione peroxidase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P30710.1) calculated_mol_wt: 22964 peptide sequence: TPRLEKMKMDCYKDVKGTIYNYEALSLNGKERIPFKQYAGKHVLFVNVATYCGLTIQYPELNALQDDLKQFGLVILGFPCNQFGKQEPGDNTEILPGLKYVRPGKGFLPNFQLFAKGDVNGEKEQEIFTFLKRSCPHPSETVVTSKHTFWEPIKVHDIRWNFEKFLVGPNGVPVMRWFHQAPVSTVKSDILAYLNQFKTI

Entrez Gene ID

113919

Gene Name

glutathione peroxidase 5

Gene Symbol

Gpx5

Species

Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005576	IEA:UniProtKB-KW	C	extracellular region
GO:0004602	IEA:UniProtKB-EC	F	glutathione peroxidase activity
GO:0006979	IEA:InterPro	P	response to oxidative stress

KEGG Pathway Links

KEGG Pathway ID	Description
ko00590	Arachidonic acid metabolism
rno00590	Arachidonic acid metabolism
ko00480	Glutathione metabolism
rno00480	Glutathione metabolism
ko04918	Thyroid hormone synthesis
rno04918	Thyroid hormone synthesis

InterPro Annotations

Accession	Description
IPR000889	Glutathione peroxidase
IPR029759	Glutathione peroxidase active site
IPR029760	Glutathione peroxidase conserved site
IPR012336	Thioredoxin-like fold

Entry Information

Gene Name

glutathione peroxidase 5

Protein Entry

GPX5_RAT

UniProt ID

P30710

Species

Rat

Comments

Comment Type	Description
Catalytic Activity	2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
Function	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
Similarity	Belongs to the glutathione peroxidase family
Subcellular Location	Secreted.
Tissue Specificity	Epididymis.

Unique RefSeq proteins for LMP012845 (as displayed in Record Overview)

Protein GI	Database	Accession	Length	Protein Name
157786758	RefSeq	NP_001099208	221	epididymal secretory glutathione peroxidase precursor

Identical Sequences to LMP012845 proteins

Reference	Database	Accession	Length	Protein Name
GI:157786758	EMBL	CAA44274.1	221	epididymal secretory glutathione peroxidase [Rattus rattus]
GI:157786758	GenBank	EDL84536.1	221	glutathione peroxidase 5 [Rattus norvegicus]
GI:157786758	SwissProt	P30710.1	221	RecName: Full=Epididymal secretory glutathione peroxidase; AltName: Full=Epididymis-specific glutathione peroxidase-like protein; Short=EGLP; AltName: Full=Glutathione peroxidase 5; Short=GPx-5; Short=GSHPx-5; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012845 proteins

Reference	Database	Accession	Length	Protein Name
GI:157786758	EMBL	CAA44274.1	221	epididymal secretory glutathione peroxidase [Rattus rattus]
GI:157786758	GenBank	EDL84536.1	221	glutathione peroxidase 5 [Rattus norvegicus]
GI:157786758	SwissProt	P30710.1	221	RecName: Full=Epididymal secretory glutathione peroxidase; AltName: Full=Epididymis-specific glutathione peroxidase-like protein; Short=EGLP; AltName: Full=Glutathione peroxidase 5; Short=GPx-5; Short=GSHPx-5; Flags: Precursor [Rattus norvegicus]