Gene/Proteome Database (LMPD)

LMPD ID
LMP012813
Gene ID
84431
Species
Rattus norvegicus (Rat)
Gene Name
N-acylsphingosine amidohydrolase (acid ceramidase) 1
Gene Symbol
Asah1
Synonyms
Asah;
Alternate Names
acid ceramidase; AC; ACDase; acid CDase; acylsphingosine deacylase; N-acylsphingosine amidohydrolase 1;
Chromosome
16
Map Location
16q12.1
EC Number
3.5.1.23

Proteins

acid ceramidase precursor
Refseq ID NP_445859
Protein GI 40254747
UniProt ID Q6P7S1
mRNA ID NM_053407
Length 394
MLGRSLLTWVLAAAVTCAQAQQVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKRWHELLAHKAPVLRTLVNSISNLVNAFVPSGKIMQMVDEKLPGLIGSIPGPFGEEMRGIADVTGIPLGEIISFNIFYELFTMCTSIITEDGKGHLLHGRNMDFGIFLGWNINNNTWVVTEELKPLTVNLDFQRNNKTVFKATSFAGYVGMLTGFKPGLLSLTLNERFSLNGGYLGILEWMFGKKNAQWVGFITRSVLENSTSYEEAKNILTKTKITAPAYFILGGNQSGEGCVITRERKESLDVYELDPKHGRWYVVQTNYDRWKNTLFLDDRRTPAKKCLNHTTQKNLSFATIYDVLSTKPVLNKLTVFTTLIDVTKDQFESHLRDCPDPCIGW
sig_peptide: 1..20 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2076 peptide sequence: MLGRSLLTWVLAAAVTCAQA mat_peptide: 21..394 product: Acid ceramidase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q6P7S1.1) calculated_mol_wt: 42386 peptide sequence: QQVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKRWHELLAHKAPVLRTLVNSISNLVNAFVPSGKIMQMVDEKLPGLIGSIPGPFGEEMRGIADVTGIPLGEIISFNIFYELFTMCTSIITEDGKGHLLHGRNMDFGIFLGWNINNNTWVVTEELKPLTVNLDFQRNNKTVFKATSFAGYVGMLTGFKPGLLSLTLNERFSLNGGYLGILEWMFGKKNAQWVGFITRSVLENSTSYEEAKNILTKTKITAPAYFILGGNQSGEGCVITRERKESLDVYELDPKHGRWYVVQTNYDRWKNTLFLDDRRTPAKKCLNHTTQKNLSFATIYDVLSTKPVLNKLTVFTTLIDVTKDQFESHLRDCPDPCIGW

Gene Information

Entrez Gene ID
84431
Gene Name
N-acylsphingosine amidohydrolase (acid ceramidase) 1
Gene Symbol
Asah1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005764 IEA:UniProtKB-KW C lysosome
GO:0017040 IEA:UniProtKB-EC F ceramidase activity
GO:0006629 IEA:InterPro P lipid metabolic process
GO:0030324 IDA:RGD P lung development
GO:0010033 IDA:RGD P response to organic substance

KEGG Pathway Links

KEGG Pathway ID Description
ko04142 Lysosome
rno04142 Lysosome
rno01100 Metabolic pathways
ko00600 Sphingolipid metabolism
rno00600 Sphingolipid metabolism
M00099 Sphingosine biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5954485 Glycosphingolipid metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954267 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029130 Acid ceramidase, N-terminal
IPR016699 Acid_ceramidase-like
IPR029132 Choloylglycine hydrolase/NAAA C-terminal

UniProt Annotations

Entry Information

Gene Name
N-acylsphingosine amidohydrolase (acid ceramidase) 1
Protein Entry
ASAH1_RAT
UniProt ID
Q6P7S1
Species
Rat

Comments

Comment Type Description
Catalytic Activity N-acylsphingosine + H(2)O = a carboxylate + sphingosine.
Function Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid
Similarity Belongs to the acid ceramidase family
Subcellular Location Lysosome .
Subunit Heterodimer of one alpha and one beta subunit

Identical and Related Proteins

Unique RefSeq proteins for LMP012813 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
40254747 RefSeq NP_445859 394 acid ceramidase precursor

Identical Sequences to LMP012813 proteins

Reference Database Accession Length Protein Name
GI:40254747 GenBank AAH61540.1 394 N-acylsphingosine amidohydrolase (acid ceramidase) 1 [Rattus norvegicus]
GI:40254747 SwissProt Q6P7S1.1 394 RecName: Full=Acid ceramidase; Short=AC; Short=ACDase; Short=Acid CDase; AltName: Full=Acylsphingosine deacylase; AltName: Full=N-acylsphingosine amidohydrolase; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012813 proteins

Reference Database Accession Length Protein Name
GI:40254747 GenBank AAG43956.1 394 ceramidase [Rattus norvegicus]
GI:40254747 GenBank AAH61540.1 394 N-acylsphingosine amidohydrolase (acid ceramidase) 1 [Rattus norvegicus]
GI:40254747 SwissProt Q6P7S1.1 394 RecName: Full=Acid ceramidase; Short=AC; Short=ACDase; Short=Acid CDase; AltName: Full=Acylsphingosine deacylase; AltName: Full=N-acylsphingosine amidohydrolase; Flags: Precursor [Rattus norvegicus]