Gene/Proteome Database (LMPD)

LMPD ID
LMP012783
Gene ID
83522
Species
Rattus norvegicus (Rat)
Gene Name
acyl-CoA oxidase 3, pristanoyl
Gene Symbol
Acox3
Alternate Names
peroxisomal acyl-coenzyme A oxidase 3; BRCACox; pristanoyl-CoA oxidase; branched-chain acyl-CoA oxidase; acyl-Coenzyme A oxidase 3, pristanoyl;
Chromosome
14
Map Location
14q21
EC Number
1.3.3.6
Summary
targeted to the peroxisome; hepatic expression is not altered in the presence of peroxisome proliferators [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Acox3

Proteins

peroxisomal acyl-coenzyme A oxidase 3
Refseq ID NP_445791
Protein GI 16758056
UniProt ID Q63448
mRNA ID NM_053339
Length 700
MGSSSERRDSVLWSDIPKGPLSAYRARASFNSKELMLFWDGQDVLDFKKTIFSTLENDPLFARPFGADLPLEKERELNFLRCKRVFEYGFFNAEDMLKNPLKILVLMNCLGMYDWSLANKCVLHMLVFGSTIIGSGSEHHFKYLEKIYNLEIFGCFALTELSHGSNTKAMRTTAHYDPATQEFILHSPDFEAAKFWVGNLGKTATHAVVFAQLYTPDGQCRGLHSFLVQIRDPKTLLPMPGVMVGDMGKKLGQNGLDNGFAMFHKVRIPRQNLLDRTGNVTSEGHYHTPFKDVRQRLGASLGSLSSGRISIISISVVNLKLAVIIAIRFSATRRQFGPTDKEEIPVLEYPLQQWRLLPYLAAAYALDHFSKTIFLDLIELQRAGKVGTTVTGRQSSGREIHALASAGKPLASWTAQRGIQECREVVGGHGYLAMNRFGELRNDNDPNCTYEGDNNVLLQQTSNYLLSLLEHPLQDGAHFTSPLKTVNFLEAYPGILGQKFMASSKADWLDSEAPLAAYRWLVCYLLRESHQRYCQEKKSRGSDFEARNNSQVYGCRPLALAFMELTVMQRFHEHTHSSSVPPSLRTVLGRLSMLYGLWCLSQHTALLYRGGYISGEQTGKAMEDAILMLCVQLKDDAVALVDAIAPSDFVLGSPIGRADGELYKNLWAAVLQQSGVLERAAWWPEFTANKSVANRLKSQL

Gene Information

Entrez Gene ID
83522
Gene Name
acyl-CoA oxidase 3, pristanoyl
Gene Symbol
Acox3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005777 IDA:HGNC C peroxisome
GO:0003995 IEA:InterPro F acyl-CoA dehydrogenase activity
GO:0005504 IDA:RGD F fatty acid binding
GO:0050660 IDA:RGD F flavin adenine dinucleotide binding
GO:0016402 IDA:RGD F pristanoyl-CoA oxidase activity
GO:0033540 IDA:RGD P fatty acid beta-oxidation using acyl-CoA oxidase

KEGG Pathway Links

KEGG Pathway ID Description
ko01040 Biosynthesis of unsaturated fatty acids
rno01040 Biosynthesis of unsaturated fatty acids
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
rno01100 Metabolic pathways
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway
ko04146 Peroxisome
rno04146 Peroxisome
ko00592 alpha-Linolenic acid metabolism
rno00592 alpha-Linolenic acid metabolism
M00087 beta-Oxidation
ko04024 cAMP signaling pathway
rno04024 cAMP signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR012258 Acyl-CoA oxidase
IPR002655 Acyl-CoA oxidase, C-terminal
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain

UniProt Annotations

Entry Information

Gene Name
acyl-CoA oxidase 3, pristanoyl
Protein Entry
ACOX3_RAT
UniProt ID
Q63448
Species
Rat

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2).
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692;
Function Oxidizes the CoA-esters of 2-methyl-branched fatty acids
Pathway Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Similarity Belongs to the acyl-CoA oxidase family
Subcellular Location Peroxisome.
Tissue Specificity Most abundant in liver, kidney, lung, and testis. Present in all tissues tested.

Identical and Related Proteins

Unique RefSeq proteins for LMP012783 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16758056 RefSeq NP_445791 700 peroxisomal acyl-coenzyme A oxidase 3

Identical Sequences to LMP012783 proteins

Reference Database Accession Length Protein Name
GI:16758056 EMBL CBU96034.1 700 unnamed protein product [Rattus norvegicus]
GI:16758056 GenBank AGX52711.1 700 Sequence 5777 from patent US 8541208
GI:16758056 GenBank AGX57648.1 700 Sequence 15639 from patent US 8541208
GI:16758056 GenBank AGX63432.1 700 Sequence 26968 from patent US 8541208

Related Sequences to LMP012783 proteins

Reference Database Accession Length Protein Name
GI:16758056 EMBL CBU85837.1 700 unnamed protein product [Rattus norvegicus]
GI:16758056 EMBL CBU90618.1 700 unnamed protein product [Rattus norvegicus]
GI:16758056 EMBL CBU96034.1 700 unnamed protein product [Rattus norvegicus]