Gene/Proteome Database (LMPD)

LMPD ID
LMP012777
Gene ID
81925
Species
Rattus norvegicus (Rat)
Gene Name
CDP-diacylglycerol synthase 1
Gene Symbol
Cds1
Alternate Names
phosphatidate cytidylyltransferase 1; CDS 1; CDP-DG synthase 1; CDP-DAG synthase 1; CDP-DG synthetase 1; CDP-diglyceride synthase 1; CDP-diglyceride synthetase 1; CDP-diglyceride pyrophosphorylase 1; CTP:phosphatidate cytidylyltransferase 1; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1;
Chromosome
14
Map Location
14p22
EC Number
2.7.7.41
Summary
human homolog catalyzes the conversion of phosphatidic acid to CDP-diacylglycerol [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Cds1

Proteins

phosphatidate cytidylyltransferase 1
Refseq ID NP_112521
Protein GI 148747375
UniProt ID O35052
mRNA ID NM_031242
Length 461
MLELRHRGGCPGPGGAGTPPPREGEAAGGDHETESTSDKETDIDDRYGDLDARGDSDVPEVPPSSDRTPEILKKALSGLSSRWKNWWIRGILTLTMISLFFLIIYMGSFMLMLLVLGIQVKCFQEIITIGYRVYHSYDLPWFRTLSWYFLLCVNYFFYGETVADYFATFVQREEQLQFLIRYHRFISFALYLAGFCMFVLSLVKKHYRLQFYMFAWTHVTLLITVTQSHLVIQNLFEGMIWFLVPISSVICNDITAYLFGFFFGRTPLIKLSPKKTWEGFIGGFFSTVIFGFIAAYVLSKYQYFVCPVEYRSDVNSFVTECEPSELFQLQNYSLPPFLQAVLSRETVSLYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVHVYITSFIRGPNPSKVLQQLLVLQPEQQLNIYRTLKIHLTEKGILQPTWKV

Gene Information

Entrez Gene ID
81925
Gene Name
CDP-diacylglycerol synthase 1
Gene Symbol
Cds1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IDA:RGD C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004605 IDA:RGD F phosphatidate cytidylyltransferase activity
GO:0016024 ISS:UniProtKB P CDP-diacylglycerol biosynthetic process
GO:0006661 ISS:UniProtKB P phosphatidylinositol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5954475 Synthesis of PI

Domain Information

InterPro Annotations

Accession Description
IPR000374 Phosphatidate cytidylyltransferase
IPR016720 Phosphatidate cytidylyltransferase, eukaryota

UniProt Annotations

Entry Information

Gene Name
CDP-diacylglycerol synthase 1
Protein Entry
CDS1_RAT
UniProt ID
O35052
Species
Rat

Comments

Comment Type Description
Catalytic Activity CTP + phosphatidate = diphosphate + CDP- diacylglycerol.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Function Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells (By similarity). May play an important role in phosphoinositide synthesis, prefers 1-stearoyl-2-arachidonoyl phosphatidic acid as substrate
Induction Activated by GTP. Inhibited by CDP-diacylglycerol (product inhibition).
Pathway Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Similarity Belongs to the CDS family
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein . Note=Cytoplasmic aspect of the endoplasmic reticulum.
Subunit Interacts with FOS; this interaction may enhance catalytic activity
Tissue Specificity Brain, retina and testis. Found in cerebellar Purkinje cells, pineal body, inner segment of photoreceptor cells and postmitotic spermatocytes and spermatids.

Identical and Related Proteins

Unique RefSeq proteins for LMP012777 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
148747375 RefSeq NP_112521 461 phosphatidate cytidylyltransferase 1

Identical Sequences to LMP012777 proteins

Reference Database Accession Length Protein Name
GI:148747375 GenBank AAI27493.1 461 CDP-diacylglycerol synthase 1 [Rattus norvegicus]
GI:148747375 GenBank EDL99537.1 461 CDP-diacylglycerol synthase 1 [Rattus norvegicus]
GI:148747375 SwissProt O35052.2 461 RecName: Full=Phosphatidate cytidylyltransferase 1; AltName: Full=CDP-DAG synthase 1; AltName: Full=CDP-DG synthase 1; AltName: Full=CDP-diacylglycerol synthase 1; Short=CDS 1; AltName: Full=CDP-diglyceride pyrophosphorylase 1; AltName: Full=CDP-diglyceride synthase 1; AltName: Full=CTP:phosphatidate cytidylyltransferase 1 [Rattus norvegicus]

Related Sequences to LMP012777 proteins

Reference Database Accession Length Protein Name
GI:148747375 GenBank AAI27493.1 461 CDP-diacylglycerol synthase 1 [Rattus norvegicus]
GI:148747375 GenBank EDL99537.1 461 CDP-diacylglycerol synthase 1 [Rattus norvegicus]
GI:148747375 SwissProt O35052.2 461 RecName: Full=Phosphatidate cytidylyltransferase 1; AltName: Full=CDP-DAG synthase 1; AltName: Full=CDP-DG synthase 1; AltName: Full=CDP-diacylglycerol synthase 1; Short=CDS 1; AltName: Full=CDP-diglyceride pyrophosphorylase 1; AltName: Full=CDP-diglyceride synthase 1; AltName: Full=CTP:phosphatidate cytidylyltransferase 1 [Rattus norvegicus]