Gene/Proteome Database (LMPD)

LMPD ID
LMP012774
Gene ID
81821
Species
Rattus norvegicus (Rat)
Gene Name
diacylglycerol kinase zeta
Gene Symbol
Dgkz
Alternate Names
diacylglycerol kinase zeta; DGK-IV; DGK-zeta; DAG kinase zeta; diglyceride kinase zeta; 104 kDa diacylglycerol kinase;
Chromosome
3
Map Location
3q24
EC Number
2.7.1.107
Summary
catalyzes the conversion of diacylglycerol to phosphatidic acid [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Dgkz

Proteins

diacylglycerol kinase zeta
Refseq ID NP_112405
Protein GI 13592131
UniProt ID O08560
mRNA ID NM_031143
Length 929
MEPRDPSPEARSSDSESASASSSGSERDADPEPDKAPRRLTKRRFPGLRLFGHRKAITKSGLQHLAPPPPTPGAPCGESERQIRSTVDWSESAAYGEHIWFETNVSGDFCYVGEQYCVAKMLPKSAPRRKCAACKIVVHTPCIGQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRRSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPREALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLRAEPNPEAGPEERDDGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCIVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVLLTTAKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSTAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPMCHPLSSKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPASPCSPTPGSLQGDAALPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDHQSRTLLHHAVSTGSKEVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV

Gene Information

Entrez Gene ID
81821
Gene Name
diacylglycerol kinase zeta
Gene Symbol
Dgkz
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0030027 IEA:Ensembl C lamellipodium
GO:0005634 IDA:RGD C nucleus
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0004143 IDA:RGD F diacylglycerol kinase activity
GO:0004857 IEA:Ensembl F enzyme inhibitor activity
GO:0001727 IEA:Ensembl F lipid kinase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0031571 IEA:Ensembl P mitotic G1 DNA damage checkpoint
GO:0046580 IEA:Ensembl P negative regulation of Ras protein signal transduction
GO:0045930 IEA:Ensembl P negative regulation of mitotic cell cycle
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5953655 Effects of PIP2 hydrolysis
5953653 G alpha (q) signalling events
5953642 GPCR downstream signaling
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5953645 Hemostasis
5953644 Platelet activation, signaling and aggregation
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol kinase zeta
Protein Entry
DGKZ_RAT
UniProt ID
O08560
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Function Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Regulates RASGRP1 activity (By similarity)
Interaction Q62696:Dlg1; NbExp=4; IntAct=EBI-8570505, EBI-389325; Q63622:Dlg2; NbExp=4; IntAct=EBI-8570505, EBI-396947; Q62936:Dlg3; NbExp=4; IntAct=EBI-8570505, EBI-349596; P31016:Dlg4; NbExp=6; IntAct=EBI-8570505, EBI-375655;
Similarity Belongs to the eukaryotic diacylglycerol kinase family
Similarity Contains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Similarity Contains 2 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Similarity Contains 2 phorbol-ester/DAG-type zinc fingers
Subcellular Location Cytoplasm . Nucleus {ECO:0000269|PubMed:8855332}. Cell membrane .
Subunit Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Forms a signaling complex with RASGRP1 and HRAS (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012774 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13592131 RefSeq NP_112405 929 diacylglycerol kinase zeta

Identical Sequences to LMP012774 proteins

Reference Database Accession Length Protein Name
GI:13592131 DBBJ BAA18942.1 929 diacylglycerol kinase [Rattus norvegicus]
GI:13592131 GenBank EDL79551.1 929 diacylglycerol kinase zeta, isoform CRA_a [Rattus norvegicus]
GI:13592131 GenBank EDL79552.1 929 diacylglycerol kinase zeta, isoform CRA_a [Rattus norvegicus]
GI:13592131 SwissProt O08560.1 929 RecName: Full=Diacylglycerol kinase zeta; Short=DAG kinase zeta; AltName: Full=104 kDa diacylglycerol kinase; AltName: Full=DGK-IV; AltName: Full=Diglyceride kinase zeta; Short=DGK-zeta [Rattus norvegicus]

Related Sequences to LMP012774 proteins

Reference Database Accession Length Protein Name
GI:13592131 DBBJ BAA18942.1 929 diacylglycerol kinase [Rattus norvegicus]
GI:13592131 GenBank EDL79551.1 929 diacylglycerol kinase zeta, isoform CRA_a [Rattus norvegicus]
GI:13592131 SwissProt O08560.1 929 RecName: Full=Diacylglycerol kinase zeta; Short=DAG kinase zeta; AltName: Full=104 kDa diacylglycerol kinase; AltName: Full=DGK-IV; AltName: Full=Diglyceride kinase zeta; Short=DGK-zeta [Rattus norvegicus]