Gene/Proteome Database (LMPD)

LMPD ID
LMP012773
Gene ID
81782
Species
Rattus norvegicus (Rat)
Gene Name
sterol O-acyltransferase 1
Gene Symbol
Soat1
Synonyms
Acat-1;
Alternate Names
sterol O-acyltransferase 1; cholesterol acyltransferase 1; acyl coenzyme A:cholesterol acyltransferase 1; acyl-coenzyme A:cholesterol acyltransferase 1;
Chromosome
13
Map Location
13q21
EC Number
2.3.1.26
Summary
catalyzes the conversion of free cholesterol and fatty acyl-CoA to cholesteryl esters; plays a role in cholesterol metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Soat1

Proteins

sterol O-acyltransferase 1
Refseq ID NP_112380
Protein GI 13592087
UniProt ID O70536
mRNA ID NM_031118
Length 545
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF

Gene Information

Entrez Gene ID
81782
Gene Name
sterol O-acyltransferase 1
Gene Symbol
Soat1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0034736 IEA:UniProtKB-EC F cholesterol O-acyltransferase activity
GO:0004772 IDA:RGD F sterol O-acyltransferase activity
GO:0008203 TAS:RGD P cholesterol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00100 Steroid biosynthesis
rno00100 Steroid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR004299 Membrane bound O-acyl transferase, MBOAT
IPR014371 Sterol O-acyltransferase, ACAT/DAG/ARE types

UniProt Annotations

Entry Information

Gene Name
sterol O-acyltransferase 1
Protein Entry
SOAT1_RAT
UniProt ID
O70536
Species
Rat

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + cholesterol = CoA + cholesterol ester.
Function Catalyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption.
Similarity Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Subunit May form homo- or heterodimers. Interacts with UBIAD1 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012773 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13592087 RefSeq NP_112380 545 sterol O-acyltransferase 1

Identical Sequences to LMP012773 proteins

Reference Database Accession Length Protein Name
GI:13592087 DBBJ BAA25372.1 545 acyl-coenzyme A:cholesterol acyltransferase [Rattus norvegicus]
GI:13592087 SwissProt O70536.1 545 RecName: Full=Sterol O-acyltransferase 1; AltName: Full=Acyl-coenzyme A:cholesterol acyltransferase 1; Short=ACAT-1; AltName: Full=Cholesterol acyltransferase 1 [Rattus norvegicus]

Related Sequences to LMP012773 proteins

Reference Database Accession Length Protein Name
GI:13592087 DBBJ BAA25372.1 545 acyl-coenzyme A:cholesterol acyltransferase [Rattus norvegicus]
GI:13592087 GenBank EDM09484.1 545 sterol O-acyltransferase 1, isoform CRA_a [Rattus norvegicus]
GI:13592087 SwissProt O70536.1 545 RecName: Full=Sterol O-acyltransferase 1; AltName: Full=Acyl-coenzyme A:cholesterol acyltransferase 1; Short=ACAT-1; AltName: Full=Cholesterol acyltransferase 1 [Rattus norvegicus]